Shape-Morphing Polymers for Tunable Frequency Selective Surfaces and Reflectarray Elements

This is the author accepted manuscript. The final version is available from IEEE via the DOI in this recordThis work presents a route to rapidly configuring electromagnetic metamaterials and elements such as reflectarrays from a generic ‘blank’. The concept is based upon the thermal-shrinkage properties of prestrained polystyrene (PPS), which is utilized in two distinct designs: In the first, an array of resonant split rings is printed upon a sheet of PPS. It is shown that heating to near the glass transition temperature of the sheet can controllably shrink the entire structure, thereby tuning its spectral transmission or reflection. A second application is to make coupled resonant elements, one of which is placed on a hinge of PPS that can be deformed via optical illumination, providing an optical route to tuning the resonance. This kind of element can show a large range of phase shifts in the reflected radiation, and opens the door to the creation of optically configurable reflectarrays.Engineering and Physical Sciences Research Council (EPSRC)Royal Academy of Engineering (RAE

Multiband superbackscattering via mode superposition in a single dielectric particle

This is the accepted manuscript. The final published version is available from American Institute of Physics via the DOI in this record.The superposition of resonances in a subwavelength particle can be used to achieve powerful scattering beyond the single channel limit and can also determine the directionality of scattered radiation. It has been proposed that by overlapping modes only with equivalent polarity in the far-field, a “superbackscattering” condition, where the total backscattered power is maximized, can be achieved. This effect can be observed through the simple geometry of a high permittivity, subwavelength sphere with a hollow core, and we demonstrate this experimentally by comparing the radar cross section (RCS) of such structures, attaining a doubling of the RCS compared to a solid particle. Furthermore, we show that several sets of modes can be overlapped at once, leading to a multiband, superbackscattering effect.Royal Academy of Engineering (RAE)Engineering and Physical Sciences Research Council (EPSRC

Superscattering and Directive Antennas via Mode Superposition in Subwavelength Core-Shell Meta-Atoms

This is the final version. Available on open access from MDPI via the DOI in this recordData Availability Statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.Designing a subwavelength structure with multiple degenerate resonances at the same frequency can vastly enhance its interaction with electromagnetic radiation, as well as define its directivity. In this work we demonstrate that such mode superposition or ‘stacking’ can be readily achieved through the careful structuring of a high-permittivity spherical shell, with either a metallic or a low permittivity dielectric (air) core. We examine the behaviour of these structures both as scatterers of plane wave radiation and as directive antennas. In the case where the core is metallic this leads to a superposition of the magnetic and electric modes of the same order, causing suppression of backscattering and unidirectional antenna emission. For an air core, an electric mode can superimpose with the next-highest order magnetic mode, the backscattered power is maximized and antenna emission is bidirectional. This is shown experimentally at microwave frequencies by observing the backscattering of core-shell spheres and we propose two antenna designs demonstrating different emission patterns defined by the superposition of multiple modes.Royal Academy of Engineering (RAE)Engineering and Physical Sciences Research Council (EPSRC

Memory reorganization following anterior temporal lobe resection: a longitudinal functional MRI study

Anterior temporal lobe resection controls seizures in 50-60% of patients with intractable temporal lobe epilepsy but may impair memory function, typically verbal memory following left, and visual memory following right anterior temporal lobe resection. Functional reorganization can occur within the ipsilateral and contralateral hemispheres. We investigated the reorganization of memory function in patients with temporal lobe epilepsy before and after left or right anterior temporal lobe resection and the efficiency of postoperative memory networks. We studied 46 patients with unilateral medial temporal lobe epilepsy (25/26 left hippocampal sclerosis, 16/20 right hippocampal sclerosis) before and after anterior temporal lobe resection on a 3 T General Electric magnetic resonance imaging scanner. All subjects had neuropsychological testing and performed a functional magnetic resonance imaging memory encoding paradigm for words, pictures and faces, testing verbal and visual memory in a single scanning session, preoperatively and again 4 months after surgery. Event-related analysis revealed that patients with left temporal lobe epilepsy had greater activation in the left posterior medial temporal lobe when successfully encoding words postoperatively than preoperatively. Greater pre- than postoperative activation in the ipsilateral posterior medial temporal lobe for encoding words correlated with better verbal memory outcome after left anterior temporal lobe resection. In contrast, greater postoperative than preoperative activation in the ipsilateral posterior medial temporal lobe correlated with worse postoperative verbal memory performance. These postoperative effects were not observed for visual memory function after right anterior temporal lobe resection. Our findings provide evidence for effective preoperative reorganization of verbal memory function to the ipsilateral posterior medial temporal lobe due to the underlying disease, suggesting that it is the capacity of the posterior remnant of the ipsilateral hippocampus rather than the functional reserve of the contralateral hippocampus that is important for maintaining verbal memory function after anterior temporal lobe resection. Early postoperative reorganization to ipsilateral posterior or contralateral medial temporal lobe structures does not underpin better performance. Additionally our results suggest that visual memory function in right temporal lobe epilepsy is affected differently by right anterior temporal lobe resection than verbal memory in left temporal lobe epilepsy

