148 research outputs found

    The Effect of Inlet Pulsations on Primary Atomization of Liquid Jets

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    Objectives Elucidate the physics underlying the primary atomization of liquid jets. Investigate the effect of inlet pulsations on the atomization process. Identify the reliability of numerical predictions using uncertainty quantification techniques (UQ) and sensitivity analyses

    High-Fidelity Simulations of Water Jet in Air Crossflow

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    Objectives Investigate detailed physics underlying liquid jets in crossflow configurations applicable to various applications such as, gas-turbine, scramjet, and afterburner fuel injection. Develop models to predict the statistical behaviors of resulting droplets

    Detection of Alzheimer’s Disease using CNN Architectures

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    Alzheimer’s disease is a neurological condition that causes some structural alterations in the brain. In this paper we have given an overview of all the available good CNN models used in medical imaging for image classification purpose such asAlexNet, GoogleNet, ResNet 18, ResNet 50, SqueezeNet and DenseNet. Using these CNN models, we have been able to classify three different stages of Alzheimer's disease – Cognitively Normal (NC), Mild Cognitive Impairment (MCI) and Alzheimer’s Disease(AD). The dataset is derived from ADNI and has been preprocessed before applying various CNN models. The experimental results demonstrate that all models performed well and the best accuracy has been acquired by the GoogleNet of 96.81%

    Cross-Lingual Classification of Crisis Data

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    Many citizens nowadays flock to social media during crises to share or acquire the latest information about the event. Due to the sheer volume of data typically circulated during such events, it is necessary to be able to efficiently filter out irrelevant posts, thus focusing attention on the posts that are truly relevant to the crisis. Current methods for classifying the relevance of posts to a crisis or set of crises typically struggle to deal with posts in different languages, and it is not viable during rapidly evolving crisis situations to train new models for each language. In this paper we test statistical and semantic classification approaches on cross-lingual datasets from 30 crisis events, consisting of posts written mainly in English, Spanish, and Italian. We experiment with scenarios where the model is trained on one language and tested on another, and where the data is translated to a single language. We show that the addition of semantic features extracted from external knowledge bases improve accuracy over a purely statistical model

    Antileishmanial potential of a marine sponge Haliclona oculata against experimental visceral leishmaniasis

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    Objective: To evaluate the antileishmanial activity of a marine sponge Haliclona oculata. Methods: The crude methanol extract was prepared from the freshly collected sponge and its three fractions were also prepared by maceration method. The antileishmanial activity of these extract and fractions was tested against Leishmania donovani. Results: The antileishmanial activity was tested both in vitro and in vivo. The crude methanol extract exerted almost complete inhibition of promastigotes (81.0% ± 6.9%) and 78.8% ± 5.2% inhibition of intracellular amastigotes at 100 μg/mL with IC50 values of 29.5 μg/mL and 40.6 μg/mL, respectively. The treatment of 500 mg/kg (p.o.) of the crude methanol extract for 5 d for Leishmania donovani infected hamsters resulted in 78.35% ± 10.20% inhibition of intracellular amastigotes. At a lower dose (250 mg/kg), it exhibited poor efficacy. Among the fractions, highest in vitro (>75%) and in vivo (84.3% ± 10.2%) antileishmanial activity was observed in n-chloroform fraction with IC50 values of 54.2 μg/mL and 61 μg/mL against promastigotes and intracellular amastigotes, respectively. Hexane fraction and n-butanol (both insoluble and soluble) fractions were found inactive in vitro and in vivo. Conclusions: Our findings indicate that this marine sponge has the potential to provide new insight toward development of an effective antileishmanial agent and, hence, more exhaustive studies are needed for exploiting the vast marine resources of the world to combat the scourge of several parasitic diseases

    Impact of oral palonosetron in improving quality of life as compared to other oral 5-HT3 antagonists in delayed chemotherapy induced nausea and vomiting in patients of head and neck cancer

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    Background: Chemotherapy induced nausea and vomiting (CINV) remains one of the most common and debilitating complications of highly emetogenic chemotherapy (HEC). This study was undertaken to evaluate palanosetron against other 5-HT3 receptor antagonists in preventing delayed CINV with the aim of achieving complete response (CR) and improving quality of life (QoL).Methods: This was a prospective, observational study conducted on 75 histopathologically proven patients of squamous cell carcinoma of Head and Neck (H&N), who came to the Department of Radiation Oncology, Gandhi Medical College and Hamidia Hospital, Bhopal from January to December 2015. Standard protocol based chemotherapy containing highly emetogenic cisplatin based chemotherapy was administered to all the patients. For prevention of delayed chemotherapy induced nausea and vomiting all patients were prescribed oral 5-HT3 antagonists. Oral Ondansetron 4mg TDS was given to cohort 1, oral Granisetron 1 mg BD to cohort2 and oral Palanosetron 0.5mg OD was given to cohort 3. They were graded as complete response when they did not have complains of nausea and vomiting.Results: In Ondansetron, Granisetron and in Palanosetron cohort 29%, 53% and 98% patients had complete response.Conclusions: Palanosetron appears superior. Our study was conducted on handfull of patients and compared palanosetron against only two 5-HT3 receptor antagonists, so a larger study is suggested to establish the efficacy and better response of palanosetron
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