34 research outputs found
Experimental and theoretical studies of (4 + 1) annulations between αâoxoketenes and stable phosphorous, nitrogen, or sulfur ylides
Gallium(III)- and calcium(II)-catalyzed Meyer-Schuster rearrangements followed by intramolecular aldol condensation or endo-Michael addition
International audienc
Synthesis and indole coupling reactions of azetidine and oxetane sulfinate salts
Azetidine and oxetane sulfinate salts are easily prepared from commercially available 3-iodoheterocycle precursors in a three-step sequence. They undergo smooth coupling reactions thereby providing an expedient route for the introduction of these four-membered heterocycles into indoles
A new biological contribution of cyclo(His-Pro) to the peripheral inhibition of pancreatic secretion
Periselectivity Switch of Acylketenes in Cycloadditions with 1-Azadienes: Microwave-Assisted Diastereoselective Domino Three-Component Synthesis of α-Spiro-Ύ-lactams
Late-stage fluorination of bridged scaffolds: Chemoselective generation of a CHF group at three positions of the bicyclo[3.3.1]nonane system
Metal-free coupling of saturated heterocyclic sulfonylhydrazones with boronic acids
The coupling of aromatic moieties with saturated
heterocyclic partners is currently an area of significant interest for the pharmaceutical industry. Herein, we present a procedure for the metal-free coupling of 4-, 5-, and 6-membered saturated heterocyclic p-methoxyphenyl (PMP) sulfonylhydrazones with aryl and heteroaromatic boronic acids. This procedure enables a simple, two-step
synthesis of a range of functionalized sp2âsp3 linked bicyclic building blocks, including oxetanes, piperidines, and azetidines, from their parent ketones.
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