EFFECT OF NISTHUSHAYADIKWATHA AND PHALATRIKADI KWATHA IN AMLAPITHA– A RANDOMISED COMPARATIVE CLINICAL STUDY

Amlapitta may be a clinical entity manifesting within the Annavaha Srotas. Kashyapa and Madhava have described this disease thoroughly. Amlapitta has become quite common because of the change within the food and life styles, sophistication and a stressful life. It is characterized by Avipaka, Klama, Tiktodhgara, Amlodhgara, Gaurava, Hritkanthadaha and Aruchi indicating the Vikruthi of Pachakapitta, Kledakakapha and Samanavata. The etiological factors and therefore the symptomatology manifested relate Amlapitta to diseases mentioned under Acid Peptic Disorders. Nistushayadi Kwatha and Phalatrikadi kwatha were selected. The main objectives of the study are to study and compare the effect of Nistushayadi Kwatha and effect of Phalatrikadi kwatha in the management of Amlapitta. A total of 40 patients who fulfilled the inclusion criteria were selected, and randomly assigned into two groups i.e., Group A and Group B, comprising of 20 patients each. Group A and Group B were administered Nistushayadi kwatha and Phalatrikadi Kwatha respectively for 30 days. Both the groups were advised Pathya Ahara. They were followed up after every 10th days. After the intervention the Samanya Lakshana of Amlapitta were observed, recorded and assessed. The overall assessment of both the groups, where group A receives Nistushyadi kwatha and group B Phalatrikadi kwatha shows promising improvement in the subjective parameters. Assessment was done using unpaired ‘t’ test between these two groups, the result was not quite statistically significant which means there is no much difference in the efficacy of these two formulation in the management of Amlapitta. Both the formulations shown nearly same outcome in the improvement of disease parameter. The reduction in the symptoms were started to be noticed by 7th day where the patients had reduction in Hrutkantha Daha, Aruchi, Kanthadaha and Angagourav. These symptoms resolved by 30th day

Oral Candidiasis Review: Pathogenesis, Clinical Presentation, And Treatment Strategies

The candidiasis is an opportunistic infection commonly affecting the oral cavity. The most prevalent clinical symptoms of candidiasis seen in medical and dental practice is oral candidiasis. People who are extremely young, elderly, or already ill are more likely to develop the illness. The present review summarize classification, pathophysiology, laboratory diagnosis and treatment and management of oral candidiasis. Additionally, medicinal herbs and nutraceuticals can be explored as a safe, accessible, and cost-effective therapy option for oral candidiasi

Oral Candidiasis Review: Pathogenesis, Clinical Presentation, And Treatment Strategies

The candidiasis is an opportunistic infection commonly affecting the oral cavity. The most prevalent clinical symptoms of candidiasis seen in medical and dental practice is oral candidiasis. People who are extremely young, elderly, or already ill are more likely to develop the illness. The present review summarize classification, pathophysiology, laboratory diagnosis and treatment and management of oral candidiasis. Additionally, medicinal herbs and nutraceuticals can be explored as a safe, accessible, and cost-effective therapy option for oral candidiasis

CONTRIBUTION OF ACHARYA NAGARJUNA IN SUSRUTA SAMHITA: A REVIEW

Acharya Nagarjuna was a famous Buddhist Alchemist. Research scholars have faith in more than one Nagarjuna who contributed in the field of philosophy, alchemy, medical and Tantra and few scholars supporting for only one Nagarjuna who as expert in all subjects. In Ayurveda fraternity, it is general belief that Acharya Nagarjuna has composed the Uttarasthana (Uttaratantra) of Susruta Samhita but there are some references which indicates that Acharya Nagarjuna has contributed in Purvardha also. In Uttarasthana (Uttaratantra) of Susruta Samhita there has not mentioned any Alchemy whereas in Maha Kushtha Chikitsa (Purvardha), Ayaskriti has been used which clearly indicates that Acharya Nagarjuna has not only contributed in the Uttarasthan but also in the Purvardha of Susruta Samhita. Balagraha, Kayachikitsa and Bhutavidya have been described in the Uttarsthana of Susruta Samhita. There are many literatures available in Buddhism which has been contributed by Acharya Nagarjuna. If we are having deep knowledge of the Buddhist literature such as Mulmadhyamikakarika, Yuktisastika etc. which has been contributed by Acharya Nagarjuna then it will be easy to know the exact contribution of Acharya Nagarjuna in Susruta Samhitaas well as in Ayurveda. This article deals with the historical study of Acharya Nagarjuna, a great personality and his contribution in Susruta Samhita

Non valvular atrial fibrillation stroke risk stratification by CHA2DS2-VASc score and short term outcomes

