Nurturing Agribusiness: A Sustainable Farming System for Tomato Crop Management Leveraging Machine Learning

The agriculture industry is undergoing a transformative shift with the introduction of IoT technology, enabling global connectivity for farmers. This technology offers a plethora of advantages, ranging from precise seed selection based on soil analysis to efficient crop maintenance, water management, and enhanced marketing support for improved profitability. To further enhance tomato farming practices, we propose the implementation of a smart farmer marketing assistant that streamlines the process of segregating yield based on its growth stage, reducing labor and time requirements.Further, the frame work is capable of early-disease management system that can detect  diseases like early blight,light blight, buck eye rot and anthranose and suggest remedy.  By adopting this innovative approach, financial losses associated with traditional methods are minimized.The traditional practice of combining all categories of vegetables (ripened, unripened, and partially rotten) in a single container often results in reduced shelf life for the produce. In our framework, we employ color sorting to categorize the vegetables, ensuring proper packing into their respective bins. This valuable data is made accessible through a cloud environment, providing potential buyers with comprehensive information about the yield, its category, and pricing. This increased visibility empowers farmers to reach a global market and sell their produce at competitive prices. In this context, we present a case study focused on the tomato crop, where we have successfully developed a prototype utilizing ESP32, a color sensor, and Google Firebase. This comprehensive framework effectively harnesses the power of IoT, Machine Learning, and potential marketing strategies, transforming the way farmers manage their crops and connect with buyers on a global scale with highly accurate 87.9% experimental results

Economic analysis of marine fishing crafts in Thoothukudi province, Tamil Nadu

Marine fisheries contribute considerably to the national economy. Fastest growth rate has observed in marine fish production; is attributed equipment modernization in fishing crafts and advancement of fishing technology. Even though, same level of inputs are exerted; there is a discrepancy in their economic performance and efficiency. Therefore, present study was carried out to analyse the inputs use which will give maximum optimal output. The primary data was collected from the 40 respondents from each sector namely mechanized, motorized and traditional, using a pre-tested interview schedule. The stepwise multiple regression approach was performed to find out the most influential variables in each kinds of the fishing crafts. The mechanized crafts have the greater net profit (₹ 9.12 lakhs) and financial performance (58%) than those of the motorized and traditional crafts. The annual fishing days, labour wages and fuel were positively influenced gross revenue of the all the fishing crafts

Vortioxetine, a multimodal antidepressant for generalized anxiety disorder: A systematic review and meta-analysis

Vortioxetine has a beneficial pharmacological profile for reducing anxiety and depression. Recently, a number of randomized, double-blind, placebo-controlled clinical trials (RCTs) of vortioxetine have been conducted in patients with generalized anxiety disorder (GAD); however, the results from GAD RCTs are inconsistent. With an extensive search of databases and clinical trial registries, four published short-term RCTs were identified and included in the present meta-analysis. The mean change in total scores on the Hamilton Anxiety Rating Scale (HAMA) from baseline was the primary endpoint. The secondary endpoints included the response and remission rates, as defined by a ≥50% reduction in HAMA total scores and a ≤7 change in the HAMA total score at the end of treatment. In addition, the mean change in the HAMA total score from baseline in the subgroup with a HAMA total score ≥25 at baseline was included. Vortioxetine was significantly more effective than was placebo, with a standardized mean difference (SMD) of-0.118 (95% CIs,-0.203 to-0.033, P=0.007). In particular, those with severe GAD (HAMA total score ≥25 at baseline) had a significantly greater benefit from vortioxetine than those without (SMD=-0.338, 95% CIs=-0.552 to-0.124, p=0.002). The odds ratios (ORs) for vortioxetine for response and remission were 1.221 (95% CIs, 1.027 to 1.452, P=0.024) and 1.052 (95% CIs, 0.853 to 1.296, P=0.637), respectively. Discontinuation due to adverse events (AEs) (OR=1.560, 1.006 to 2.419, p=0.047) was marginally higher in vortioxetine than placebo treatment, whereas discontinuation due to any reason (OR=0.971, 0.794 to 1.187, p=0.771) and inefficacy (OR=0.687, 0.380 to 1.243, p=0.215) were not significantly different among treatment groups. Although our results suggest that vortioxetine may have a potential as an another treatment option for GAD (especially for severe GAD), they should be interpreted and translated into clinical practice with caution, as the meta-analysis was based on a limited number of RCTs

Vortioxetine: a meta-analysis of 12 short-term, randomized, placebo-controlled clinical trials for the treatment of major depressive disorder

Vortioxetine was approved by the U.S. Food and Drug Administration (FDA) in September 2013 for treating major depressive disorder (MDD). Thus far, a number of randomized, double-blind, placebo-controlled clinical trials (RCTs) of vortioxetine have been conducted in patients with MDD. We performed a meta-analysis to increase the statistical power of these studies and enhance our current understanding of the role of vortioxetine in the treatment of MDD

Cushing's Disease: results of treatment and factors affecting outcome

Objective: To analyze the therapeutic results of intervention and the factors affecting the outcome of patients with Cushing’s Disease (CD) cared for at the All Indian Institute of Medical Science (AIIMS), New Delhi. Design: Patients with Cushing’s Disease treated at a teritiary care centre from January 2000 to December 2009 were prospectively studied. Results: Ninety-seven patients received treatment for CD during this period. Mean duration of follow-up was 3.4 ± 2.2 (mean±SD) years. Eighty-one patients (83.5%) underwent Transsphenoidal Surgery (TSS) as the primary treatment modality. Fifty-four patients (66.7%) went into remission after initial TSS; ten (18.5%) of them relapsed after a mean follow-up period of 2.9±2.1 (mean±SD) years. Histopathologic examination of resected tissue showed corticotroph adenoma in 48 of the 54 (88.9%) who went into remission and 17 of the 27 (63.0%) who did not go into remission after the initial TSS. Sixteen patients with severe hypercortisolism underwent Bilateral Adrenalectomy (BA) as a life-saving measure which was followed by pituitary surgery 6 to 12 months later. Five patients including one with a large macroadenoma required three or more procedures to achieve eucortisolism. Conclusion: Fifty-four out of 81 (66.7%) of our patients with CD had remission following initial TSS, ten of whom relapsed later on. Sixteen patients unerwent BA as a life-saving procedure. Factors affecting outcome were, age, gender, low dose dexamethasone suppression test cortisol value and histologic confirmation of corticotroph adenom