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Integrated Thematic Instruction : A Descriptive Case Study of its Adaptation and Implementation

The purpose of the study was to describe the operational form of the innovation--Integrated Thematic Instruction within the context of its implementation. An embedded single case study design was used to carry out this qualitative study, with Integrated Thematic Instruction (ITI) as the unit of the case study. The questions that guided the study were: What does ITI look like when implemented by the teacher? What are the contextual elements of implementation of this program? What variations are found in the implementation of this innovation by different teachers? A review of related literature revealed the historical, philosophical, and theoretical underpinnings of ITI. Several innovative educational practices were compared with ITI and parallels were drawn between them and ITI. Since this was the first descriptive research study of ITI, an Innovation Configuration of the program was developed. Interviews of the program developer, local program coordinators, as well as users (teachers), and observation of classroom implementation of ITI, helped in delineating its critical components; the ideal, acceptable, and unacceptable variations of its components were identified. The implementation context of ITI and the variations in teacher use of the components of the program were also studied. The case study was conducted at two different schools using ITI. The description of its context included school demography, the support systems, students, and selected psychological characteristics of the teachers.Implementation of the program is described first in general, and then in detail, focusing on its use by two teachers at each school. A brief analysis was made of the use of ITI at the two different sites. Several implications derived out of the study; these include those for further research, for staff developers and change facilitators, for principals, and for teachers using or intending to use ITI

D A -Homothetic Deformation of K-Contact Manifolds

We study Da-homothetic deformations of K-contact manifolds. We prove that Da-homothetically deformed K-contact manifold is a generalized Sasakian space form if it is conharmonically flat. Further, we find expressions for scalar curvature of Da-homothetically deformed K-contact manifolds

Recurrent generalized (κ,μ) space forms.

In this paper we study generalized (k, µ) space forms by considering certain curvature conditions like generalized recurrent, ricci recurrent, generalized φ recurrent conditions. We found relations among associated functions f1, f2, f3, f4, f5, f6 in φ-concorcular recurrent, quasi-conformally φ-flat and quasiconformally flat generalized (k, µ) space forms

Fibrocalculous pancreatic diabetes

This article does not have an abstract

Functional regulation of Sirt2 during oligodendrocyte development and its requirement during myelination and in an EAE mouse model of multiple sclerosis

In the central nervous system (CNS), oligodendroglial cells (OLs) form the myelin that ensheaths axons to ensure fast, efficient neurotransmission. Multiple sclerosis (MS) is a chronic demyelinating disease where myelin and myelinating OLs are damaged, making the axons more susceptible to degeneration. The cellular and molecular mechanisms that control the myelinating ability of OLs are largely unknown. The RNA binding protein quaking (QKI) regulates the expression of several myelin specific genes. Sirtuin 2 (SIRT2) is a NAD+ dependent deacetylase predominantly expressed in OLs. Both qkI and Sirt2 are upregulated during the period of intense CNS myelination in vivo; however, it is not known whether these two genes interact to regulate OL differentiation. In the first study, I tested the hypothesis that QKI interacts with Sirt2 mRNA to promote the expression of SIRT2 in OLs during development. I report for the first time that QKI directly interacts with Sirt2 mRNA at the 3' untranslated region, protects Sirt2 mRNA from degradation, and promotes SIRT2 expression in OL lineage cells. Considering the importance of Sirt2 in OL differentiation in vitro, I hypothesized that loss of Sirt2 would result in hypomyelination and increase the disease severity in an experimental autoimmune encephalomyelitis (EAE) mouse model of MS. My findings demonstrate that the loss of Sirt2 results in reduced expression of key myelin genes and a significant reduction in the number of myelinated axons in the CNS in vivo. In addition, Sirt2-/- mice displayed defects in OL precursor cells (OPC) proliferation and OL differentiation. EAE induction demonstrated that absence of Sirt2 results in an increased severity of EAE in Sirt2-/- mice compared to wild-type mice. These results suggest that Sirt2 plays a crucial role in OL development and myelination and a protective role in the EAE mouse model of MS. Finally, I investigated the targets through which Sirt2 could possibly regulate myelination. Cholesterol is crucial for myelin biogenesis. In neurons, SIRT2 has been implicated in cholesterol biosynthesis by promoting the nuclear translocation of SREBP-2. In this study, I hypothesized that SIRT2 positively regulates the translocation of SREBP-2 into the nucleus in OLs to promote cholesterol biosynthesis. My findings reveal that SREBP-2 and the downstream sterol biosynthesis pathway is not regulated by SIRT2 in OLs during CNS myelination. Collectively, these findings suggest that QKI regulates the expression of Sirt2, which plays a critical role in oligodendrogenesis and myelination of axons in the CNS through SREBP-2/cholesterol-independent mechanism. In addition, Sirt2 plays a protective role in the EAE mouse model. I believe this research will advance our knowledge in identifying target molecules that regulate the myelinating ability of OLs, leading to the development of potential nutrient and pharmacological therapies for MS

Water quality management in gold fish (Carassius auratus) rearing tanks using different filter materials

The present study deals with the management of water quality in Carassius auratus (gold fish) rearing tanks using different filter materials. The system with dead coral pieces (DCP) is the most suitable for rearing gold fish

Some biological aspects of two species of Barracudas from the South West coast of India

Two species of barracudas viz. Sphyraena obt usa ta and S. je/lo are commonl y caught fr?m the coastal waters of the southwest coast of India. The fishing season extends from October to May WIth two peaks; one in November and the otherinMarch which is closely associated with the breeding habits. Theiriength- weight studies showed differential growth in male and female. Analysis of stomach contents indicated that they are highly predatory fishes feeding mainly on other pelagic species. The barracudas have an extended spawning period with high fecundity rate