Design and characterisation of the new CIS115 sensor for JANUS, the high resolution camera on JUICE

JUICE, the Jupiter Icy Moon Explorer, is a European Space Agency L-class mission destined for the Jovian system. Due for launch in 2022, it will begin a science phase after its transit to Jupiter that will include detailed investigations of three of the Galilean moons: Ganymede, Callisto and Europa. JUICE will carry payloads to characterise the Jovian environments, divided into in situ, geophysical and remote sensing packages. A key instrument in the remote sensing package is JANUS, an optical camera operating over a wavelength range of 350 nm to 1064 nm. JANUS will be used to study the external layers of Jupiter’s atmosphere, the ring system and the planetary bodies. To achieve the science goals, resolutions of better than 5 m per pixel are required for the highest resolution observations during the 200 km altitude orbit of Ganymede, whilst the system is operated with a signal to noise ratio of better than 100. Jupiter’s magnetic field is a dominant object in the solar system, trapping electrons and other charged particles leading to the radiation environment around Jupiter being very hostile, especially in the regions closest to Jupiter in the Ganymede orbit. The radiation tolerance of the focal plane detector in JANUS is therefore a major concern and radiation testing is vital to confirm its expected performance after irradiation will meet requirements set by the science goals. JANUS will be using a detector from e2v technologies plc, the CMOS Imaging Sensor 115 (CIS115), which is a device manufactured using 0.18 μm Imaging CMOS Process with a 2000 by 1504 pixel array each 7 μm square. The pixels have a 4T pinned photodiode pixel architecture, and the array is read out through four differential analogue outputs. This paper describes the preliminary characterisation of the CIS115, and results obtained with the CIS107 precursor sensor

A global shutter CMOS image sensor for hyperspectral imaging

Hyperspectral imaging has been providing vital information on the Earth landscape in response to the changing environment, land use and natural phenomena. While conventional hyperspectral imaging instruments have typically used rows of linescan CCDs, CMOS image sensors (CIS) have been slowly penetrating space instrumentation for the past decade, and Earth observation (EO) is no exception. CIS provide distinct advantages over CCDs that are relevant to EO hyperspectral imaging. The lack of charge transfer through the array allows the reduction of cross talk usually present in CCDs due to imperfect charge transfer efficiency, and random pixel addressing makes variable integration time possible, and thus improves the camera sensitivity and dynamic range. We have developed a 10T pixel design that integrates a pinned photodiode with global shutter and in-pixel correlated double sampling (CDS) to increase the signal to noise ratio in less intense spectral regimes, allowing for both high resolution and low noise hyperspectral imaging for EO. This paper details the characterization of a test device, providing baseline performance measurements of the array such as noise, responsivity, dark current and global shutter efficiency, and also discussing benchmark hyperspectral imaging requirements such as dynamic range, pixel crosstalk, and image lag

Development of a photon-counting near-fano-limited x-ray CMOS image sensor for THESEUS' SXI

THESEUS (Transient High Energy Sky & Early Universe Surveyor) is one of the three candidates for the M5 mission of the European Space Agency. The favoured mission will be announced in 2021 for an expected launch in 2032. THESEUS will be equipped with a Soft X-ray Imager (SXI) composed of a set of two telescopes using micro-pore optics offering an overall field of view of 0.5 sr (<2' accuracy) for X-ray energies between 300 eV and 5 keV. The focal plane of each SXI telescope has a 16 x 16 cm² cooled detector area. However, the limited radiator accommodation on the spacecraft prohibits the use of CCDs since cooling the focal planes to an optimal temperature for radiation hardness (<-100 °C) is not feasible. Therefore, the development of a suitable CMOS Image Sensor (CIS), capable of handling the expected levels of radiation at higher operating temperatures (approximately -30 °C) has been proposed. To demonstrate the performance required for the THESEUS SXI detector, a 2 x 2 cm² prototype is under development using Open University pixel designs in a Teledyne-e2v digital CMOS platform. The pixel design will allow full depletion over silicon thickness of 35 µm for optimal soft X-ray quantum efficiency and instrument background suppression, and will be capable of near-Fano-limited spectral resolution that will also be of prime interest for synchrotron and Free Electron Lasers (FEL) applications. In this paper, we will present the design considerations and simulations leading to the implemented structures complying with THESEUS' SXI requirements

First Detection of Leishmania major DNA in Sergentomyia (Spelaeomyia) darlingi from Cutaneous Leishmaniasis Foci in Mali

