Time for global action: an optimised cooperative approach towards effective climate change mitigation

The difficulties in climate change negotiations together with the recent withdrawal of the U.S. from the Paris Agreement call for new cooperative mechanisms to enable a resilient international response. In this study we propose an approach to aid such negotiations based on quantifying the benefits of interregional cooperation and distributing them among the participants in a fair manner. Our approach is underpinned by advanced optimisation techniques that automate the screening of millions of alternatives for differing levels of cooperation, ultimately identifying the most cost-effective solutions for meeting emission targets. We apply this approach to the Clean Power Plan, a related act in the U.S. aiming at curbing carbon emissions from electricity generation, but also being withdrawn. We find that, with only half of the states cooperating, the cost of electricity generation could be reduced by US$41 billion per year, while simultaneously cutting carbon emissions by 68% below 2012 levels. These win–win scenarios are attained by sharing the emission targets and trading electricity among the states, which allows exploiting regional advantages. Fair sharing of dividends may be used as a key driver to spur cooperation since the global action to mitigate climate change becomes beneficial for all participants. Even if global cooperation remains elusive, it is worth trying since the mere cooperation of a few states leads to significant benefits for both the U.S. economy and the climate. These findings call on the U.S. to reconsider its withdrawal but also boost individual states to take initiative even in the absence of federal action

Predicting Forage Intake by Sheep through the Pampa Corte Model or NRC

The aim of the present study was to evaluate the precision and accuracy of the Pampa Corte and National Research Council (2007; NRC) models for predicting forage intake (FI) by sheep. Individual data (n = 213) of observed FI, body weight and chemical composition of consumed diet were taken from fifteen indoor digestibility trials conducted with male sheep housed in metabolic cages and fed only forage ad libitum. The diets were composed of tropical grasses, temperate grasses and legumes. Individual observations of FI were averaged by treatment (n = 32) into each experiment which were then compared to FI values predicted by Pampa Corte model or NRC using concordance correlation coefficient (CCC) and regression analysis. The average value of observed FI was 847 (± 241) whereas those predicted by Pampa Corte model and NRC were, respectively, 826 (± 230) and 987 (± 208) g DM/day. Observed values of FI were linearly related (P \u3c 0.01) to those predicted through either Pampa Corte or NRC. However, the Pampa Corte resulted in higher CCC than NRC. Also, through the Pampa Corte model, the linear regression presented a slope not different from 1 and an intercept not different from 0. The NRC model, however, resulted in a slope of the linear regression lower than 1 despite the intercept was not different from 0. The Pampa Corte model was more precise and accurate in predicting FI by sheep fed only forage than NRC

Influence of conservation tillage and soil water content on crop yield in dryland compacted alfisol of Central Chile

Chilean dryland areas of the Mediterranean climate region are characterized by highly degraded and compacted soils, which require the use of conservation tillage systems to mitigate water erosion as well as to improve soil water storage. An oat (Avena sativa L. cv. Supernova-INIA) - wheat (Triticum aestivum L. cv. Pandora-INIA) crop rotation was established under the following conservation systems: no tillage (Nt), Nt + contour plowing (Nt+Cp), Nt + barrier hedge (Nt+Bh), and Nt + subsoiling (Nt+Sb), compared to conventional tillage (Ct) to evaluate their influence on soil water content (SWC) in the profile (10 to 110 cm depth), the soil compaction and their interaction with the crop yield. Experimental plots were established in 2007 and lasted 3 yr till 2009 in a compacted Alfisol. At the end of the growing seasons, SWC was reduced by 44 to 51% in conservation tillage systems and 60% in Ct. Soil water content had a significant (p < 0.05) interaction with tillage system and depth; Nt+Sb showed lower SWC between 10 to 30 cm, but higher and similar to the rest between 50 to 110 cm except for Ct. Although, SWC was higher in conservation tillage systems, the high values on soil compaction affected yield. No tillage + subsoiling reduced soil compaction and had a significant increment of grain yield (similar to Ct in seasons 2008 and 2009). These findings show us that the choice of conservation tillage in compacted soils of the Mediterranean region needs to improve soil structure to obtain higher yields and increment SWC

