Assessing and Computing the Safety Integrity Level (SIL) for Turbo Machinery Protection

Tutoria

Proceedings of the 33rd Annual Meeting, Southern Soybean Disease Workers (March 8-9, 2006, Jackson, Tennessee)

Contents Southern Soybean Disease Workers 2005 treasury report Southern United States Soybean Disease Loss Estimates for 2005. Compiled by SR Koenning Virulence in Phytopbthora sojae Isolates to Soybeans with Rps8 Resistance. DA Smith, TS Abney, and JG Shannon New Sources of Resistance to SCN in Soybean. PR Arelli Soybean Disease Management in Louisiana. B Padgett, MA Purvis, and BW Garber Efficacy and Profitability of Foliar Fungicide in the Absence of Soybean Rust. M Newman and W Percell Fungicide and Insecticide Combinations for Enhancing Soybean Health and Yield. RP Mulrooney and RW Taylor Overview of Soybean Rust Monitoring in the US. JC Rupe Yield Enhancement of Probable Asian Soybean Rust Control Fungicides. JB Blessitt, DH Poston, GL Sciumbato, CH Koger, and N Buehring Occurrence of Disease and Insect Pests in Select Sorghum and Soybean Rotations in Mississippi. ST Pichardo, RE Baird, and HN Pitre A Preliminary Evaluation of Spore Trapping Technology for Phakopsora pachyrhizi. EP Mumma, RW Schneider, CL Robertson, CG Giles, JJ Marois, and DL Wright Influence of Host Genotype and Soybean Cyst Nematode on Charcoal Rot of Soybean. TM Dorton, JP Bond, ME Schmidt, CM Vick, and AK Gregor Comparison of Disease Assessments of Soybean Genotypes in the Presence of Charcoal Rot. A Mengistu, RL Paris, JR Smith, and JD Ray Twenty Years of Soybean Variety Testing for SDS. C Schmidt, J Klein, M Schmidt, and J Bond SCN-Resistant Soybeans Offer a False Sense of Security to Producers. R Heinz, LE Sweets, and MG Mitchum Roundup Ready and Conventional Soybeans with Broad Resistance to SCN HG Types. JG Shannon, JA Wrather, DA Sleper, HT Nguyen, and SC Anand A Review ofReniform Nematode Resistance on Soybean. RT Robbins Effect of Seed Treatments on Soybean Stand and Yield in Arkansas, 2005. JC Rupe, CS Rothrock, TL Kirkpatrick, ML Rosso, and AJ Steger Inheritance of Resistance to Phomopsis Seed Decay in Soybean PI 360841. SE Smith, P Fenn, PK Miller, and P Chen Proceedings of the Southern Soybean Disease Workers are published annually by the Southern Soybean Disease Workers. Text, references, figures, and tables are reproduced as they were submitted by authors. The opinions expressed by the participants at this conference are their own and do not necessarily represent those of the Southern Soybean Disease Workers. Mention of a trademark or proprietary products in this publication does not constitute a guarantee, warranty, or endorsement of that product by the Southern Soybean Disease Workers

Proceedings of the 35th Annual Meeting, Southern Soybean Disease Workers (March 12-13, 2008, Pensacola, Florida)

Contents Southern United States Soybean Disease Loss Estimate for 2007. Compiled by SR Koenning Contributed papers (Clayton Hollier, moderator) Effects of Row Spacing and Leaf Wetness on the Temporal and Spatial Spread of Soybean Rust within Soybean Canopies. DF Narváez, JJ Marois, DL Wright, and S Isard Effects of Potassium, Chloride, and Minor Elements Nutrition on Asian Soybean Rust. RW Schneider, EP Mumma, CL Clark, and CG Giles The Impact of Selected Fungicide Treatments on Disease Progress of Asian Soybean Rust and Other Diseases of Soybean. GB Padgett, MA Purvis, A Hogan, and S Martin Soybean Sudden Death Syndrome Variety Testing at Southern Illinois University. C Herzog, C Schmidt, and M Schmidt Soybean Yield Suppression Due to Diseases for the Top Eight Soybean-Producing Countries in 2006. A Wrather, S Koenning, R Balardin, LH Carregal, R Escobar, GK Gupta, Z Ma, W Morel, LD Ploper, and A Tenuta Impact of Frogeye Leaf Spot on Soybean Yield in the Lower Midwest. CM Vick, AK Vick, JP Bond, and JA Wrather Graduate student papers (Alemu Mengistu, moderator) Laboratory Evaluation of Soybean Resistance to Pod Blight Caused by Cercospora kikuchii. BC Wells and GL Sciumbato Temporal Dynamics of Root and Foliar Symptoms of Soybean Sudden Death Syndrome at Different Inoculum Densities. C Gongora-Canul, FW Nutter, Jr, and LFS Leandro Discussion session (Allen Wrather, moderator) Soybean Rust Sentinal Survey discussion. Don Hershman Proceedings of the Southern Soybean Disease Workers are published annually by the Southern Soybean Disease Workers. Text, references, figures, and tables are reproduced as they were submitted by authors. The opinions expressed by the participants at this conference are their own and do not necessarily represent those of the Southern Soybean Disease Workers. Mention of a trademark or proprietary products in this publication does not constitute a guarantee, warranty, or endorsement of that product by the Southern Soybean Disease Workers

The Parkinson's progression markers initiative (PPMI) - establishing a PD biomarker cohort.

