The Role of Place in Malcolm Cowley\u27s Blue Juniata and Exile\u27s Return

This study examines the various ways in which Malcolm Cowley develops and uses sense of place in his works Blue Juniata: Collected Poems and Exile\u27s Return. Through examination of the literature, I identify four phases of place sense. Starting with childhood in the Identification phase, I illustrate the development of Cowley\u27s place perspective through his poems and writings. As he moves through Adventure and Exile phases, I discuss their relation to the Identification phase and to each other. Likewise, I consider the role of the Nostalgia phase as a bridge from literary to experiential perception. Through close examination of his writing, I define the identifying features of each phase as well as their relationship to other phases. Further, I examine Cowley\u27s use of phases of place perception. One use is generational identification, allowing Cowley to differentiate his literary generation from those coming both before and after. Similar to this idea is the use of place perception to identify a certain time period. By linking place and ideology, Cowley metonymically references a certain set of experiences. The role of place perception as a metonymic identifier is drawn from the idea that place perception serves as a guide to background knowledge for the reader. An important aspect of its use as a guide is the establishment of common experience between Cowley and his audience. Finally, I explain the use of place perception as a mechanism for developing story. While I include Cowley\u27s own ideas concerning generations and the cycle of Adventure and Exile, the main assertion of my investigation is that he presents four distinct phases of place perception. Also, this study presents various ways in which Cowley uses place perception as an organizing theme in his works. Further, while he describes many of his experiences as attempts to disassociate from place, place perception is, paradoxically, at all times central to his thinking. Cowley uses various aspects of place and place perception in such a way that his own ideas of identity are inextricably tied to it. Ultimately, his life, as presented through his literature, illustrates the passage from naive childhood to nostalgic reflection

X band Class-E amplifier design

Abstract only availableThe goal of this research is to design and implement an X band Class-E amplifier. This amplifier will be centered on an ideal switch but, specific characteristics of the chosen transistor will be taken into account. The steps taken that compose the design of this amplifier are as follows. The first step is to use standard equations, which describe the behavior of ideal Class-E amplifies, to solve for lumped element circuit parameters. Once ideal parameters have been found the next step is to simulate the ideal model adding in non-ideal transistor parameters and tuning circuit parameters to compensate for the non-ideal transistor. The lumped element circuit will then undergo a necessary impedance transformation stage to match the output of the amplifier to a standard 50 ohm load. The final step in this design process is to transform the lumped element circuit into a micro-strip equivalent circuit. After the design has been completed microwave simulation software will be used to verify the operation of the micro-strip circuit.College of Engineering Undergraduate Research Optio

Female and male Leach\u27s Storm Petrels (Hydrobates leucorhous) pursue different foraging strategies during the incubation period

Reproduction in procellariiform birds is characterized by a single egg clutch, slow development, a long breeding season and obligate biparental care. Female Leach\u27s Storm Petrels Hydrobates leucorhous, nearly monomorphic members of this order, produce eggs that are between 20 and 25% of adult bodyweight. We tested whether female foraging behaviour differs from male foraging behaviour during the ~ 44-day incubation period across seven breeding colonies in the Northwest Atlantic. Over six breeding seasons, we used a combination of Global Positioning System and Global Location Sensor devices to measure characteristics of individual foraging trips during the incubation period. Females travelled significantly greater distances and went farther from the breeding colony than did males on individual foraging trips. For both sexes, the longer the foraging trip, the greater the distance. Independent of trip duration, females travelled farther, and spent a greater proportion of their foraging trips prospecting widely, as defined by behavioural categories derived from a hidden Markov Model. For both sexes, trip duration decreased with date. Sex differences in these foraging metrics were apparently not a consequence of morphological differences or spatial segregation. Our data are consistent with the idea that female foraging strategies differed from male foraging strategies during incubation in ways that would be expected if females were still compensating for egg formation

