Financial analysis of a company

katedra: KFÚ; přílohy: 1 CD; rozsah: 91, 4 s. obr. přílohTato diplomová práce je zaměřena na problematiku finanční analýzy společnosti Desko, a. s. Práce je rozdělena na dvě části: část teoretickou a část praktickou. V teoretické části je popsán základní význam finanční analýzy, její hlavní uživatelé a zdroje informací pro její vypracování. Dále je analyzována problematika nejčastěji používaných metod finanční analýzy. Klíčová pozornost je věnována analýze poměrových ukazatelů, pyramidovému rozkladu vybraného ukazatele, Altmanova modelu a Indexu {\clqq}IN``. Praktická část je zaměřena na samotnou finanční analýzu společnosti Desko, a. s., provedenou za období 2002 - 2005 pomocí vybraných ukazatelů. Následuje pyramidový rozklad ukazatele ROE, Altmanův model a Index {\clqq}IN``. Praktickou část uzavírá porovnání situace mezi jednotlivými středisky společnosti pomocí vybraných ukazatelů za rok 2005. Závěr diplomové práce obsahuje shrnutí a zhodnocení finanční situace daného podniku.This thesis is focused on problems with a financial analysis of the Desko company, a. s. The thesis is divided into two parts: a theoretical part and a practical part. In the theoretical part, the importance of the financial analysis, the main users and the information sources are described. Furthermore, it is followed by an analysis of problems with the most frequent methods used for financial analysis. Special attention applies to an analysis of the financial ratios, pyramidal decomposition of chosen financial ratio, Altman´s model and Index {\clqq}IN``. The practical part is focused on the financial analysis of the Desko company, a. s. over the period 2002 - 2005 with an assistance of the chosen ratios. Next follows the pyramidal decomposition of ROE ratio, Altman´s model and Index {\clqq}IN``. The practical part is closed by comparison of the situation among single departments of the company with an assistance of chosen ratios in the year 2005. The conclusion of the thesis contains a summary of the financial situation of the company

First Wave of Feminism

61 s. +CD ROMTato bakalářská práce se zabývá problematikou feminismu, přesněji řečeno jeho první vlnou. Práce je rozdělena na 2 části. V první části je popsána žena z historického hlediska, připomíná nám roli ženy jak v matriarchální tak v patriarchální společnosti a uvádí významné ženy. V druhé části je podrobněji rozepsána první vlna feminismu. Popisuje vznik ženského hnutí, proudy a hlavní představitele tohoto období

Meta-analysis and systematic review of skin graft donor-site dressings with future guidelines.

Background: Many types of split-thickness skin graft (STSG) donor-site dressings are available with little consensus from the literature on the optimal dressing type. The purpose of this systematic review was to analyze the most recent outcomes regarding moist and nonmoist dressings for STSG donor sites. Methods: A comprehensive systematic review was conducted across PubMed/MEDLINE, EMBASE, and Cochrane Library databases to search for comparative studies evaluating different STSG donor-site dressings in adult subjects published between 2008 and 2017. The quality of randomized controlled trials was assessed using the Jadad scale. Data were collected on donor-site pain, rate of epithelialization, infection rate, cosmetic appearance, and cost. Meta-analysis was performed for reported pain scores. Results: A total of 41 articles were included comparing 44 dressings. Selected studies included analysis of donor-site pain (36 of 41 articles), rate of epithelialization (38 of 41), infection rate (25 of 41), cosmetic appearance (20 of 41), and cost (10 of 41). Meta-analysis revealed moist dressings result in lower pain (pooled effect size = 1.44). A majority of articles (73%) reported better reepithelialization rates with moist dressings. Conclusion: The literature on STSG donor-site dressings has not yet identified an ideal dressing. Although moist dressings provide superior outcomes with regard to pain control and wound healing, there continues to be a lack of standardization. The increasing commercial availability and marketing of novel dressings necessitates the development of standardized research protocols to design better comparison studies and assess true efficacy.R01 EB021308 - NIBIB NIH HHSPublished versio

Development of a human mitochondrial oligonucleotide microarray (h-MitoArray) and gene expression analysis of fibroblast cell lines from 13 patients with isolated F1Fo ATP synthase deficiency