ObjectiveThe Parkinson's Progression Markers Initiative (PPMI) is an observational, international study designed to establish biomarker-defined cohorts and identify clinical, imaging, genetic, and biospecimen Parkinson's disease (PD) progression markers to accelerate disease-modifying therapeutic trials.MethodsA total of 423 untreated PD, 196 Healthy Control (HC) and 64 SWEDD (scans without evidence of dopaminergic deficit) subjects were enrolled at 24 sites. To enroll PD subjects as early as possible following diagnosis, subjects were eligible with only asymmetric bradykinesia or tremor plus a dopamine transporter (DAT) binding deficit on SPECT imaging. Acquisition of data was standardized as detailed at www.ppmi-info.org.ResultsApproximately 9% of enrolled subjects had a single PD sign at baseline. DAT imaging excluded 16% of potential PD subjects with SWEDD. The total MDS-UPDRS for PD was 32.4 compared to 4.6 for HC and 28.2 for SWEDD. On average, PD subjects demonstrated 45% and 68% reduction in mean striatal and contralateral putamen Specific Binding Ratios (SBR), respectively. Cerebrospinal fluid (CSF) was acquired from >97% of all subjects. CSF (PD/HC/SWEDD pg/mL) α-synuclein (1845/2204/2141) was reduced in PD vs HC or SWEDD (P < 0.03). Similarly, t-tau (45/53) and p-tau (16/18) were reduced in PD versus HC (P < 0.01).InterpretationPPMI has detailed the biomarker signature for an early PD cohort defined by clinical features and imaging biomarkers. This strategy provides the framework to establish biomarker cohorts and to define longitudinal progression biomarkers to support future PD treatment trials

Lewy Body Dementia Association\u27s Research Centers of Excellence Program: Inaugural Meeting Proceedings.

The first Lewy Body Dementia Association (LBDA) Research Centers of Excellence (RCOE) Investigator\u27s meeting was held on December 14, 2017, in New Orleans. The program was established to increase patient access to clinical experts on Lewy body dementia (LBD), which includes dementia with Lewy bodies (DLB) and Parkinson\u27s disease dementia (PDD), and to create a clinical trials-ready network. Four working groups (WG) were created to pursue the LBDA RCOE aims: (1) increase access to high-quality clinical care, (2) increase access to support for people living with LBD and their caregivers, (3) increase knowledge of LBD among medical and allied (or other) professionals, and (4) create infrastructure for a clinical trials-ready network as well as resources to advance the study of new therapeutics

Comparison of SARS-CoV-2 serological assays for use in epidemiological surveillance in Scotland

Background: Sero-surveillance of SARS-CoV-2 is crucial to monitoring levels of population exposure and informing public health responses, but may be influenced by variability in performance between available assays. Methods: Five commercial immunoassays and a neutralising activity assay were used to detect antibodies to SARS-CoV-2 in routine primary care and paediatric samples collected during the first wave of the pandemic in NHS Lothian, Scotland as part of ongoing surveillance efforts. For each assay, sensitivity and specificity was calculated relative to consensus results (majority of immunoassays positive = overall positive) and neutralising activity. Quantitative correlation was performed between serological and neutralising titres. Results: Seroprevalence ranged from 3.4–7.3 % in primary care patients and 3–5.9 % in paediatric patients according to different immunoassays. Neutralising activity was detectable in 2.8 % and 1.3 % respectively. Relative assay performance changed depending on comparison to immunoassay consensus versus neutralising activity and qualititative versus quantitative agreement. Cross-reactivity with endemic seasonal coronaviruses was confirmed by neutralising assay in false positives for one immunoassay. Presence of false positives for another assay was found specifically in paediatric but not adult samples. Conclusions: Five serological assays show variable accuracy when applied to the general population, impacting seroprevalence estimates. Assay performance may also vary in detection of protective neutralising antibody levels. These aspects should be considered in assay selection and interpretation in epidemiological studies

Mutational escape from the polyclonal antibody response to SARS-CoV-2 infection is largely shaped by a single class of antibodies

Monoclonal antibodies targeting a variety of epitopes have been isolated from individuals previously infected with SARS-CoV-2, but the relative contributions of these different antibody classes to the polyclonal response remains unclear. Here we use a yeast-display system to map all mutations to the viral spike receptor-binding domain (RBD) that escape binding by representatives of three potently neutralizing classes of anti-RBD antibodies with high-resolution structures. We compare the antibody-escape maps to similar maps for convalescent polyclonal plasma, including plasma from individuals from whom some of the antibodies were isolated. The plasma-escape maps most closely resemble those of a single class of antibodies that target an epitope on the RBD that includes site E484. Therefore, although the human immune system can produce antibodies that target diverse RBD epitopes, in practice the polyclonal response to infection is dominated by a single class of antibodies targeting an epitope that is already undergoing rapid evolution

The Victorian Newsletter (Spring 1960)

The Victorian Newsletter is edited for the English X Group of the Modern Language Association by William E. Buckler, 737 East Building, New York University, New York 3, New York