El Tipo de Cambio Real de Costa Rica

This paper estimates Costa Rica’s Equilibrium Real Exchange Rate (ERER) using quarterly data from 1991 to 2003. Cointegration and Unit Root tests are used to determine if the Purchasing Power Parity (PPP) applies. The results show that PPP does not stand. The ERER is an unobservable variable; therefore it is approximate by two methods developed in the literature: BEER (Behavioral Equilibrium Exchange Rate) which explains the deviations from PPP as a result of changes in the fundamentals; and FEER (Fundamental Equilibrium Exchange Rate) that estimates the long run equilibrium path of the real exchange rate under a partial equilibrium structural model. Both methods show a real appreciation in the 90s until 2001 and a real undervaluation of the colón for 2003

El Tipo de Cambio Real de Costa Rica

This paper estimates Costa Rica’s Equilibrium Real Exchange Rate (ERER) using quarterly data from 1991 to 2003. Cointegration and Unit Root tests are used to determine if the Purchasing Power Parity (PPP) applies. The results show that PPP does not stand. The ERER is an unobservable variable; therefore it is approximate by two methods developed in the literature: BEER (Behavioral Equilibrium Exchange Rate) which explains the deviations from PPP as a result of changes in the fundamentals; and FEER (Fundamental Equilibrium Exchange Rate) that estimates the long run equilibrium path of the real exchange rate under a partial equilibrium structural model. Both methods show a real appreciation in the 90s until 2001 and a real undervaluation of the colón for 2003

Diagnosability in Switched Linear Systems

Non

Diseño y elaboración de un sistema de información para perfiles estadísticos de pacientes con diabetes e hipertensión. caso clínicas de la ciudad de Guayaquil

El presente trabajo desarrolla un sistema de información cuyo objetivo principal es servir de herramienta a los médicos, pacientes y administradores de las clínicas de Guayaquil para obtener información actualizada mediante la presentación de perfiles estadísticos, basados en la información de las historias clínicas registradas en una base de datos, se convertirá en un aliado importantes al momento de tomar decisiones, ya sea en el área administrativa o en el área médica

Evaluación de la cadena de suministros para optimizar la gestión del almacén de la empresa Las Patitas en la ciudad de Cajamarca, 2022

La cadena de suministros y su elemento la gestión del almacén, son partes primordiales en toda empresa, razón por la cual se han estudiado en dicha investigación, para ello, se realizó un estudio general de ambos, donde se concluyó lo siguiente, primero, la empresa no presentó un correcto control de los productos del almacén, segundo no tiene el suficiente espacio para el mismo, y tercero, los productos no se encontraban clasificados y menos en el orden establecido. La presente investigación tuvo como objetivo general evaluar la Cadena de Suministros para optimizar la Gestión de Almacén de la empresa “Las Patitas” en la ciudad de Cajamarca. El tipo de diseño de la investigación es Pre-Experimental y aplicada cuantitativa. La población y la muestra están conformadas por el área de almacén de la empresa de los meses de abril a agosto del año 2022. Las técnicas fueron la observación y análisis documental. Con ello, el plan de capacitación ayudó a que los trabajadores se hayan involucrado en un 70% más, por otra parte, la implementación de las 5`S aumentó más la optimización del almacén en un 80%, aprovechando el espacio, manteniendo un orden y limpieza, logrando así el objetivo principal. Y finalmente la implementación del Kárdex mejoró en un 90% todo el control de los objetos que han ingresado y salido del almacén, indicando así cuando se hará los pedidos contribuyendo al proceso de abastecimiento

A real-life study of the effectiveness of different pharmacological approaches to the treatment of smoking cessation: re-discussing the predictors of success

OBJECTIVE: To evaluate the effectiveness of nicotine replacement therapy (NRT), bupropion, nortriptyline and combination therapy and describe factors associated with treatment success. INTRODUCTION: Clinical trials clearly demonstrate the efficacy of pharmacotherapy in smoking cessation. However, it is only after its use in real-life settings that clinical effectiveness and limitations of a treatment are fully known. METHODS: Patients attended a four-session cognitive-behavioral program and received medicines free of charge. Abstinence from smoking was assessed at each visit. RESULTS: A total of 868 smokers (68.8% women) were included. Their mean age was 49.6 years; the amount smoked was 25 cigarettes/day and the Fagerströ m Score was 6.6. Abstinence rates after 6 months and 1 year were 36.5% and 33.6%. In univariate analysis, male gender, age (>;50), higher number of cigarettes smoked, cardiovascular comorbidities, longer interval from the last cigarette and combined treatment of nortriptyline plus NRT were predictive of abstinence, while neuropsychiatric comorbidities and the answer ''yes'' to the question ''Do you smoke more often during the first hours after waking'' were correlated with failure. In a multivariate model, predictors of abstinence were neuropsychiatric comorbidities, the answer ''yes'' to the question ''Do you smoke more often during the first hours after waking'' and combined treatment of nortriptyline plus NRT. Male gender and a longer period from the last cigarette were correlated with lower abstinence rate. CONCLUSION: Satisfactory success rates were obtained in a teaching hospital. Factors such as age, daily cigarette consumption, number of pack-years and dependency score were not reliable markers of abstinence. The combination nortriptyline+NRT was independently associated with higher abstinence rates

