Electrocardiographic safety evaluation of dihydroartemisinin piperaquine in the treatment of uncomplicated falciparum malaria.

Dihydroartemisinin-piperaquine (DP) could become a leading fixed combination malaria treatment worldwide. Although there is accumulating evidence of efficacy and safety from clinical trials, data on cardiotoxicity are limited. In two randomized controlled trials in Thailand, 56 patients had ECGs performed before treatment, 4 hours after the first dose, and 4 hours after the last dose. The mean (95% CI) changes in QTc interval (Bazett's correction) were 2 (-6 to 9) ms and 14 (7 to 21) ms, respectively. These small changes on the third day of treatment are similar to those observed elsewhere in the convalescent phase following antimalarial treatment with drugs known to have no cardiac effects and are therefore likely to result from recovery from acute malaria and not the treatment given. At therapeutic doses, DP does not have clinically significant effects on the electrocardiogram

Construction of the Soudan 2 detector

Progress in the construction of the Soudan 2 nucleon decay detector which is being built at the Soudan iron mine in Minnesota is discussed. The expected event rate and characteristics of low energy neutrino events, muon events, multiple muon events, and other cosmic ray phenomena are discussed

A shallow water ferrous-hulled shipwreck reveals a distinct microbial community.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).Shipwrecks act as artificial reefs and provide a solid surface in aquatic systems for many different forms of life to attach to, especially microbial communities, making them a hotspot of biogeochemical cycling. Depending on the microbial community and surrounding environment, they may either contribute to the wreck’s preservation or deterioration. Even within a single wreck, preservation and deterioration processes may vary, suggesting that the microbial community may also vary. This study aimed to identify the differences through widespread sampling of the microbial communities associated with the Pappy Lane shipwreck (NC shipwreck site #PAS0001), a shallow water ferrous-hulled shipwreck in Pamlico Sound, North Carolina to determine if there are differences across the wreck as well as from its surrounding environment. Loose shipwreck debris, drilled shipcores, surrounding sediment, and seawater samples were collected from the Pappy Lane shipwreck to characterize the microbial communities on and around the shipwreck. Results indicated that the shipwreck samples were more similar to each other than the surrounding sediment and aquatic environments suggesting they have made a specialized niche associated with the shipwreck. There were differences between the microbial community across the shipwreck, including between visibly corroded and non-corroded shipwreck debris pieces. Relative abundance estimates for neutrophilic iron-oxidizing bacteria (FeOB), an organism that may contribute to deterioration through biocorrosion, revealed they are present across the shipwreck and at highest abundance on the samples containing visible corrosion products. Zetaproteobacteria, a known class of marine iron-oxidizers, were also found in higher abundance on shipwreck samples with visible corrosion. A novel Zetaproteobacteria strain, Mariprofundus ferrooxydans O1, was isolated from one of the shipwreck pieces and its genome analyzed to elucidate the functional potential of the organism. In addition to iron oxidation pathways, the isolate has the genomic potential to perform carbon fixation in both high and low oxygen environments, as well as perform nitrogen fixation, contributing to the overall biogeochemical cycling of nutrients and metals in the shipwreck ecosystem. By understanding the microbial communities associated with shallow water ferrous-hulled shipwrecks, better management strategies and preservation plans can be put into place to preserve these artificial reefs and non-renewable cultural resources.ECU Open Access Publishing Support Fun

The distribution of iodine and bromine in the sediments of the southwestern Barents Sea

In 42 surface sediments from the southwestern Barents Sea, iodine and bromine ranged from 60 to 828 p.p.m. and 12 to 257 p.p.m., respectively. In the surface environment, both I and Br are related to organic matter; the dependence of halogens on the grain size of the sediment is small...

Beyond the multidisciplinary in fan studies: Learning how to talk among disciplines

In light of the Fan Studies Network's statement regarding fan studies being overrun with whiteness, we are in a unique position to engage in scholarship that challenges the overwhelmingly white and Global North–centric structures that define how we study fan cultures. Multidisciplinarity, which may be understood as disciplines laid side by side, should be contrasted with interdisciplinarity, which requires true dialogue. Despite recent field-shifting work by fan studies scholars such as Bertha Chin, Lori Morimoto, Rukmini Pande, and Rebecca Wanzo, more work needs to be done to both acknowledge and build on current research in transcultural fandom. In a dialogue that reflects the progress of our own striving toward interdisciplinary and transcultural work in fan studies, we seek to demonstrate a possible way forward for the field of fan studies to become more truly interdisciplinary and transcultural in its focus

The projected effect on insects, vertebrates, and plants of limiting global warming to 1.5°C rather than 2°C

In the Paris Agreement on Climate Change, the United Nations is pursuing efforts to limit global warming to 1.5°C, whereas earlier aspirations focused on a 2°C limit. With current pledges, corresponding to ~3.2°C warming, climatically determined geographic range losses of >50% are projected in ~49% of insects, 44% of plants, and 26% of vertebrates. At 2°C, this falls to 18% of insects, 16% of plants, and 8% of vertebrates and at 1.5°C, to 6% of insects, 8% of plants, and 4% of vertebrates. When warming is limited to 1.5°C as compared with 2°C, numbers of species projected to lose >50% of their range are reduced by ~66% in insects and by ~50% in plants and vertebrates