Propuesta de aplicación de nuevos enfoques de análisis de competencias y perfiles profesionales digitales

El objetivo principal de esta tesis es proponer un nuevo enfoque para el análisis de competencias y perfiles profesionales en el ámbito de las tecnologías de la Información y las Comunicaciones (TIC). La revisión de los métodos de investigación de las contribuciones existentes en el área revela limitaciones y oportunidades de mejora de los resultados del análisis de perfile TIC. Los principales problemas detectados que provocan baja precisión y representatividad en los resultados de análisis de perfiles profesionales son: a) ausencia de terminología y conceptos homogéneos y bien definidos vinculados a modelos o marcos competenciales estándar o ampliamente aceptados, b) limitaciones en la variedad de las fuentes de información y de tamaño y representatividad de los conjuntos de datos para el análisis, c) limitaciones en el diseño y la eficiencia de la recogida de datos, excesivamente basada en métodos manuales y d) análisis excesivamente básico de los datos recogidos con cuestionarios. Por suerte, especialmente en la Unión Europea, el marco de referencia laboral europea ESCO y el estándar EN16234 permiten contar con una terminología homogénea y bien definida en cuanto a competencias, habilidades, conocimientos y actitudes para perfiles profesionales TIC. El modelo Skills Match resultante de un proyecto europeo ofrece una sólida referencia para soft skills. La herramienta OVATE de CEDEFOP permite el análisis de millones de ofertas de trabajo en línea con terminología ESCO y la replicación de la base de datos de ESCO permite consultas sofisticadas de la información de esta clasificación para los perfiles TIC. La aplicación de estas opciones y de otras mejoras metodológicas ha permitido confirmar la mejora de los análisis presentados en tres publicaciones de impacto, con mayor representatividad y tamaño de los datos, una estrecha vinculación a los modelos de referencia existentes y una generación de resultados más sofisticados en forma de marcos competenciales. Gracias a esta confirmación se abre una línea de trabajo para ampliar el alcance y la solidez de los estudios de los perfiles profesionales TIC

THE EXPERIENCE OF DESIGNING CLOTHES TOGETHER WITH STUDENTS OF TECHNOLOGY DEPARTMENT

Lately, questions of cooperation of educational and creative processes have been revitalized. To form future handicraft teacher's expertise in tailoring, it is necessary to develop not only students' technological skills, but also creativity. Creating a collection of clothes is the process aimed at completing these tasks in the form of a specific product. The article presents the Pskov State University students' experience in fashion collection designing cluding the steps of the statement of technological problem, searching for a creative idea and stages of its implementation from the sketch to a ready set.The aim of the article: to describe the experience of developing collections of clothes by students of Pskov State University on the example of the collection “Lazurite”.Research methodology: observation, comparison, analysis, description

Islandinium pacificum sp. nov., a new dinoflagellate cyst from the upper Quaternary of the northeast Pacific

Round brown process-bearing cysts (RBPC) produced by dinoflagellates (Dinophyceae) occur as an important part of assemblage diversities in seafloor sediments worldwide. Here a new species, Islandinium pacificum, is described from surface sediment samples from coastal waters of British Columbia (Canada). Additional observations are made on material from the Holocene of Kyuquot Sound (Vancouver Island, Canada) and the Eemian of the Voring Plateau (North Atlantic). The cysts have a smooth wall and bear acuminate processes with barbs. Incubation experiments reveal an affinity with the motile stage Protoperidinium mutsuense. The ecology of the new species is specified

STUDYING THE ELEMENTS OF THE RUSSIAN NATIONAL CULTURE AT TECHNOLOGY LESSONS

The analysis of the technology at school program is carried out in the research. Studying the national culture plays an important role on technology lessons. It is possible to study people’s life features in a deeper way. Also it is possible to feel belonging to the culture. The methodical recommendations of the training organization with the elements of national culture at technology classes are in 5 and 8 classes.

A36 The TP53 mutations in the Russian patients with de novo DLBCL

BackgroundTP53 dysfunction is implicated in lymphomagenesis and disease progression. Information about the frequency and spectrum of TP53 mutations in the Russian pathients with diffuse large B-cell lymphoma (DLBCL) in the current version of the IARC TP53 Mutation Database R17 is not represented. The goal of this work was to study the frequency, spectrum and functional significance of TP53 mutations in Russian patients with DLBCL.Material and methodsAt the present time the pilot group of 14 patients were included in the study. Diagnosis was assessed according to the criteria of the WHO classification system. Genomic DNA was isolated from formalin-fixed, paraffin embedded tissue blocks. Direct sequence analysis of gene TP53 was performed according to the IARC protocol, 2010 update.ResultsIn two patients were identified single nucleotide substitutions that are not described in the current version of the PubMed database. All of mutations occurred in the DNA-binding domain of p53. The nonsense mutation Arg196Ter was detected in one patient. Previously it was shown that formation of this premature stop codon might activate the nonsense-mediated RNA decay pathway. The second patient had two missense mutations – Leu130Phe and Arg156Cys. The first of them leads to p53 inactivation according to the analysis of the functional importance of amino acid substitutions using service PolyPhen-2.ConclusionWe detected TP53 mutation in 14% cases. The mutational rate in our study is in good agreement with other studies where the frequency of the TP53 mutations in patients with DLBCL ranged mostly from 13% to 23%

