Aplikasi Kompos Ganggang Cokelat (Sargassum Polycystum) Diperkaya Pupuk N, P, K Terhadap Inseptisol Dan Jagung

This research aimed to determine the effect of brown algae compost (Sargassum polycystum)enriched with various of dosage N, P and K fertilizer against inceptisol chemical properties andmaize. This research was conducted in June – October 2013 using non-factorial randomized blockdesign, with 7 treatment and 4 replication. That is P0 (not enriched brown algae compost), P1, P2,P3, P4, P5, and P6 (compost enriched urea 2g and 4g dosage level, SP36 2g and 4g dosage level,KCl 0,5g and 1g dosage level). Applied before the vegetative period (when beginning to cultivatethe land) and before the generative period. Parameters measured d canopy, and cob with cornhuskweight. The results showed that brown algae enriched compost significantly affect the pH (H2O),K-exchange soil, plant height and cob with cornhusk. The best dosage is P5 (brown algae compostenriched with urea 4g, SP36 2g, and KCl 0,5g application on early vegetatif and urea 2g, SP36 2g,dan KCl 1g application at the end of vegetative period) against cornhusk cob weight and dry weightof maize plant canopy

Time courses of urinary creatinine excretion, measured creatinine clearance and estimated glomerular filtration rate over 30 days of ICU admission

Purpose: Baseline urinary creatinine excretion (UCE) is associated with ICU outcome, but its time course is not known. Materials and methods: We determined changes in UCE, plasma creatinine, measured creatinine clearance (mCC) and estimated glomerular filtration (eGFR) in patients with an ICU-stay 30d without acute kidney injury stage 3. The Cockcroft-Gault, MDRD (modification of diet in renal disease) and CKD-EPI (chronic kidney disease epidemiology collaboration) equations were used. Results: In 248 patients with 5143 UCEs hospital mortality was 24%. Over 30d, UCE absolutely decreased in male survivors and non-survivors and female survivors and nonsurvivors by 0.19, 0.16, 0.10 and 0.05 mmol/d/d (all P < 0.001). Relative decreases in UCE were similar in all four groups: 1.3, 1.4, 1.2 and 0.9%/d respectively. Over 30d, mCC remained unchanged, but eGFR rose by 31% (CKD-EPI) and 73% (MDRD) and creatinine clearance estimated by Cockcroft-Gault by 59% (all P < 0.001). Conclusions: Over 1 month of ICU stay, UCE declined by 1%/d which may correspond to an equivalent decline in muscle mass. These rates of UCE decrease were similar in survivors, non-survivors, males and females underscoring the intransigent nature of this process. In contrast to measured creatinine clearance, estimates of eGFR progressively rose during ICU stay. (c) 2020 Published by Elsevier Inc

Levels of the cancer biomarker CA 19-9 are associated with thrombin generation in plasma from treatment-na?ve pancreatic cancer patients

Background: Pancreatic ductal adenocarcinoma (PDAC) is associated with a hypercoagulable state and high mortality. Increases in the plasma levels of tumor marker carbohydrate antigen (CA) 19-9 are used in diagnosis and follow-up but have also been reported to precede venous thromboembolism (VTE). Aims: We examined the association between CA 19-9 and thrombin generation (TG) in plasma from PDAC patients, as well as their association with coagulation biomarkers prior to pancreatic surgery. In addition, we determined the effect of commercial sources of CA 19-9 on TG. Methods: We collected plasma from 58 treatment-naive PDAC patients without any signs of VTE. We measured levels of CA 19-9, FVIII, fibrinogen, D-dimer, antithrombin and extracellular vesicle (EV) tissue factor (TF) activity and TG using a Calibrated Automated Thrombogram (CAT). The effect of different commercial sources of CA 19-9 on TG in Standard Human Plasma (SHP) was also studied. Results: Patient plasma samples were divided into 4 preoperative groups based on the level of CA 19-9: none 1000 U/mL. CA 19-9 levels were associated with several of the TG parameters, including endogenous thrombin potential, peak, and time to peak. CA 19-9 did not associate with any of the coagulation biomarkers. Spiking of SHP with CA 19-9 increased TG but this was decreased by an antiTF antibody. Conclusions: CA 19-9 was associated with TG in patients prior to any pancreatic cancer treatments or signs of VTE. Some commercial sources of CA 19-9 enhanced TG in SHP seemingly due to contaminating TF.Peer reviewe

Early lactate and glucose kinetics following return to spontaneous circulation after out-of-hospital cardiac arrest

OBJECTIVE: Lactate has been shown to be preferentially metabolized in comparison to glucose after physiological stress, such as strenuous exercise. Derangements of lactate and glucose are common after out-of-hospital cardiac arrest (OHCA). Therefore, we hypothesized that lactate decreases faster than glucose after return-to-spontaneous-circulation (ROSC) after OHCA. RESULTS: We included 155 OHCA patients in our analysis. Within the first 8 h of presentation to the emergency department, 843 lactates and 1019 glucoses were available, respectively. Lactate decreased to 50% of its initial value within 1.5 h (95% CI [0.2-3.6 h]), while glucose halved within 5.6 h (95% CI [5.4-5.7 h]). Also, in the first 8 h after presentation lactate decreases more than glucose in relation to their initial values (lactate 72.6% vs glucose 52.1%). In patients with marked hyperlactatemia after OHCA, lactate decreased expediently while glucose recovered more slowly, whereas arterial pH recovered at a similar rapid rate as lactate. Hospital non-survivors (N = 82) had a slower recovery of lactate (P = 0.002) than survivors (N = 82). The preferential clearance of lactate underscores its role as a prime energy substrate, when available, during recovery from extreme stress