The Vehicle, Spring 2001

Vol. 42, No. 2 Table of Contents To Dream Without CeasingElizabeth Dedmanpage 4-5 Honoring Commandos at Spean BridgeKat Stevenspage 6 The Girl I NamelyKevin Manuspage 7 AbsolutionMike Mauritzenpage 8 Summertime SuperheroesChris Ptasnikpage 9 Flower at GlencoeKat Stevenspage 10 AddictionAdam Funkpage 11 Cornfield in JanuaryRobert Prattepage 12 MelancholyOona Margaret Burkepage 13 In PicturesAmanda McKaypage 14 Words to a Silent FilmBrianne Bolinpage 15 ManagerRobert Prattepage 16 The WellJanet Windegathpage 17 A Meal at the Personal Growth CafeAshley Kieferpage 18 Castlegate Evening at AberdeenKat Stevenspage 19 What We AreKevin Manuspage 20 Ode to My Gin-Soaked OlivesBrianne Bolinpage 21 The Six String PlayerRyan Guimondpage 22 MaxineJay Edwardspage 23 BarefootKrista Bodenpage 24 JulyAdam Funkpage 25 HopeOona Margaret Burkepage 26 UntitledLevy Wooln Dannerpage 27 The One and Only Picture I Have of YouKevin Manuspage 28 Death of a Fat ManBrianne Bolinpage 29-32https://thekeep.eiu.edu/vehicle/1075/thumbnail.jp

Doppler identified venous congestion in septic shock:protocol for an international, multi-centre prospective cohort study (Andromeda-VEXUS)

INTRODUCTION: Venous congestion is a pathophysiological state where high venous pressures cause organ oedema and dysfunction. Venous congestion is associated with worse outcomes, particularly acute kidney injury (AKI), for critically ill patients. Venous congestion can be measured by Doppler ultrasound at the bedside through interrogation of the inferior vena cava (IVC), hepatic vein (HV), portal vein (PV) and intrarenal veins (IRV). The objective of this study is to quantify the association between Doppler identified venous congestion and the need for renal replacement therapy (RRT) or death for patients with septic shock. METHODS AND ANALYSIS: This study is a prespecified substudy of the ANDROMEDA-SHOCK 2 (AS-2) randomised control trial (RCT) assessing haemodynamic resuscitation in septic shock and will enrol at least 350 patients across multiple sites. We will include adult patients within 4 hours of fulfilling septic shock definition according to Sepsis-3 consensus conference. Using Doppler ultrasound, physicians will interrogate the IVC, HV, PV and IRV 6-12 hours after randomisation. Study investigators will provide web-based educational sessions to ultrasound operators and adjudicate image acquisition and interpretation. The primary outcome will be RRT or death within 28 days of septic shock. We will assess the hazard of RRT or death as a function of venous congestion using a Cox proportional hazards model. Sub-distribution HRs will describe the hazard of RRT given the competing risk of death. ETHICS AND DISSEMINATION: We obtained ethics approval for the AS-2 RCT, including this observational substudy, from local ethics boards at all participating sites. We will report the findings of this study through open-access publication, presentation at international conferences, a coordinated dissemination strategy by investigators through social media, and an open-access workshop series in multiple languages. TRIAL REGISTRATION NUMBER: NCT05057611.</p

Le Forum, Vol. 42 No. 1

https://digitalcommons.library.umaine.edu/francoamericain_forum/1094/thumbnail.jp

Age-Related Interactions with Wind During Migration Support the Hypothesis of Developmental Learning in a Migrating Long-Lived Seabird

Wind patterns shape migratory pathways and detours of many procellariiform bird species that seasonally migrate between hemispheres. These seabirds are long-lived, and the period of immaturity is presumed to be a time of development and learning the environment, specifically how to use wind to their advantage. We assess how wind encountered by individual Great Shearwaters (Ardenna gravis) varies along the migration journey and compare responses between presumed mature and immature birds (early and late, respectively) in southbound migration and mature birds in northbound migration. We analyze modeled Argos locations from 71 individual tracks of migratory Great Shearwaters with concurrent U (East/West) and V (North/South) wind components. Migration in seabirds is well studied, but there is limited quantitative work measuring individual birds directly interacting with wind and their associated changes in flight behavior during migration. We show that Great Shearwaters made optimal use of winds, and that different age groups made decisions that exposed them to different wind constraints. Overall, Great Shearwaters derived positive responses from wind under most conditions and did not rely on a drifting strategy, which would be suggested if wind effect (difference between ground and airspeed) was predominantly positive during migrations. Instead, they appeared to use a compensating strategy to achieve an acceptable course and speed. The difference we observed in migration phenologies suggests that by migrating later, immature birds might travel the path of least resistance and experience flight conditions that are less risky furthering their ability to withstand a variety of wind conditions encountered later in life as done by adults, which migrate earlier and are subject to more variable flight conditions. We conclude that like other procellariiforms, a longer period of sexual maturity is required to enhance flight performance and mediate energy expenditure through experiential learning and increased fitness

Comparison of Proteomic Assessment Methods in Multiple Cohort Studies

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/155922/1/pmic13292_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/155922/2/pmic13292.pd

Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COPD

BACKGROUND: Soluble receptor for advanced glycation end products (sRAGE) is a proposed emphysema and airflow obstruction biomarker; however, previous publications have shown inconsistent associations and only one study has investigate the association between sRAGE and emphysema. No cohorts have examined the association between sRAGE and progressive decline of lung function. There have also been no evaluation of assay compatibility, receiver operating characteristics, and little examination of the effect of genetic variability in non-white population. This manuscript addresses these deficiencies and introduces novel data from Pittsburgh COPD SCCOR and as well as novel work on airflow obstruction. A meta-analysis is used to quantify sRAGE associations with clinical phenotypes. METHODS: sRAGE was measured in four independent longitudinal cohorts on different analytic assays: COPDGene (n = 1443); SPIROMICS (n = 1623); ECLIPSE (n = 2349); Pittsburgh COPD SCCOR (n = 399). We constructed adjusted linear mixed models to determine associations of sRAGE with baseline and follow up forced expiratory volume at one second (FEV1) and emphysema by quantitative high-resolution CT lung density at the 15th percentile (adjusted for total lung capacity). RESULTS: Lower plasma or serum sRAGE values were associated with a COPD diagnosis (P < 0.001), reduced FEV1 (P < 0.001), and emphysema severity (P < 0.001). In an inverse-variance weighted meta-analysis, one SD lower log10-transformed sRAGE was associated with 105 ± 22 mL lower FEV1 and 4.14 ± 0.55 g/L lower adjusted lung density. After adjusting for covariates, lower sRAGE at baseline was associated with greater FEV1 decline and emphysema progression only in the ECLIPSE cohort. Non-Hispanic white subjects carrying the rs2070600 minor allele (A) and non-Hispanic African Americans carrying the rs2071288 minor allele (A) had lower sRAGE measurements compare to those with the major allele, but their emphysema-sRAGE regression slopes were similar. CONCLUSIONS: Lower blood sRAGE is associated with more severe airflow obstruction and emphysema, but associations with progression are inconsistent in the cohorts analyzed. In these cohorts, genotype influenced sRAGE measurements and strengthened variance modelling. Thus, genotype should be included in sRAGE evaluations

Systemic Markers of Lung Function and Forced Expiratory Volume in 1 Second Decline across Diverse Cohorts.

Rationale: Chronic obstructive pulmonary disease (COPD) is a complex disease characterized by airway obstruction and accelerated lung function decline. Our understanding of systemic protein biomarkers associated with COPD remains incomplete. Objectives: To determine what proteins and pathways are associated with impaired pulmonary function in a diverse population. Methods: We studied 6,722 participants across six cohort studies with both aptamer-based proteomic and spirometry data (4,566 predominantly White participants in a discovery analysis and 2,156 African American cohort participants in a validation). In linear regression models, we examined protein associations with baseline forced expiratory volume in 1 second (FEV1) and FEV1/forced vital capacity (FVC). In linear mixed effects models, we investigated the associations of baseline protein levels with rate of FEV1 decline (ml/yr) in 2,777 participants with up to 7 years of follow-up spirometry. Results: We identified 254 proteins associated with FEV1 in our discovery analyses, with 80 proteins validated in the Jackson Heart Study. Novel validated protein associations include kallistatin serine protease inhibitor, growth differentiation factor 2, and tumor necrosis factor-like weak inducer of apoptosis (discovery β = 0.0561, Q = 4.05 × 10-10; β  = 0.0421, Q = 1.12 × 10-3; and β = 0.0358, Q = 1.67 × 10-3, respectively). In longitudinal analyses within cohorts with follow-up spirometry, we identified 15 proteins associated with FEV1 decline (Q &lt; 0.05), including elafin leukocyte elastase inhibitor and mucin-associated TFF2 (trefoil factor 2; β = -4.3 ml/yr, Q = 0.049; β = -6.1 ml/yr, Q = 0.032, respectively). Pathways and processes highlighted by our study include aberrant extracellular matrix remodeling, enhanced innate immune response, dysregulation of angiogenesis, and coagulation. Conclusions: In this study, we identify and validate novel biomarkers and pathways associated with lung function traits in a racially diverse population. In addition, we identify novel protein markers associated with FEV1 decline. Several protein findings are supported by previously reported genetic signals, highlighting the plausibility of certain biologic pathways. These novel proteins might represent markers for risk stratification, as well as novel molecular targets for treatment of COPD