A real‐life study of the effectiveness of different pharmacological approaches to the treatment of smoking cessation: re‐discussing the predictors of success

OBJECTIVE: To evaluate the effectiveness of nicotine replacement therapy (NRT), bupropion, nortriptyline and combination therapy and describe factors associated with treatment success. INTRODUCTION: Clinical trials clearly demonstrate the efficacy of pharmacotherapy in smoking cessation. However, it is only after its use in real-life settings that clinical effectiveness and limitations of a treatment are fully known. METHODS: Patients attended a four-session cognitive-behavioral program and received medicines free of charge. Abstinence from smoking was assessed at each visit. RESULTS: A total of 868 smokers (68.8% women) were included. Their mean age was 49.6 years; the amount smoked was 25 cigarettes/day and the Fagerströ m Score was 6.6. Abstinence rates after 6 months and 1 year were 36.5% and 33.6%. In univariate analysis, male gender, age (>50), higher number of cigarettes smoked, cardiovascular comorbidities, longer interval from the last cigarette and combined treatment of nortriptyline plus NRT were predictive of abstinence, while neuropsychiatric comorbidities and the answer ''yes'' to the question ''Do you smoke more often during the first hours after waking'' were correlated with failure. In a multivariate model, predictors of abstinence were neuropsychiatric comorbidities, the answer ''yes'' to the question ''Do you smoke more often during the first hours after waking'' and combined treatment of nortriptyline plus NRT. Male gender and a longer period from the last cigarette were correlated with lower abstinence rate. CONCLUSION: Satisfactory success rates were obtained in a teaching hospital. Factors such as age, daily cigarette consumption, number of pack-years and dependency score were not reliable markers of abstinence. The combination nortriptyline+NRT was independently associated with higher abstinence rates

Plan de negocios centro deportivo de pádel en Surco, Lima, Perú

En Lima Metropolitana, se ha quintuplicado la cantidad de jugadores de pádel y se ha cuadruplicado el número de canchas de pádel disponibles para alquiler en apenas dos años. La creciente popularidad del deporte pádel en la ciudad y su limitada infraestructura actual para practicarlo representan una oportunidad de negocio interesante para irrumpir en este mercado. Debido a ello, surge Pádel PE, un centro deportivo especializado en pádel ubicado en el distrito de Santiago de Surco, con un servicio diferenciado y con una infraestructura integral y complementaria que tiene tres pilares fundamentales: la generación de comunidad, la digitalización y el enfoque centrado en el cliente. Contará con seis canchas panorámicas de pádel, los mejores profesores y clases de pádel a nivel nacional, un bar y un restaurante, un gimnasio, una tienda de equipamiento y accesorios de las marcas más populares a nivel mundial de pádel, y estacionamientos gratuitos

In silico Analyses of Immune System Protein Interactome Network, Single-Cell RNA Sequencing of Human Tissues, and Artificial Neural Networks Reveal Potential Therapeutic Targets for Drug Repurposing Against COVID-19

Background: There is pressing urgency to identify therapeutic targets and drugs that allow treating COVID-19 patients effectively.Methods: We performed in silico analyses of immune system protein interactome network, single-cell RNA sequencing of human tissues, and artificial neural networks to reveal potential therapeutic targets for drug repurposing against COVID-19.Results: We screened 1,584 high-confidence immune system proteins in ACE2 and TMPRSS2 co-expressing cells, finding 25 potential therapeutic targets significantly overexpressed in nasal goblet secretory cells, lung type II pneumocytes, and ileal absorptive enterocytes of patients with several immunopathologies. Then, we performed fully connected deep neural networks to find the best multitask classification model to predict the activity of 10,672 drugs, obtaining several approved drugs, compounds under investigation, and experimental compounds with the highest area under the receiver operating characteristics.Conclusion: After being effectively analyzed in clinical trials, these drugs can be considered for treatment of severe COVID-19 patients. Scripts can be downloaded at