Pemberian Motivasi Cinta Lingkungan Kepada Siswasiswi SMA

Kerusakan kualitas lingkungan disebabkan juga oleh sistem pendidikan yang tidak memperhatikanpendidikan lingkungan terhadap anak didik sejak dini. Tujuan pengabdian kepada masyarakat ini adalahmemberikan motivasi kepada siswa-siswa SMA dalam memelihara lingkungan sejak dini. Metodologi penulisanlaporan ini adalah dengan metode deskriptif. Metode pelaksanaan diawali dengan rapat perencanaan, persiapanbahan, pelaksanaan dan evaluasi. Kegiatan pelaksanaan dilakukan dengan mengumpulkan siswa-siswi SMA dariPerguruan Advent Bogor dalam suatu kelas, lalu diberikan paparan mengapa mereka perlu mencintailingkungan demi generasi mereka sendiri. Perhatian utama yang menjadi acuan adalah lingkungan sungai,karena semua sampah pada akhirnya akan hanyut ke aliran sungai menuju laut. Pemaparan juga mengenaiSungai Citarum yang menjadi perhatian dunia karena sangat kotor dan sampai saat ini belum dapat dibersihkansecara baik. Para peserta, siswa-siswi dan guru-guru, memperhatikan dengan seksama dan banyak bertanyamengenai siapa yang bertanggung jawab mengenai kelestarian lingkungan apakah pemesrintah atau pihaklainnya. Pihak yang terutama menjaga lingkungan adalah diri sendiri agar lingkungan yang bersih dapatdinikmati secara baik sampai dengan generasi yang akan datang

Pelatihan Beriventasi Sejak Dini di Pasar Modal

Pasar Modal di Bursa Efek Indonesia (BEI) memudahkan para masyarakat untuk mengelola dananya dipasar modal. Aktivitas di BEI merupakan tempat bertemunya antara Perusahaan yang membutuhkan danadan para investor yang mempunyai dana untuk di investasikan dengan menabung saham. Pelatihan yangdilakukan di Perguruan Advent Bogor merupakan bentuk untuk mengajak Siswa-Siswi, Guru, dan WargaPerguruan Advent Bogor untuk berinvestasi sejak dini yang diprogramkan pemerintah yaitu Yuk NabungSaham. Tujuan khusus dari Pelatihan Kepada Masayarakat adalah Penyampain materi, diskusi dan simulasi.Perguruan Advent Bogor, yang terus berkelanjutan untuk ikut berperan aktif menjadi investor di BursaEfek Jakart

Metformin Preconditioning and Postconditioning to Reduce Ischemia Reperfusion Injury in an IsolatedEx VivoRat and Porcine Kidney Normothermic Machine Perfusion Model

Metformin may act renoprotective prior to kidney transplantation by reducing ischemia-reperfusion injury (IRI). This study examined whether metformin preconditioning and postconditioning duringex vivonormothermic machine perfusion (NMP) of rat and porcine kidneys affect IRI. In the rat study, saline or 300 mg/kg metformin was administered orally twice on the day before nephrectomy. After 15 minutes of warm ischemia, kidneys were preserved with static cold storage for 24 hours. Thereafter, 90 minutes of NMP was performed with the addition of saline or metformin (30 or 300 mg/L). In the porcine study, after 30 minutes of warm ischemia, kidneys were preserved for 3 hours with oxygenated hypothermic machine perfusion. Subsequently, increasing doses of metformin were added during 4 hours of NMP. Metformin preconditioning of rat kidneys led to decreased injury perfusate biomarkers and reduced proteinuria. Postconditioning of rat kidneys resulted, dose-dependently, in less tubular cell necrosis and vacuolation. Heat shock protein 70 expression was increased in metformin-treated porcine kidneys. In all studies, creatinine clearance was not affected. In conclusion, both metformin preconditioning and postconditioning can be done safely and improved rat and porcine kidney quality. Because the effects are minor, it is unknown which strategy might result in improved organ quality after transplantation

Prognostic impact of elevated lactate levels on mortality in critically ill patients with and without preadmission metformin treatment:a Danish registry-based cohort study

BACKGROUND: Lactate is a robust prognostic marker for the outcome of critically ill patients. Several small studies reported that metformin users have higher lactate levels at ICU admission without a concomitant increase in mortality. However, this has not been investigated in a larger cohort. We aimed to determine whether the association between lactate levels around ICU admission and mortality is different in metformin users compared to metformin nonusers. METHODS: This cohort study included patients admitted to ICUs in northern Denmark between January 2010 and August 2017 with any circulating lactate measured around ICU admission, which was defined as 12 h before until 6 h after admission. The association between the mean of the lactate levels measured during this period and 30-day mortality was determined for metformin users and nonusers by modelling restricted cubic splines obtained from a Cox regression model. RESULTS: Of 37,293 included patients, 3183 (9%) used metformin. The median (interquartile range) lactate level was 1.8 (1.2-3.2) in metformin users and 1.6 (1.0-2.7) mmol/L in metformin nonusers. Lactate levels were strongly associated with mortality for both metformin users and nonusers. However, the association of lactate with mortality was different for metformin users, with a lower mortality rate in metformin users than in nonusers when admitted with similar lactate levels. This was observed over the whole range of lactate levels, and consequently, the relation of lactate with mortality was shifted rightwards for metformin users. CONCLUSION: In this large observational cohort of critically ill patients, early lactate levels were strongly associated with mortality. Irrespective of the degree of hyperlactataemia, similar lactate levels were associated with a lower mortality rate in metformin users compared with metformin nonusers. Therefore, lactate levels around ICU admission should be interpreted according to metformin use