Perbedaan Efek Seduhan Kulit Dan Jus Buah Naga Merah (Hylocereus Polyrhizus) Terhadap Kadar Trigliserida Serum Tikus Sprague Dawley Dislipidemia

Latar Belakang : Dislipidemia merupakan abnormalitas profil lipid dalam serum, salah satunya adalah peningkatan kadar trigliserida serum. Buah naga merah (Hylocereus polyrhizus) terbukti memperbaiki profil lipid karena adanya kandungan fenolat dan flavonoid. Kulit buah naga merah mengandung kandungan gizi seperti karbohidrat, lemak, protein, serat dan senyawa betasianin.Tujuan : Mengetahui perbedaan efek pemberian seduhan kulit dan jus daging buah naga merah terhadap kadar trigliserida serum tikus Sprague dawley dislipidemia.Metode : Jenis penelitian adalah true experimental dengan pre and post test with control group design. Sampel adalah tikus jantan Sprague dawley usia 10 minggu, diinduksi dislipidemia dengan telur puyuh dan asam kolat. Pada kelompok K(-) diberi pakan standar, kelompok K(+) diberi pakan tinggi kolesterol, kelompok P1 diberi seduhan kulit buah naga merah dan kelompok P2 diberi jus buah naga merah. Kadar trigliserida serum diperiksa dengan metode CHOD-PAP dan GPO-PAP. Data kemudian dianalisis menggunakan uji paired t test dan one way ANOVA.Hasil : Terdapat perbedaan bermakna sebelum dan setelah intervensi pada kelompok K(-), K(+), P1 dan P2. Pemberian seduhan kulit selama 14 hari dapat menurunkan kadar trigliserida sebesar 53,61 mg/dl (SD= 4,06) sedangkan jus buah naga merah dapat menurunkan kadar trigliserida sebesar 36,99 mg/dl (SD= 8,14). Setelah intervensi terdapat perbedaan rerata kadar trigliserida antar kelompok p=0,000 kecuali K(-) dengan seduhan kulit p=1,000.Simpulan : Pemberian seduhan kulit buah naga merah dan jus daging buah naga merah selama 14 hari dengan dosis 9,08 g/200 gbb tikus dan 1,53 g/200 gbb tikus dapat menurunkan kadar trigliserida serum masing-masing sebesar 53,61 mg/dl (SD= 4,06) dan 36,99 mg/dl (SD= 8,14) pada tikus Sprague dawley dislipidemia

Maternal and Perinatal Outcomes of COVID-19 in Pregnant Women : Luaran Maternal dan Perinatal pada Ibu Hamil dengan COVID-19

Objective: To describe and identify risk factors of maternal and perinatal outcome of COVID-19 in pregnant women.Methods: Literature search was conducted on MEDLINE and Google Scholar databases for articles published in December 2020 to January 2021. Keywords used includes ‘COVID-19’, ‘pregnant women’, ‘maternal outcome’ and ‘fetal outcome.’ Critical appraisal and selection were conducted to identify articles that fulfill inclusion criteria. The selected articles were analyzed thematically to answer the research questions.Results: Literature search yielded 124 articles with 11 included in final analysis. The results showed low to moderate risk of maternal and perinatal adverse outcomes, including low risks for maternal and perinatal mortality coupled with moderate risk for maternal ICU admission and preterm birth with NICU admission for the newborn. Higher risk was observed for pregnant women with symptomatic COVID-19 infection, which points to the necessity for awareness of the risk and targeted early detection efforts.Conclusion: There are low risk for adverse maternal and perinatal outcomes, including mortality and ICU/NICU admission, associated with COVID-19 infection in pregnant women. Risk factors for adverse outcomes included pregnant women with symptomatic COVID-19 infection.Keywords:  COVID-19, ICU, maternal mortality, NICU, perinatal mortality, preterm birth Abstrak Tujuan: Mendeskripsikan dan mengidentifikasi faktor risiko luaran maternal dan perinatal COVID-19 pada ibu hamil.Metode: Penelusuran literatur dilakukan di database MEDLINE dan Google Scholar untuk artikel yang diterbitkan pada Desember 2020 hingga Januari 2021. Kata kunci yang digunakan meliputi 'COVID-19', 'wanita hamil', 'keluaran ibu' dan 'hasil janin'. Penilaian dan seleksi kritis dilakukan untuk mengidentifikasi artikel yang memenuhi kriteria inklusi. Artikel yang dipilih dianalisis secara tematis untuk menjawab pertanyaan penelitian.Hasil: Penelusuran literatur menghasilkan 124 artikel dengan 11 termasuk dalam analisis akhir. Hasil penelitian menunjukkan risiko rendah hingga sedang untuk luaran buruk maternal dan perinatal, termasuk risiko rendah untuk kematian maternal dan perinatal ditambah dengan risiko sedang untuk masuk ICU ibu dan kelahiran prematur dengan masuk NICU untuk bayi baru lahir. Risiko yang lebih tinggi diamati untuk wanita hamil dengan infeksi COVID-19 bergejala, yang menunjukkan perlunya kesadaran akan risiko dan upaya deteksi dini yang ditargetkan.Kesimpulan: Terdapat risiko rendah untuk laran buruk maternal dan perinatal, termasuk kematian dan rawat inap di ICU/NICU, terkait dengan infeksi COVID-19 pada wanita hamil. Faktor risiko untuk luaran buruk adalah wanita hamil dengan gejala infeksi COVID-19.Kata kunci: COVID-19, ICU, kelahiran preterm, mortalitas maternal, mortalitas perinatal, NIC

Uji Kelayakan Sinbiotik (Lactobacillus plantarum) dan Limbah Ekstraksi Temulawak) sebagai Upaya Produksi Sinbiotik Rendah Kolesterol

