Multivariable H-Function with Application to Temperature Distribution in a Moving Medium

The Meijer's G-function has been obtained for the first time as a solution of a differential equation governing a heat conduction problem. The problem of temperature distribution in a moving medium between x = - 1 and x = 1 and having variable velocity and variable thermal conductivity is considered. Due to a general character of the G-function, many known and unknown results may be derived as particular cases. The modified multivariable H-function to obtain a particular solution has been employed

The expanding phenotype of MELAS caused by the m.3291T \u3e C mutation in the MT-TL1 gene

Crown Copyright © 2016 Published by Elsevier Inc. m.3291T \u3e C mutation in the MT-TL1 gene has been infrequently encountered in association with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS), however remains poorly characterized from a clinical perspective. In the following report we describe in detail the phenotypic features, long term follow up (\u3e 7 years) and management in a Caucasian family with MELAS due to the m.3291T \u3e C mutation and review the literature on m.3291T \u3e C mutation. The clinical phenotype in the proposita included overlapping features of MELAS, MERRF (Myoclonic epilepsy and ragged-red fiber syndrome), MNGIE (Mitochondrial neurogastrointestinal encephalopathy), KSS (Kearns-Sayre Syndrome) and CPEO (Chronic progressive external ophthalmoplegia)

MELAS: A multigenerational impact of the MTTL1 A3243G MELAS mutation

Background: the maternally inherited MTTL1 A3243G mutation in the mitochondrial genome causes MelaS (Mitochondrial encephalopathy lactic acidosis with Stroke-like episodes), a condition that is multisystemic but affects primarily the nervous system. Significant intra-familial variation in phenotype and severity of disease is well recognized. Methods: retrospective and ongoing study of an extended family carrying the MTTL1 A3243G mutation with multiple symptomatic individuals. tissue heteroplasmy is reviewed based on the clinical presentations, imaging studies, laboratory findings in affected individuals and pathological material obtained at autopsy in two of the family members. Results: there were seven affected individuals out of thirteen members in this three generation family who each carried the MTTL1 A3243G mutation. the clinical presentations were varied with symptoms ranging from hearing loss, migraines, dementia, seizures, diabetes, visual manifestations, and stroke like episodes. three of the family members are deceased from MelaS or to complications related to MelaS. Conclusions: the results of the clinical, pathological and radiological findings in this family provide strong support to the current concepts of maternal inheritance, tissue heteroplasmy and molecular pathogenesis in MelaS. neurologists (both adult and paediatric) are the most likely to encounter patients with MelaS in their practice. genetic counselling is complex in view of maternal inheritance and heteroplasmy. newer therapeutic options such as arginine are being used for acute and preventative management of stroke like episodes. © 2014 Canadian Journal of neurologiCal sciences inc

Potential impact and controversy of stem cells in public health

Stem cells are versatile in the bodies which are able to both reproduce themselves and to produce more specialized cells. As such, they are of great potential values in repairing and regenerating damaged cells and tissues. Many different kinds of stem cells have been discovered. The most common are embryonic, foetal and adult stem cells. Stem cell research has the potential to provide an increased understanding of development and differentiation, as well as leading to treatments and cures for many diseases. They are important to the future of medicine and public health because with adequate research, stem cells have the potential to treat degenerative conditions through transplanting human stem cells into patients. With sufficient development of stem cell medicine, chronic diseases such as diabetes, heart disease, and Parkinson’s disease will be effectively managed. Embryonic stem cell (ESC) research has been a source of ethical, legal, and social controversy which has slowed the pace of stem cell science and shaped many aspects of its subsequent development

Effect of Paclobutrazol on Fruit Quality Attributes in Mango (Mangifera indica L.) Cv. Totapuri

Paclobutrazol application restricts vegetative growth while improving flowering and fruiting in mango. In the present study, effect of soil drenching with Paclobutrazol @ 3.0ml m-1 canopy diameter, applied during the 3rd week of August, on fruit quality attributes was investigated in cv. Totapuri. Parameters like fruit weight, total soluble solids (TSS), % acidity, and content of ascorbic acid, carotenoids, lycopene and individual sugars was estimated. Paclobutrazol application increased average fruit weight, TSS and content of ascorbic acid and total carotenoids, and reduced the acidity in fruits compared to fruits in untreated trees. Lycopene content was only marginally influenced by paclobutrazol. In fruits of paclobutrazol treated trees, increase of 23.4% in total sugars, 29.6% in reducing sugars, 77.4% in glucose and 27.8% in sucrose content was recorded over fruits from the untreated trees. Results indicated that, paclobutrazol application improved quality in mango fruit

A New Approach for SAR Image Denoising

In synthetic aperture radar (SAR)  imaging, the transmitted pulses from space born antenna interacts with ground objects and returned energy or back scattered energy will be collected  to get backscattered image. In this process, a speckle noise will be added because of the coherent imaging system and  makes the study of SAR images very difficult. For better SAR image processing, the speckle has to be removed in the initial stages of processing  and maintain all texture features efficiently. The BM3D method is generally considered as state of art method in denoising of SAR images. In this paper, it is proposed a technique to despeckle the speckle noise to the maximum extent while maintaining the edge characteristics

Case of Multiple Sulfatase Deficiency and Ocular Albinism: A Diagnostic Odyssey

Background: Multiple sulfatase deficiency (MSD) is a rare autosomal recessive inborn error of lysosomal metabolism. The clinical phenotypic spectrum encompasses overlapping features of variable severity and is suggestive of individual single sulfatase deficiencies (i.e., metachromatic leukodystrophy, mucopolysaccharidosis, and X-linked ichthyosis). Case Report: We describe a 3-year-old male with severe hypotonia, developmental regression and progressive neurodegeneration, coarse facial features, nystagmus (from ocular albinism), and dysmyelinating motor sensory neuropathy. Ethics approval was obtained from the Western University Ontario. Results: Extensive investigative work-up identified deficiencies of multiple sulfatases: heparan sulfate sulfamidase: 6.5 nmoles/mg/protein/17 hour (reference 25.0-75.0), iduronate-2-sulfate sulfatase: 9 nmol/mg/protein/4 hour (reference 31-110), and arylsulfatase A: 3.8 nmoles/hr/mg protein (reference 22-50). The identification of compound heterozygous pathogenic mutations in the SUMF1 gene c.836 C\u3eT (p.A279V) and c.1045C\u3eT (p.R349W) confirmed the diagnosis of MSD. Conclusion: The complex clinical manifestations of MSD and the unrelated coexistence of ocular albinism as in our case can delay diagnosis. Genetic counselling should be provided to all affected families