Role for the thromboxane A 2 receptor β-isoform in the pathogenesis of intrauterine growth restriction

Intrauterine growth restriction (IUGR) is a pathology of pregnancy that results in failure of the fetus to reach its genetically determined growth potential. In developed nations the most common cause of IUGR is impaired placentation resulting from poor trophoblast function, which reduces blood flow to the fetoplacental unit, promotes hypoxia and enhances production of bioactive lipids (TXA 2 and isoprostanes) which act through the thromboxane receptor (TP). TP activation has been implicated as a pathogenic factor in pregnancy complications, including IUGR; however, the role of TP isoforms during pregnancy is poorly defined. We have determined that expression of the human-specific isoform of TP (TPβ) is increased in placentae from IUGR pregnancies, compared to healthy pregnancies. Overexpression of TPα enhanced trophoblast proliferation and syncytialisation. Conversely, TPβ attenuated these functions and inhibited migration. Expression of the TPβ transgene in mice resulted in growth restricted pups and placentae with poor syncytialisation and diminished growth characteristics. Together our data indicate that expression of TPα mediates normal placentation; however, TPβ impairs placentation, and promotes the development of IUGR, and represents an underappreciated pathogenic factor in humans

Demonstration and Control of “Spoof-Plasmon” Scattering from 3D Spherical Metaparticles

This is the final version. Available on open access from the American Chemical Society via the DOI in this recordData Availability: The data that support the findings of this study are available from the corresponding author upon reasonable request.Geometries that replicate the behavior of metal nanostructures at much lower frequencies via texturing surfaces so they will support a surface wave have been a central pillar of metamaterials research. However, previous work has focused largely on geometries that can be reduced to symmetries in one or two dimensions, such as strips, flat planes, and cylinders. Shapes with isotropic responses in three dimensions are important for applications, such as radar scattering and the replication of certain nanoscale behaviors. This work presents a detailed exploration of the scattering behavior of 3D spherical “spoof plasmonic” metaparticles, based on the platonic solids. Their behavior is compared to an effective medium model through simulation and experiment, and the vast range of behaviors that can be produced from a metal sphere of a given radius via tuning its internal structure is explored in detail.Royal Academy of Engineering (RAE)Engineering and Physical Sciences Research Council (EPSRC

Dark Mode Excitation in Three-Dimensional Interlaced Metallic Meshes

This is the final version. Available on open access from the American Chemical Society via the DOI in this recordData Availability. The data that support the findings of this study are available from the corresponding author upon reasonable request.Interlaced metallic meshes form a class of three-dimensional metamaterials that exhibit nondispersive, broadband modes at low frequencies, without the low frequency cutoff typical of generic wire grid geometries. However, the experimental observation of these modes has remained an open challenge, both due to the difficulties in fabricating such complex structures and also because the broadband mode is longitudinal and does not couple to free-space radiation (dark mode). Here we report the first experimental observation of the low frequency modes in a block of interlaced meshes fabricated through 3D printing. We demonstrate how the addition of monopole antennas to opposing faces of one of the meshes enables coupling of a plane wave to the low frequency “dark mode” and use this to obtain the dispersion of the mode. In addition, we utilize orthogonal antennas on opposite faces to achieve polarization rotation as well as phase shifting of radiation passing through the structure. Our work paves the way toward further experimental study into interlaced meshes and other complex 3D metamaterials.Royal Academy of Engineering (RAE)Engineering and Physical Sciences Research Council (EPSRC