<p>Abstract</p> <p>Background</p> <p>To strengthen research and differential diagnostics of mitochondrial disorders, we constructed and validated an oligonucleotide microarray (h-MitoArray) allowing expression analysis of 1632 human genes involved in mitochondrial biology, cell cycle regulation, signal transduction and apoptosis. Using h-MitoArray we analyzed gene expression profiles in 9 control and 13 fibroblast cell lines from patients with F₁F_oATP synthase deficiency consisting of 2 patients with mt9205ΔTA microdeletion and a genetically heterogeneous group of 11 patients with not yet characterized nuclear defects. Analysing gene expression profiles, we attempted to classify patients into expected defect specific subgroups, and subsequently reveal group specific compensatory changes, identify potential phenotype causing pathways and define candidate disease causing genes.</p> <p>Results</p> <p>Molecular studies, in combination with unsupervised clustering methods, defined three subgroups of patient cell lines – M group with mtDNA mutation and N1 and N2 groups with nuclear defect. Comparison of expression profiles and functional annotation, gene enrichment and pathway analyses of differentially expressed genes revealed in the M group a transcription profile suggestive of synchronized suppression of mitochondrial biogenesis and G1/S arrest. The N1 group showed elevated expression of complex I and reduced expression of complexes III, V, and V-type ATP synthase subunit genes, reduced expression of genes involved in phosphorylation dependent signaling along MAPK, Jak-STAT, JNK, and p38 MAP kinase pathways, signs of activated apoptosis and oxidative stress resembling phenotype of premature senescent fibroblasts. No specific functionally meaningful changes, except of signs of activated apoptosis, were detected in the N2 group. Evaluation of individual gene expression profiles confirmed already known <it>ATP6/ATP8 </it>defect in patients from the M group and indicated several candidate disease causing genes for nuclear defects.</p> <p>Conclusion</p> <p>Our analysis showed that deficiency in the ATP synthase protein complex amount is generally accompanied by only minor changes in expression of ATP synthase related genes. It also suggested that the site (mtDNA vs nuclear DNA) and the severity (ATP synthase content) of the underlying defect have diverse effects on cellular gene expression phenotypes, which warrants further investigation of cell cycle regulatory and signal transduction pathways in other OXPHOS disorders and related pharmacological models.</p

The role of General Assembly of the UN in the fight against apartheid

This thesis is focused on the regime of apartheid in South Africa and the action of the United Nations within the efforts of its dismantling. The aim of this thesis is to evaluate the merits of General Assembly’s operations in the combat against apartheid. The evaluation is based on the analysis of resolutions issued by General Assembly and the historical description leading to the downfall of apartheid.Tato bakalářská práce se zabývá režimem apartheidu v Jihoafrické republice a působením Organizace Spojených národů v rámci jeho rozkladu. Cílem práce je zhodnocení zásluh činnosti Valného shromáždění v boji za odstranění apartheidu. Zhodnocení je provedeno na základě analýzy rezolucí vydaných Valným shromážděním a historické deskripce okolností vedoucí k pádu režimu

Prisoner's Family as an Object of Social Work

The diploma thesis deals with families who face sudden separation of a loved one due to imprisonment. From previous experience the work differs in focusing primarily focused on the family, not prisoners. Theoretical part is devoted to conceptual and legislative definition, the negative effects of imprisonment and the specific needs of the prisoners families as an object of help. Thesis marginally touches on recidivism in the chapter about the family as an entity assist in the reintegration of prisoners and also highlights the potential risks that may family for imprisoned in the process mean. It results from foreign experience, which is traditionally ahead. The empirical part of the qualitative research carried out within of self-help groups of prisoners families provides insight into the specific experiences of families. Its purpose is both to draw attention to this marginalized social group and its needs, as well as outline effective assistance, which would deal with this life situation the best. POTOCKÁ, Veronika. Prisoner's family as an object of social work. Prague, 2014. 121 pages. The diploma thesis. Charles University in Prague, Department of social work. Supervisor: Andrea Matouškov

The unutilized potential of tourism in Spain

This bachelor's thesis deals with the topic of tourism in Spain and its unutilized potential for Czech tourists. Its goal is to analyze the offer of Czech travel agencies within this area and to create new holiday packages and packaged tours sourcing from the results of the analysis. The thesis is divided into 5 chapters. The first one is theoretical and describes the tourism as a whole, Spain and its relations with Czech Republic from various points of view. The second chapter looks into tourism in Spain, its development and conditions for its origin and sustainability in the country. The third chapter is about the current situation of tourism in Spain and is based on statistics and SWOT analysis. The next chapter analyze the offer of chosen Czech travel agencies, both well known and less known and the last chapter contains recommendations for the development of the Czech offer of tourism in Spain including the creation of new holiday packages and packaged tours