7 research outputs found
A small frontal lobe cavernoma presenting with headache mimicking migraine and complex focal seizure: A case report
Key Clinical Message Cavernoma, or cerebral cavernous angioma, are hamartomatous lesions formed by sinusoidal vascular spaces without cerebral parenchyma in between. Cavernoma is a rare disorder that is diagnosed infrequently and incidentally, so it is called incidentaloma. However, cavernoma can present with seizures, headaches, and other focal neurological deficits, with seizures being the most frequent presentation. Cavernoma is angiographically concealed, and it's diagnosis is challenging. So, the cavernoma is diagnosed based on an MRI. We present the rare case of a patient who presented with a complex focal seizure and migraineâlike headache caused by a small frontal lobe cavernoma
Giant multinodular goiter for 24âyears; hidden in a village in Western Nepal
Abstract Here, we present the case of a giant multinodular goiter with retrosternal extension in an old lady with dyspnea for 3âmonths. The patient was treated with microscopicâassisted total thyroidectomy without any postoperative complications
Snakebite in the Hills and Mountains of Nepal
Snakebite is an important public health issue around the world. In Nepal, it affects a huge number of people mostly belonging to low-income households who are involved in agriculture. Although snakebite has a serious impact on the Terai population, a few studies suggest that snakebite also occurs frequently in hills and mountains. In the absence of sufficient studies related to snakebites in these geographical regions, it is tough to sketch a true picture and estimate the magnitude of snakebites in those areas. Because of this, the healthcare system is probably not prepared enough to handle the victims of snakebites. This demands a proper study of the burden of the issue in these regions and appropriate initiatives for addressing it
2-[(1E,3E)-4-Arylbuta-1,3-dien-1-yl]-4H-chromen-4-ones as dienes in DielsâAlder reactions: experimental and computational studies
The synthesis and reactivity of 2-[(1 ÂŁ,3ÂŁ)-4-arylbuta-1 ,3-dien-l-yl]-4H-chromen-4-ones 1 as
dienes in Diets-Alder (DA) reactions towards several electron-poor and electron-rich
dienophiles under microwave irradiation was studied. The optimized reaction conditions were
achieved by using N-methylmaleimide2 as dienophile and Sc(0Tf)3 as Lewis acid under
microwave-assisted and solvent-free conditions. The Lewis acid improved the reaction yields
since it prevented the adducts obtained to undergo a second DA reaction, thus avoiding
formation of a bisadduct. The a,~:y ,o-diene of the starting chromones showed to be the most
reactive and the computational results confirmed the experimental findings. Theoretical
calculations also allowed explaining some unexpected lack of reactivity by some dienophiles.
The adducts prepared were dehydrogenated by using DDQ, however, the aza-adducts showed
to be sensitive to the high energetic reaction conditions necessary to perform the
aromatization.Thanks are due to University of Aveiro and FCT/MEC for the financial support of the QOPNA research unit (FCT UID/QUI/00062/2013) and CIQ-UP (Pest-C/QUI/UI0081/2013) through national founds and, where applicable, co-financed by the FEDER, within the PT2020 Partnership Agreement, and to the Portuguese NMR Network, as well as to the Instituto Politécnico de Bragança. H.M.T.A. and C.F.R.A.C.L. are grateful to FCT for their PhD (SFRH/BD/86277/2012) and Post-doc (SFRH/BPD/77972/2011) grants,
respectively.info:eu-repo/semantics/publishedVersio