Sex-Specific Microglial Responses to Glucocerebrosidase Inhibition: Relevance to GBA1-Linked Parkinson’s Disease

Microglia are heterogenous cells characterized by distinct populations each contributing to specific biological processes in the nervous system, including neuroprotection. To elucidate the impact of sex-specific microglia heterogenicity to the susceptibility of neuronal stress, we video-recorded with time-lapse microscopy the changes in shape and motility occurring in primary cells derived from mice of both sexes in response to pro-inflammatory or neurotoxic stimulations. With this morpho-functional analysis, we documented distinct microglia subpopulations eliciting sex-specific responses to stimulation: male microglia tended to have a more pro-inflammatory phenotype, while female microglia showed increased sensitivity to conduritol-B-epoxide (CBE), a small molecule inhibitor of glucocerebrosidase, the enzyme encoded by the GBA1 gene, mutations of which are the major risk factor for Parkinson’s Disease (PD). Interestingly, glucocerebrosidase inhibition particularly impaired the ability of female microglia to enhance the Nrf2-dependent detoxification pathway in neurons, attenuating the sex differences observed in this neuroprotective function. This finding is consistent with the clinical impact of GBA1 mutations, in which the 1.5–2-fold reduced risk of developing idiopathic PD observed in female individuals is lost in the GBA1 carrier population, thus suggesting a sex-specific role for microglia in the etiopathogenesis of PD-GBA1

A fast and long-lived outflow from the supermassive black hole in NGC 5548

Supermassive black holes in the nuclei of active galaxies expel large amounts of matter through powerful winds of ionized gas. The archetypal active galaxy NGC 5548 has been studied for decades, and high-resolution X-ray and UV observations have previously shown a persistent ionized outflow. An observing campaign in 2013 with six space observatories shows the nucleus to be obscured by a long-lasting, clumpy stream of ionized gas never seen before. It blocks 90% of the soft X-ray emission and causes simultaneous deep, broad UV absorption troughs. The outflow velocities of this gas are up to five times faster than those in the persistent outflow, and at a distance of only a few light days from the nucleus, it may likely originate from the accretion disk.Comment: 25 pages, 8 figures. This is the author's version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science, electronically available at Science Express (June 19, 2014). For a brief video explaining the key results of this paper, please visit http://www.issibern.ch/teams/ngc5548/?page_id=2

HAG1 and SWI3A/B control of male germ line development in P. patens suggests conservation of epigenetic reproductive control across land plants

Bryophytes as models to study the male germ line: loss-of-function mutants of epigenetic regulators HAG1 and SWI3a/b demonstrate conserved function in sexual reproduction

Anatomy of the AGN in NGC 5548: I. A global model for the broadband spectral energy distribution

An extensive multi-satellite campaign on NGC 5548 has revealed this archetypal Seyfert-1 galaxy to be in an exceptional state of persistent heavy absorption. Our observations taken in 2013-2014 with XMM-Newton, Swift, NuSTAR, INTEGRAL, Chandra, HST and two ground-based observatories have together enabled us to establish that this unexpected phenomenon is caused by an outflowing stream of weakly ionised gas (called the obscurer), extending from the vicinity of the accretion disk to the broad-line region. In this work we present the details of our campaign and the data obtained by all the observatories. We determine the spectral energy distribution of NGC 5548 from near-infrared to hard X-rays by establishing the contribution of various emission and absorption processes taking place along our line of sight towards the central engine. We thus uncover the intrinsic emission and produce a broadband continuum model for both obscured (average summer 2013 data) and unobscured ($<$ 2011) epochs of NGC 5548. Our results suggest that the intrinsic NIR/optical/UV continuum is a single Comptonised component with its higher energy tail creating the 'soft X-ray excess'. This component is compatible with emission from a warm, optically-thick corona as part of the inner accretion disk. We then investigate the effects of the continuum on the ionisation balance and thermal stability of photoionised gas for unobscured and obscured epochs.Comment: Accepted for publication in A&A, 19 pages, 13 figure