Leishmania major complex is the main causative agent of zoonotic cutaneous leishmaniasis (ZCL) in the Old World. Phlebotomus papatasi and Phlebotomus duboscqi are recognized vectors of L. major complex in Northern and Southern Sahara, respectively. In Mali, ZCL due to L. major is an emerging public health problem, with several cases reported from different parts of the country. The main objective of the present study was to identify the vectors of Leishmania major in the Bandiagara area, in Mali. Methodology/Principal Findings: An entomological survey was carried out in the ZCL foci of Bandiagara area. Sandflies were collected using CDC miniature light traps and sticky papers. In the field, live female Phlebotomine sandflies were identified and examined for the presence of promastigotes. The remaining sandflies were identified morphologically and tested for Leishmania by PCR in the ITS2 gene. The source of blood meal of the engorged females was determined using the cyt-b sequence. Out of the 3,259 collected sandflies, 1,324 were identified morphologically, and consisted of 20 species, of which four belonged to the genus Phlebotomus and 16 to the genus Sergentomyia. Leishmania major DNA was detected by PCR in 7 of the 446 females (1.6%), specifically 2 out of 115 Phlebotomus duboscqi specimens, and 5 from 198 Sergentomyia darlingi specimens. Human DNA was detected in one blood-fed female S. darlingi positive for L. major DNA. Conclusion: Our data suggest the possible involvement of P. duboscqi and potentially S. darlingi in the transmission of ZCL in Mali

e2v new CCD and CMOS technology developments for astronomical sensors

ABSTRACT We present recent development in the technology of silicon sensors for astronomical applications. Novel CCD and CMOS sensors have been designed for low noise and high sensitivity astronomical use. High resistivity sensors allow thicker silicon for higher red sensitivity in several types of new CCD. The capability to manufacture large sets of CCDs to form large focal planes has allowed several very large mosaics to be built for astronomy with increasing formats on the ground and in space. In addition to supplying sensors we discuss increasing capacity and interest in the commercial supply of integrated &quot;camera&quot; systems

Twenty-four new human cases of cutaneous leishmaniasis due to Leishmania killicki in Metlaoui, southwestern Tunisia. Probable role of Phlebotomus sergenti in the transmission

International audienceMetlaoui district in the South-west of Tunisia is a classical focus of cutaneous leishmaniasis (CL) due to Leishmania major. Since 2005, a single case of CL due to L. killicki has been reported. We report twenty four human cases due to this parasite, affecting men and women from 2 to 70 years old. Leishmania killicki have been typed using molecular techniques: polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) and gene sequencing. Four strains from patients have been successfully cultured on NNN medium and isoenzymatically typed as L. killicki MON-8. Our results strongly suggests that Metlaoui is a new L. killicki focus with a stable transmission cycle. Sand flies fauna in the same focus was also studied. 1400 Phlebotomine sand flies (785 males/615 females) have been caught during an entomological survey. Leishmania major DNA has been found in one P. papatasi female, the most abundant species, whereas L. killicki DNA has been found in one Phlebotomus sergenti female emphasizing the probable role of this species as vector of this zoonotic parasite

Comments on Leishmania major in Gorilla Feces

To the Editor—As a group of experts with a long-term experience working in the field of leishmaniasis research, we wish to comment on the highly original finding by Hamad et al about the presence of Leishmania major promastigotes and amastigotes in gorilla feces in southern Cameroon

A CMOS image sensor for soft x-ray astronomy

A monolithic CMOS image sensor based on the pinned photodiode (PPD) and optimized for X-ray imaging in the 300 eV to 5 keV energy range is described. Featuring 40 µm square pixels and 40 µm thick, high resistivity epitaxial silicon, the sensor is fully depleted by reverse substrate bias. Backside illumination (BSI) processing has been used to achieve high X-ray QE, and a dedicated pixel design has been developed for low image lag and high conversion gain. The sensor, called CIS221-X, is manufactured in a 180 nm CMOS process and has three different 512×128-pixel arrays on 40 µm pitch, as well as a 2048×512 array of 10 µm pixels. CIS221-X also features per-column 12-bit ADCs, digital readout via four high-speed LVDS outputs, and can be read out at 45 frames per second. CIS221-X achieves readout noise of 2.6 e- RMS and full width at half maximum (FWHM) at the Mn-Kα 5.9 keV characteristic X-ray line of 153 eV at -40 °C. This paper presents the characterization results of the first backside illuminated CIS221-X, including X-ray response and readout noise. The newly developed sensor and the technology underpinning it is intended for diverse applications, including X-ray astronomy, synchrotron, and X-ray free electron laser light sources