Background: Atrial fibrillation confers a high risk of stroke and is associated with significant mortality and morbidity. Many scoring systems for have been proposed stroke risk stratification in atrial fibrillation. Peripheral thromboembolism, heart failure and death. The main objective of the study was to estimate CHA2DS2VASc score in cases of non valvular atrial fibrillation, to asses short term outcome in AF (stroke, thromboembolism, heart failure and death and to find out association of CHA2DS2VASc score with outcomes.Methods: 64 cases (29 M, 35 F) of non valvular AF were included in this prospective observational study.CHA2DS2VASc score was calculated and cases were categorized into low (score 0), intermediate (score 1 ) and high risk (score 2 ) for development of stroke. Cases were clinically evaluated and investigated for type, etiology, complications and comorbidities.Results: CHA2DS2VASc score was determined in 64 cases of non valvular AF. In 3 cases (4.6%) it was zero indicating low risk for stroke, 8 cases (12.5%) had CHA2DS2VASc score as 1had intermediate risk, and 53 cases (82.8%) had score 2 or more indicating high stroke risk (p<0.01). 3 cases of non valvular atrial fibrillation (4.6%) presented with stroke and all of them had CHA2DS2VASc score>2. At the end of 3 months, total no. of cases with stroke was reported to be 5 (7.8 %). Stroke risk was significantly higher in cases of CHA2DS2VASc score>2 (p<0.01). Congestive heart failure was reported in 32 (50%) cases. Peripheral embolism was documented in 1 case (1.5%). Overall Mortality at the end of 3 months was reported to be 7 (10.9%) and cases with CHA2DS2VASc score ≥2 had 13% mortality. CHA2DS2VASc score ≥2 was significantly associated with mortality (p<0.01). All 3 Cases with CHA2DS2VASc score as zero were uncomplicated. 8 cases (12.5%) had score as 1 and, out of these 8 cases, CHF was reported in 2 cases (25%), while 6 (75%) were uncomplicated.CHA2DS2VASc score ≥2 was reported in 53 cases (82.3%). This group had complications in the form of CHF in 30 cases (56.6 %), thromboembolism in 1 (1.8%), and stroke in 5 (9.4%) cases. Cases of AF with CHA2DS2VASc score >2 demonstrated significantly high incidence for stroke as compared to those with score as zero or one (p<0.01).Conclusions: CHA2DS2VASc is a simple score to predict stroke risk in cases of non valvular atrial fibrillation and is easy to estimate. CHA2DS2VASc score ≥2; is associated with high incidence of stroke in cases of non valvular AF. CHA2DS2VASc score≥2 is associated with mortality as a short term adverse outcome in non valvular atrial fibrillation.

LAN Monitoring Using Android Phone

ABSTRACT: Now a day's android phones are used for the various applications. We can use android phone for monitor and control the network. It is to control the network when network admin is in admin office but it is difficult to control the network from outside the office. It is integrated software solution that allows a network admin to remotely monitor his LAN network by his Android phone with GUI. The main purpose of this application is to provide all the important details of the network to the admin on their android phone with the help of GPRS or Wi-Fi. We are using data connectivity or Wi-Fi to connect the mobile phone to LAN server. And we also are using password encryption for authentication in phone

Synthesis, molecular docking and biological evaluation of new quinoline analogues as potent anti-breast cancer and antibacterial agents

1215-1222A new class of quinoline analogues have been synthesized from isatin through two steps in good yields. They have been further evaluated for their anticancer activity against a breast cancer cell line (MDA-MB-231) and antibacterial activity against Gram-positive bacteria (Staphylococcus aureus 6538p and Bacillus subtilis) and Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa). All synthesized compounds have been confirmed by spectral characterization viz. FT-IR, MS, HPLC, 1H and 13C NMR. Among them, compound 4h exhibits promising anti-breast cancer activity whereas compounds 4d, 4f, 4h and 4j exhibit moderate antibacterial activity against all the tested organisms. Molecular docking analysis demonstrates the interaction of compound 4h with the active site amino acid of Human Carbonic Anhydrase I, Protein Kinase A and Kinesin Spindle Protein (KSP)

Synthesis, molecular docking and biological evaluation of new quinoline analogues as potent anti-breast cancer and antibacterial agents

A new class of quinoline analogues have been synthesized from isatin through two steps in good yields. They have been further evaluated for their anticancer activity against a breast cancer cell line (MDA-MB-231) and antibacterial activity against Gram-positive bacteria (Staphylococcus aureus 6538p and Bacillus subtilis) and Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa). All synthesized compounds have been confirmed by spectral characterization viz. FT-IR, MS, HPLC, 1H and 13C NMR. Among them, compound 4h exhibits promising anti-breast cancer activity whereas compounds 4d, 4f, 4h and 4j exhibit moderate antibacterial activity against all the tested organisms. Molecular docking analysis demonstrates the interaction of compound 4h with the active site amino acid of Human Carbonic Anhydrase I, Protein Kinase A and Kinesin Spindle Protein (KSP).

Progress on Thin Film Freezing Technology for Dry Powder Inhalation Formulations

The surface drying process is an important technology in the pharmaceutical, biomedical, and food industries. The final stage of formulation development (i.e., the drying process) faces several challenges, and overall mastering depends on the end step. The advent of new emerging technologies paved the way for commercialization. Thin film freezing (TFF) is a new emerging freeze-drying technique available for various treatment modalities in drug delivery. TFF has now been used for the commercialization of pharmaceuticals, food, and biopharmaceutical products. The present review highlights the fundamentals of TFF along with modulated techniques used for drying pharmaceuticals and biopharmaceuticals. Furthermore, we have covered various therapeutic applications of TFF technology in the development of nanoformulations, dry powder for inhalations and vaccines. TFF holds promise in delivering therapeutics for lung diseases such as fungal infection, bacterial infection, lung dysfunction, and pneumonia

A rare myoepithelioma of the sinonasal cavity: case report

Myoepithelioma is a rare benign neoplasm. Pure accounting for less than 1% of all salivary gland tumors. Only three cases of sinonasal myoepithelioma have been reported in the literature. Diagnosis of myoepithelioma through light microscopy is possible and immunohistochemistry is done to facilitate the diagnosis. The lesion is so rare that there are no specific indications/guidelines for its treatment. We report to you a rare case of sinonasal myoepithelioma in a 57 year old Asian female