Beyond operator-precedence grammars and languages

Operator Precedence Languages (OPL) are deterministic context-free and have desirable properties. OPL are parallely parsable, and, when structurally compatible, are closed under Boolean operations, concatenation and star; they include the Input Driven languages. OPL use three relations between two terminal symbols, to assign syntax structure to words. We extend such relations to k-tuples of consecutive symbols, in agreement with strictly locally testable regular languages. For each k, the new corresponding class of Higher-order Operator Precedence languages properly includes the OPL and enjoy many of their properties. OPL are a strict hierarchy based on k, which contains maximal languages

APERIODICITY, STAR-FREENESS, AND FIRST-ORDER LOGIC DEFINABILITY OF OPERATOR PRECEDENCE LANGUAGES

A classic result in formal language theory is the equivalence among non-counting, or aperiodic, regular languages, and languages defined through star-free regular expressions, or first-order logic. Past attempts to extend this result beyond the realm of regular languages have met with difficulties: for instance it is known that star-free tree languages may violate the non-counting property and there are aperiodic tree languages that cannot be defined through first-order logic. We extend such classic equivalence results to a significant family of deterministic context-free languages, the operator-precedence languages (OPL), which strictly includes the widely investigated visibly pushdown, alias input-driven, family and other structured context-free languages. The OP model originated in the ’60s for defining programming languages and is still used by high performance compilers; its rich algebraic properties have been investigated initially in connection with grammar learning and recently completed with further closure properties and with monadic second order logic definition. We introduce an extension of regular expressions, the OP-expressions (OPE) which define the OPLs and, under the star-free hypothesis, define first-order definable and non-counting OPLs. Then, we prove, through a fairly articulated grammar transformation, that aperiodic OPLs are first-order definable. Thus, the classic equivalence of star-freeness, aperiodicity, and first-order definability is established for the large and powerful class of OPLs. We argue that the same approach can be exploited to obtain analogous results for visibly pushdown languages too

Gastrointestinal neuroendocrine neoplasms (GI-NENs): hot topics in morphological, functional, and prognostic imaging

Neuroendocrine neoplasms (NENs) are heterogeneous tumours with a common phenotype descended from the diffuse endocrine system. NENs are found nearly anywhere in the body but the most frequent location is the gastrointestinal tract. Gastrointestinal neuroendocrine neoplasms (GI-NENs) are rather uncommon, representing around 2% of all gastrointestinal tumours and 20–30% of all primary neoplasms of the small bowel. GI-NENs have various clinical manifestations due to the different substances they can produce; some of these tumours appear to be associated with familial syndromes, such as multiple endocrine neoplasm and neurofibromatosis type 1. The current WHO classification (2019) divides NENs into three major categories: well-differentiated NENs, poorly differentiated NENs, and mixed neuroendocrine-non-neuroendocrine neoplasms. The diagnosis, localization, and staging of GI-NENs include morphology and functional imaging, above all contrast-enhanced computed tomography (CECT), and in the field of nuclear medicine imaging, a key role is played by (68)Ga-labelled-somatostatin analogues ((68)Ga-DOTA-peptides) positron emission tomography/computed tomography (PET/TC). In this review of recent literature, we described the objectives of morphological/functional imaging and potential future possibilities of prognostic imaging in the assessment of GI-NENs

A novel scytalidium species : understand the cellulolytic system for biomass saccharification

In order to overcome the bottlenecks related to lignocellulosic-derived sugars, the search for more efficient enzymatic cocktails, containing a broad-spectrum of specific activities, relies on an important feature. This paper describes new enzyme activities derived from the novel strain of the Scytalidium genus isolated from the Amazonas rainforest. The production of the enzymatic cocktail was induced by delignifiedhydrothermal bagasse (DHB), and yeast extract was used to improve secretion activities, resulting in a positive influence on total cellulase activity. The enzymatic cocktail produced by this novel strain contains specific activities for biomass degradation, including FPAse, xylanase and β-glucosidase. Moreover, it is capable of hydrolyzing 62% of the alkaline pretreated bagasse, surpassing in 14% the hydrolytic capability achieved by the commercial cocktail Celluclast. To this extent, the strain described here emerges as a reliable alternative to other available enzymes and, consequently, amplification of available specific substrate activities3618597FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP2010/51309-

A novel deleterious PTEN mutation in a patient with early-onset bilateral breast cancer.

Background An early age at Breast Cancer (BC) onset may be a hallmark of inherited predisposition, but BRCA1/2 mutations are only found in a minority of younger BC patients. Among the others, a fraction may carry mutations in rarer BC genes, such as TP53, STK11, CDH1 and PTEN. As the identification of women harboring such mutations allows for targeted risk-management, the knowledge of associated manifestations and an accurate clinical and family history evaluation are warranted. Case presentation We describe the case of a woman who developed an infiltrating ductal carcinoma of the right breast at the age of 32, a contralateral BC at age 36 and another BC of the right breast at 40. When she was 39 years-old, during a dermatological examination, mucocutaneous features suggestive of Cowden Syndrome, a disorder associated to germ-line PTEN mutations, were noticed. PTEN genetic testing revealed the novel c.71A > T (p.Asp24Val) mutation, whose deleterious effect, suggested by conservation data and in silico tools, was definitely demonstrated by the incapacity of mutant PTEN to inhibit Akt phosphorylation when used to complement PTEN-null cells. In BC tissue, despite the absence of LOH or somatic mutations of PTEN, Akt phosphorylation was markedly increased in comparison to normal tissue, thus implying additional somatic events into the deregulation of the PI3K/Akt/mTOR pathway and, presumably, into carcinogenesis. Hence, known oncogenic mutations in PIK3CA (exons 10 and 21) and AKT1 (exon 2) were screened in tumor DNA with negative results, which suggests that the responsible somatic event(s) is a different, uncommon one. Conclusion This case stresses the importance of clinical/genetic assessment of early-onset BC patients in order to identify mutation carriers, who are at high risk of new events, so requiring tailored management. Moreover, it revealed a novel PTEN mutation with pathogenic effect, pointing out, however, the need for further efforts to elucidate the molecular steps of PTEN-associated carcinogenesis

Ultrasound-guided percutaneous irrigation of calcific tendinopathy: Technical developments

Rotator cuff calcific tendinopathy (RCCT) is a common and painful shoulder disease character-ised by deposition of calcium into the rotator cuff’s tendond. Different therapeutic options have been proposed, but the ultrasound-guided percutaneous irrigation (US-PICT) is been proved as an effective and safe first-line treatment. It can be performed with a single-of a double-needle tecnique, using warm saline solution to improve the dissolution of the calcific deposit. The procedure is ended with an intrabursal injection of local anaesthetics and slow-release steroids to improve the pain relief and to prevent complications. US-PICT leads to significative improvement in the shoulder funtion and pain relief in the short and long term, with a low complications rate. (www.actabiomedica.it)

Eicosapentaenoic acid (EPA) production in silico by Pythium irregulare, as value-added product, using sugarcane vinasse as carbon source

info:eu-repo/semantics/publishedVersio