New possibilities of the functionalization of 6-hydrazino-1,3-dimethyluracils: one-pot synthesis of 5,7-dimethylpyrazolopyrimidine-4,6-dione and 1,3-dimethyl-5-arylidenebarbituric acid derivatives

3-aryl-5,7-dimethylpyrazolopyrimidine-4,6-diones and 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-triones were obtained by heating hydrazones of 1,3-dimethyl-6 -hydrazinouraciles in trifluoroacetic acid (TFA). The same compounds were also obtained by heating the hydrazones of 1,3-dimethyl-6-hydrazinouraciles in aqueous ethanol in the presence of hydrochloric acid.3-aryl-5,7-dimethylpyrazolopyrimidine-4,6-diones and 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-triones were obtained by heating hydrazones of 1,3-dimethyl-6 -hydrazinouraciles in trifluoroacetic acid (TFA). The same compounds were also obtained by heating the hydrazones of 1,3-dimethyl-6-hydrazinouraciles in aqueous ethanol in the presence of hydrochloric acid

Микрофлора семян расторопши пятнистой (Silybum marianum (L.) Gaertn.)

Викладено результати фітоекспертизи насіння розторопші плямистої (Silybum marianum (L.) Gaertn.). Охарактеризовано показники якості, ступінь інфікованості та видовий склад патогенних мікроорганізмів. Визначено 7 видів грибів, які за класифікацією належать до двох класів: Deuteromycetes (види родів Fusarium, Alternaria, Botrytis, Sordariomycetes) та Zygomycetes (представники роду Mucor). Виявлено, що серед ідентифікованих мікроміцетів переважали гриби із родів Alternaria та Mucor (22 і 52 % відповідно). Менш поширеними були гриби родів Fusarium, Botrytis та Stachybotrys. Заспореність ними змінювалася від 1 до 7 %.The results of phytoexamination of Milk Thistle seeds are provided. Quality indicators, the degree of infestation and species composition of pathogenic microorganisms are characterised. Seven species of fungi, which in accordance with the classification belong to two classes: Deuteromycetes (species of the genera Fusarium, Alternaria, Botrytis), Stachybotrys) and Zygomycetes (representatives of the genus Mucor), are defined. Fungi of the genera Alternaria and Mucor (13-21 % and 24-44 % respectively) are revealed to dominate among the identified micromycetes. The fungi of the genera Fusarium, Botrytis and Stachybotrys appeared to be less common. The number of fungal spores ranged from 1 to 7 %.Представлены результаты фитоэкспертизы семян расторопши пятнистой. Охарактеризованы показатели качества, степень зараженности и видовой состав патогенных микроорганизмов. Определено 7 видов грибов, которые в соответствии с классификацией относятся к двум классам: Deuteromycetes (виды родов Fusarium, Alternaria, Botrytis), Stachybotrys) и Zygomycetes (представители рода Mucor). Среди идентифицированных микромицетов преобладали грибы из родов Alternaria и Mucor (13-21 % и 24-44 % соответственно). Менее распространенными были грибы родов Fusarium, Botrytis и Stachybotrys. Заспоренность ими варьировала от 1 до 7 %

Comparative habitat selection by muskoxen introduced to northeastern Alaska and the Taimyr Peninsula, Russia

Muskoxen (Ovibos moschatus) introduced to formerly occupied areas in northeastern Alaska (70°N) in 1969 and 1970, and the Taimyr Peninsula (75°N) in 1974 and 1975 increased in number (exceeding 20%/year in the early years following their establishment), and have expaned into available habitats. Vegetation of the two areas share many similarities, although richness of vascular plant species is greater in Alaska (350) than in the Taimyr (230). Seasonal partitioning of range use is similar in both areas with low-lying tussock tundra being used primarily from summer through early to mid-winter. By late winter, when snow accumulation in low areas and on lower slopes of hills limits access to forage, muskoxen concentrate activity on drier ridge tops and river and coastal bluffs with little snow accumulation. Riparian habitats appear to receive greater year round use in Alaska than in the Taimyr