Tujuan dari penelitian ini adalah untuk mengetahui sinergitas simbiosis probiotik (L. plantarum) dan prebiotik (limbah ekstraksi temulawak), ketahanan L. plantarum terhadap bakteri patogen,pH asam dan garam empedu.Tiga puluh enam sampel probiotik dalam medium agar berisi limbah temulawak dengan persentase yang berbeda digunakan dalam uji daya hidup bakteri, Empat isolat bakteri L. plantarum digunakan dalam uji tantang bakteri dan enam isolat bakteri L. plantarum digunakan dalam uji ketahanan pH asam dan garam empedu. Data hasil penelitian daya hidup bakteri L. plantarum dianalisis menggunakan analisis varian, sedangkan parameter yang lain menggunakan analisis deskriptif kualitatif. Hasil penelitian menunjukkan jumlah koloni bakteri yang tumbuh pada persentase temulawak 1%, 2% dan 3 % berturut-turut adalah 0,8 x 108, 2,3 x 108 dan 1,3 x 108. Uji tantang bakteri L. plantarum terhadap Salmonella sp dan Staphylococcus sp. menunjukkan daya tahan yang baik. Uji ketahanan pH asam dan garam empedu menunjukkan ketahanan L. plantarum pada pH 1,5-6,5 dan garam empedu 1-6 mL. Kesimpulan dari penelitian ini adalah L. plantarum memiliki sinergitas simbiosis dengan limbah ekstraksi temulawak untuk menyusun sinbiotik rendah kolesterol. L. plantarum juga memiliki ketahanan terhadap bakteri Salmonella sp. dan Staphylococcus sp, pH 1,5-6,5 dan garam empedu 1-6 mL.Kata kunci : Limbah temulawak, Lactobacillus plantarum dan sinbioti

Packaging design as a marketing and branding strategy for Kampar pineapple chips products

Pineapple is a popular crop in the peatlands of Riau province. One of the centers for pineapple production in Riau Province is Kualu Nanas Village, Tambang District, Kampar Regency. Pineapple is processed into chips, one of Riau Province's typical souvenirs. The pineapple chip industry in Kampar Regency faces various obstacles, such as very simple product packaging, short shelf life, varied or negotiable prices, and sub-optimal distribution and marketing. This study aimed to analyze marketing strategies and update the packaging design of pineapple chips to increase sales of pineapple chips. This research uses quantitative descriptive analysis methods (IFE and EFE matrix analysis) and qualitative descriptive analysis (SWOT analysis). Primary data was collected by survey method through interviews and field observations, while secondary data was collected by literature study. The IFE matrix has a score of 2.6165, while the matrix EFE score is 2,5195. One of the results of formulating the pineapple chips marketing strategy is the renewal of the packaging design and improving product marketing through digital marketing

Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function

BACKGROUND: Understanding the genetic architecture of cardiac structure and function may help to prevent and treat heart disease. This investigation sought to identify common genetic variations associated with inter-individual variability in cardiac structure and function. METHODS: A GWAS meta-analysis of echocardiographic traits was performed, including 46,533 individuals from 30 studies (EchoGen consortium). The analysis included 16 traits of left ventricular (LV) structure, and systolic and diastolic function. RESULTS: The discovery analysis included 21 cohorts for structural and systolic function traits (n = 32,212) and 17 cohorts for diastolic function traits (n = 21,852). Replication was performed in 5 cohorts (n = 14,321) and 6 cohorts (n = 16,308), respectively. Besides 5 previously reported loci, the combined meta-analysis identified 10 additional genome-wide significant SNPs: rs12541595 near MTSS1 and rs10774625 in ATXN2 for LV end-diastolic internal dimension; rs806322 near KCNRG, rs4765663 in CACNA1C, rs6702619 near PALMD, rs7127129 in TMEM16A, rs11207426 near FGGY, rs17608766 in GOSR2, and rs17696696 in CFDP1 for aortic root diameter; and rs12440869 in IQCH for Doppler transmitral A-wave peak velocity. Findings were in part validated in other cohorts and in GWAS of related disease traits. The genetic loci showed associations with putative signaling pathways, and with gene expression in whole blood, monocytes, and myocardial tissue. CONCLUSION: The additional genetic loci identified in this large meta-analysis of cardiac structure and function provide insights into the underlying genetic architecture of cardiac structure and warrant follow-up in future functional studies. FUNDING: For detailed information per study, see Acknowledgments.This work was supported by a grant from the US National Heart, Lung, and Blood Institute (N01-HL-25195; R01HL 093328 to RSV), a MAIFOR grant from the University Medical Center Mainz, Germany (to PSW), the Center for Translational Vascular Biology (CTVB) of the Johannes Gutenberg-University of Mainz, and the Federal Ministry of Research and Education, Germany (BMBF 01EO1003 to PSW). This work was also supported by the research project Greifswald Approach to Individualized Medicine (GANI_MED). GANI_MED was funded by the Federal Ministry of Education and Research and the Ministry of Cultural Affairs of the Federal State of Mecklenburg, West Pomerania (contract 03IS2061A). We thank all study participants, and the colleagues and coworkers from all cohorts and sites who were involved in the generation of data or in the analysis. We especially thank Andrew Johnson (FHS) for generation of the gene annotation database used for analysis. We thank the German Center for Cardiovascular Research (DZHK e.V.) for supporting the analysis and publication of this project. RSV is a member of the Scientific Advisory Board of the DZHK. Data on CAD and MI were contributed by CARDIoGRAMplusC4D investigators. See Supplemental Acknowledgments for consortium details. PSW, JFF, AS, AT, TZ, RSV, and MD had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis