Editorial

Research is the lifeblood of Survival, Sustainability and Success. Over the years research has gained prominence, be it creating a new body of knowledge or analysing socio-economic problems, it has become indispensable. Never before has the environment been so conducive to conduct research. On one side, UGC guidelines make it mandatory for teachers in Higher Education to pursue quality research and on the other side, research funding and support is available in plenty to scholars from various institutions. We are delighted to see some innovative and socially relevant articles embodying the unique thought process and uncanny research capabilities of the researchers. We believe that the readers would certainly notice that the journal carries a variety of genres from the domain of Commerce and Management. The contribution of these researchers to the economy is inestimably precious

Prevalence of unmet need for contraception in urban slum communities, Mumbai

Background: Unmet need for family planning is a tool to monitor the family planning program. Hence, the objective of study is to examine the prevalence of unmet need for family planning among women living in urban slum communities, Mumbai.Methods: The cross-sectional survey was conducted among currently married women aged 18-39 years and having at least one child. A total of 2797 women were selected using systematic random sampling. Information on demographic characteristics, their contraceptive behaviour and fertility intention were collected by face to face interview using structured questionnaire. Chi square test was applied and p <0.05 was considered as significant.  Results: About 59.4% were currently using family planning methods and 40.6% have reported unmet need for family planning. Awareness of contraceptive methods among women with unmet need for family planning was universal. The prevalence of unmet need for family planning significantly decreased as the age and number of children increased. The prevalence of unmet need was significantly higher than met need for family planning among women having one child as compared to women having 2 or more children.Conclusions: A significant gap was observed between met and unmet need for family planning among younger women and having one child. The study emphasises the need for family planning programs to focus on younger couples having one child.

Crystal structure of isobutyl 4-(2-chloro-phenyl)-5-cyano-6-{(E)-[(dimethylamino)-methylidene]amino}-2-methyl-4H-pyran-3-carboxylate

The authors thank Dr Babu Varghese, Senior Scientific Officer SAIF, IIT Madras, India, for carrying out the data collection.Peer reviewedPublisher PD

A COMPARATIVE STUDY ON PHARMACOECONOMIC ANALYSIS OF RHEUMATOID ARTHRITIS PATIENT IN TWO DIFFERENT HOSPITALS IN TAMIL NADU

Objective: The objective of the present study is to compare the prescribing patterns and cost of illness of Rheumatoid arthritis patients in two different hospitals. Methods: This is an observational study conducted in two different tertiary care hospitals in Salem district after obtaining approval of the Institutional Ethics Committee (IEC) (Registration Number EC/PHARM D/2019.06). A sample size of 102 (above 18 y) patients were included (52 from group 1 hospital and 50 from group 2 hospital). The study was conducted over a period of 6 mo from February 2019 to July 2019. The cost was collected by a patient face-to-face interview. Results: Out of 102 patients, females (57.84%) patients were more prevalent than men with the age group of 50-59 y in both groups. Methotrexate was most commonly prescribed drug in group 1(36.5%), whereas in group 2 are Sulfasalazine (37%). Among the DMARDs unit cost of methotrexate is high but the monthly cost was high for Sulfasalazine, because the methotrexate is prescribed on a once-weekly basis while sulfasalazine is taken twice a day. The cost of NSAIDs comes around 46.47% of the total drug cost of the month. In steroids, cost comes around 11.73% of the total drug cost. Among the direct cost of two groups, the drug cost and transportation cost is higher when compared with other costs. Indirect costs such as lost wages, due to disease is higher in group 1. Conclusion: The study concluded that the burden of RA to the patient is huge, Appropriate standard prescribing guidelines should be developed and implementation of the rational drug must be promoted. Polypharmacy was reported in group 1 hospital, the progression of symptoms was the same in both hospitals, it increases the cost of therapy and overall cost of patients. Hence it becomes vital to diagnose and control the disease at an early stage to control the economic burden on the patient

Perception of Community Pharmacist on self-medication in Erode, India

ABSTRACT The aim of this study was to explore the perceptions of community pharmacists towards the concept of self-medication Erode, India. A cross-sectional study was carried out in Erode between august2010and December, 2010. A 20-item self-completion questionnaire was administered to randomly selected sample of 50 community pharmacists from Erode. Main outcome measures included understanding of self-medication, reasons for why patients practice self-medication, source for drug of choice, attitude towards Patient counseling, barriers to implementation of patient counseling. Data&apos;s were analyzed. Descriptive results were expressed as frequency and percentage. Most patients were seeking self medication for headache 14.72%, Fever 14.29%, urinary tract infections 10.13% etc. The drugs most commonly dispensed or purchased on a self medication basis were NSAIDS 33.7%. Pharmacists 56% and previous prescription 24% were the common sources from where patients get information about drug of choice. Simplicity of the disease 44% was the reason why patients prefer selfmedication. Lack of time 60% and lack of interest of the patients 36% were the reasons that pharmacists mentioned for not counselling the patients. Main reason for practicing self-medication irrational self-medication is due to their lack of knowledge about the complications that can occur by practicing self-medication without proper diagnosis. These barriers could be overcome through participation in effective continuing educational programs and creating awareness to the public about the complication of self-medication without proper diagnosis. Patient health awareness programs and pharmacist continuing education are necessary in Erode

Comparative Evaluation of Various Statistical Models and Its Accuracy for Landslide Risk Mapping: A Case Study on Part of Himalayan Region, India