Strong, omnidirectional radar backscatter from subwavelength, 3D printed metacubes

This is the author accepted manuscript. The final version is available from IET via the DOI in this recordMetallic metacubes formed of six metal plate faces connected via a metal jack are shown to backscatter microwave radiation extremely powerfully. Experimental radar scattering cross-section (RCS) data from three-dimensional (3D) printed samples agrees very well with numerical model predictions, showing a monostatic RCS of 15 times the geometric cross-section. The principal resonance of the metacubes demonstrates near-complete independence of the incident angle or polarisation of the radiation, making the metacube an omnidirectional scatterer. The metacubes are fabricated via additive manufacturing from metal-coated polymer, and are extremely lightweight, making them excellent candidates for improving the radar return signals from small objects such as drones and cubesats.Engineering and Physical Sciences Research Council (EPSRC

The Unique Clinical Phenotype and Exercise Adaptation of Fontan Patients With Normal Exercise Capacity

Background: Exercise limitation is almost universal among Fontan patients. Identifying unique clinical features in the small fraction of Fontan patients with normal exercise capacity (high-capacity Fontan [HCF]) provides potential to inform clinical strategies for those with low exercise capacity (usual Fontan). Methods: We performed a retrospective chart review of all patients with single-ventricle physiology palliated with a Fontan operation who underwent incremental cardiopulmonary exercise testing at Cincinnati Children’s Hospital Medical Center from 2013 to 2018. Comparison was between patients with peak oxygen uptake < vs ≥ 80% predicted. Results: A total of 22 of 112 patients were classified as HCF (68% were female; aged 18 ± 7 years). During incremental exercise, peak oxygen uptake (86.1% ± 6.1% vs 62% ± 12.2% predicted; P < 0.001) was greater in HCF vs usual Fontan despite similar chronotropic impairment, resulting in a greater oxygen pulse in HCF. Pulmonary function, breathing reserve, and ventilatory equivalent for CO2 output slope were not different between groups. Those in the HCF group were more likely to self-report exercise ≥ 4 days/week for at least 30 minutes (77% vs 10%, P < 0.001), have normal systolic function (95% vs 74%, P = 0.003), have fewer postoperative complications (8% vs 36%, P = 0.04), and have shorter post-Fontan length of stay (8 ± 2.8 vs 12.4 ± 0.9 days, P = 0.04). Conclusions: Approximately 1 in 5 Fontan patients who undergo cardiopulmonary exercise testing have normal exercise capacity despite chronotropic impairment. This implies a better preserved stroke volume, perhaps due to greater muscle pump-mediated preload. Additionally, a complicated perioperative Fontan course is associated with eventual impaired functional capacity

Microwave backscatter enhancement using radial anisotropy in biomimetic core-shell spheres

This is the final version. Available on open access from the American Institute of Physics via the DOI in this record.Data availability: The data that support the findings of this study are available from the corresponding authors upon reasonable request.Enhanced backscattering of microwave radiation is demonstrated experimentally in a biomimetic radially anisotropic spherical metamaterial component. The core-shell device replicates the optical function of nanospheres observed in the tapetum reflector of the compound eye of the shrimp Litopenaeus vannamei (Boone, 1931) and translates the effect from the optical domain to microwave frequencies. Analytical Mie theory calculations and numerical-method simulations are used to describe the origin of the observed scattering from a single dielectric sphere in terms of its multipolar Mie resonances. The fabrication of components using additive manufacture and their experimental characterization are described. The results show that the introduction of radial anisotropy in the shell more than doubles the monostatic radar cross section compared to the equivalent isotropic case. This work represents a practical demonstration of a synthetic bio-inspired structure, harnessing performance-enhancing adaptations that have evolved in nature. The results augment the range of techniques available for the control of electromagnetic scattering with relevance to applications in the manipulation of radar return signals.Engineering and Physical Sciences Research Council (EPSRC)Royal Academy of Engineerin