Among other natural hazards, Landslides are the most prominent and frequently occurring natural disaster in the state of Himachal Pradesh with higher socio-economical losses. About 0.42 million sq.kms of area are prone to landslide activities in our country that is excluding the snow covered areas. The current research focuses on estimating the landslide risk zones of the Shimla Tehsil, Himachal Pradesh using various statistical models. Landslide contributing factors as such Landuse Landcover, Elevation, Slope, Lithology, Soil, Geology and Geomorphology has been used to assess the Landslide risk factors. Data obtained from LANDSAT 8 OLI sensors, SRTM DEM, Soil and Land Use Survey of India and SOI Toposheets have been used as sources. Weighted Overlay, Fuzzy logic and Analytical Hierarchical Process models will be used to categorize the Vulnerability and risk Zones of the study area. The causative factors were analyzed and processed in GIS environment. These values will be then being integrated using various studied models to produce individual landslide vulnerability and risk zones. The results reveal that most of the study area falls under Very Low risk category with a total coverage of 67.34%. Low and Moderate area covers about 23% and 9.13% of the study area. Higher risk areas only account for about 0.46%. Higher percent of the study area is mostly covered by settlements. National highways, Metal roads, Slopes and Denser settlements are located along the Moderate and low risk areas. The results retrieved from the WOM model reveals a total of 55% of the area comes under very low category. Low and Moderate category covers about 31.4% and 10.6% of the study area. High and Very High category cover a total of 1.9% together

Topologically non-trivial metal-organic assemblies inhibit \u3b22-microglobulin amyloidogenesis

Inhibiting amyloid aggregation through high-turnover dynamic interactions could be an efficient strategy that is already used by small heat-shock proteins in different biological contexts. We report the interactions of three topologically non-trivial, zinc-templated metal-organic assemblies, a [2]catenane, a trefoil knot (TK), and Borromean rings, with two \u3b22-microglobulin (\u3b22m) variants responsible for amyloidotic pathologies. Fast exchange and similar patterns of preferred contact surface are observed by NMR, consistent with molecular dynamics simulations. In vitro fibrillation is inhibited by each complex, whereas the zinc-free TK induces protein aggregation and does not inhibit fibrillogenesis. The metal coordination imposes structural rigidity that determines the contact area on the \u3b22m surface depending on the complex dimensions, ensuring in vitro prevention of fibrillogenesis. Administration of TK, the best protein-contacting species, to a disease-model organism, namely a Caenorhabditis elegans mutant expressing the D76N \u3b22m variant, confirms the bioactivity potential of the knot topology and suggests new developments

Ion-Mobility Mass Spectrometry for the Rapid Determination of the Topology of Interlocked and Knotted Molecules.

A rapid screening method based on traveling-wave ion-mobility spectrometry (TWIMS) combined with tandem mass spectrometry provides insight into the topology of interlocked and knotted molecules, even when they exist in complex mixtures, such as interconverting dynamic combinatorial libraries. A TWIMS characterization of structure-indicative fragments generated by collision-induced dissociation (CID) together with a floppiness parameter defined based on parent- and fragment-ion arrival times provide a straightforward topology identification. To demonstrate its broad applicability, this approach is applied here to six Hopf and two Solomon links, a trefoil knot, and a [3]catenate.Deutsche Forschungsgemeinschaft (CRC 765 “Multivalency”). Alexander von Humboldt Foundation. Swiss National Science Foundation (PZ00P2_161270). Fondation Wiener-Anspach

Photoelectric Properties of Silicon Nanocrystals/P3HT Bulk-Heterojunction Ordered in Titanium Dioxide Nanotube Arrays

A silicon nanocrystals (Si-ncs) conjugated-polymer-based bulk-heterojunction represents a promising approach for low-cost hybrid solar cells. In this contribution, the bulk-heterojunction is based on Si-ncs prepared by electrochemical etching and poly(3-hexylthiophene) (P3HT) polymer. Photoelectric properties in parallel and vertical device-like configuration were investigated. Electronic interaction between the polymer and surfactant-free Si-ncs is achieved. Temperature-dependent photoluminescence and transport properties were studied and the ratio between the photo- and dark-conductivity of 1.7 was achieved at ambient conditions. Furthermore the porous titanium dioxide (TiO2) nanotubes’ template was used for vertical order of photosensitive Si-ncs/P3HT-based blend. The anodization of titanium foil in ethylene glycol-based electrolyte containing fluoride ions and subsequent thermal annealing were used to prepare anatase TiO2nanotube arrays. The arrays with nanotube inner diameter of 90 and 50 nm were used for vertical ordering of the Si-ncs/P3HT bulk-heterojunction

Synthesis, Characterization and Thermal Studies of Zn(II), Cd(II) and Hg(II) Complexes of N-Methyl-N-Phenyldithiocarbamate: The Single Crystal Structure of [(C6H5)(CH3)NCS2]4Hg2

Zn(II), Cd(II) and Hg(II) complexes of N-methyl-N-phenyl dithiocarbamate have been synthesized and characterized by elemental analysis and spectral studies (IR, 1H and 13C-NMR). The single crystal X-ray structure of the mercury complex revealed that the complex contains a Hg centre with a distorted tetrahedral coordination sphere in which the dinuclear Hg complex resides on a crystallographic inversion centre and each Hg atom is coordinated to four S atoms from the dithiocarbamate moiety. One dithiocarbamate ligand acts as chelating ligand while the other acts as chelating bridging ligand between two Hg atoms, resulting in a dinuclear eight-member ring. The course of the thermal degradation of the complexes has been investigated using thermogravimetric and differential thermal analyses techniques. Thermogravimetric analysis of the complexes show a single weight loss to give MS (M = Zn, Cd, Hg) indicating that they might be useful as single source precursors for the synthesis of MS nanoparticles and thin films