Vanishing chiral couplings in the large-N_C resonance theory

The construction of a resonance theory involving hadrons requires implementing the information from higher scales into the couplings of the effective Lagrangian. We consider the large-Nc chiral resonance theory incorporating scalars and pseudoscalars, and we find that, by imposing LO short-distance constraints on form factors of QCD currents constructed within this theory, the chiral low-energy constants satisfy resonance saturation at NLO in the 1/Nc expansion.Comment: 5 pages, 2 figures. Version published in Physical Review D. Some equations to facilitate the discussion have been adde

Lepton Flavour Violation in charged leptons within SUSY-seesaw

In this paper we review our main results for Lepton Flavour Violating (LFV) semileptonic tau decays and muon-electron conversion in nuclei within the context of two Constrained SUSY-Seesaw Models, the CMSSM and the NUHM. The relevant spectrum is that of the Minimal Supersymmetric Standard Model extended by three right handed neutrinos, $\nu_{R_i}$ and their corresponding SUSY partners, ${\tilde \nu}_{R_i}$, ($i=1,2,3$). We use the seesaw mechanism for neutrino mass generation and choose a parameterisation of this mechanism that allows us to incorporate the neutrino data in our analysis of LFV processes. In addition to the full one-loop results for the rates of these processes, we will also review the set of simple formulas, valid at large $\tan \beta$, which are very useful to compare with present experimental bounds. The sensitivity to SUSY and Higgs sectors in these processes will also be discussed. This is a very short summary of the works in Refs. \cite{Arganda:2008jj} and \cite{Arganda:2007jw} to which we refer the reader for more details.Comment: 6 pages, 6 figures. To be published in the proceedings of the Tau08 Conference, Novosibirsk, Russia, 22-25 September 200

Hadron structure in tau -> KKpi nu_tau decays

We analyse the hadronization structure of both vector and axial-vector currents leading to tau -> KKpi nu_tau decays. At leading order in the 1/Nc expansion, and considering only the contribution of the lightest resonances, we work out, within the framework of the resonance chiral Lagrangian, the structure of the local vertices involved in those processes. The couplings in the resonance theory are constrained by imposing the asymptotic behaviour of vector and axial-vector spectral functions ruled by QCD. In this way we predict the hadron spectra and conclude that, contrarily to previous assertions, the vector contribution dominates by far over the axial-vector one in all KKpi charge channels.Comment: 32 pages, 7 figure

Las fosfatidilinositol 3-cinasas de clase I en la inmunidad: Efecto de inhibidores en respuestas inmunes y autoinmunes

Las fosfatidilinositol 3-cinasas (PI3K) de clase I dan lugar a fosfolípidos trifosforilados (PtdIns(3,4,5)P3) que son clave en las señales de crecimiento, diferenciación y la supervivencia de las células y son esenciales para el funcionamiento de la inmunidad innata y adaptativa. Los nuevos inhibidores de PI3K generados para el tratamiento de tumores pueden ser útiles en inmunoterapia, especialmente en enfermedades autoinmunes, y ha de investigarse su impacto en la inmunidad anti tumoral. Se revisa el papel de las PI3K de clase I en las respuestas inmunes adaptativas, y los datos conocidos relativos al efecto de inhibidores en respuestas inmunes adaptativas.Las fosfatidilinositol 3-cinasas (PI3K) de clase I dan lugar a fosfolípidos trifosforilados (PtdIns(3,4,5)P3) que son clave en las señales de crecimiento, diferenciación y la supervivencia de las células y son esenciales para el funcionamiento de la inmunidad innata y adaptativa. Los nuevos inhibidores de PI3K generados para el tratamiento de tumores pueden ser útiles en inmunoterapia, especialmente en enfermedades autoinmunes, y ha de investigarse su impacto en la inmunidad anti tumoral. Se revisa el papel de las PI3K de clase I en las respuestas inmunes adaptativas, y los datos conocidos relativos al efecto de inhibidores en respuestas inmunes adaptativas

Dificultades algebraicas en la resolución de problemas por transferencia

La enseñanza de resolución de problemas en ciencias y matemáticas se realiza en general mediante estrategias de transferencia (transfer): se resuelve y explica un conjunto de problemas y después se pide a los estudiantes que resuelvan otros problemas análogos a los ejemplos trabajados. Los profesores de Secundaria con frecuencia asumen que las relaciones analógicas entre los problemas resueltos y los problemas propuestos son sencillas de comprender y establecer, y atribuyen el fracaso a la falta de dominio de los procedimientos matemáticos de resolución. En este trabajo se realiza un experimento para probar si esta atribución causal es adecuada o no. Los resultados demuestran que la causa principal de las dificultades debe tener su origen en la construcción de un modelo de la situación y/o de un modelo del problema, adecuados

Evidence of topological superconductivity in planar Josephson junctions

Majorana zero modes are quasiparticle states localized at the boundaries of topological superconductors that are expected to be ideal building blocks for fault-tolerant quantum computing. Several observations of zero-bias conductance peaks measured in tunneling spectroscopy above a critical magnetic field have been reported as experimental indications of Majorana zero modes in superconductor/semiconductor nanowires. On the other hand, two dimensional systems offer the alternative approach to confine Ma jorana channels within planar Josephson junctions, in which the phase difference {\phi} between the superconducting leads represents an additional tuning knob predicted to drive the system into the topological phase at lower magnetic fields. Here, we report the observation of phase-dependent zero-bias conductance peaks measured by tunneling spectroscopy at the end of Josephson junctions realized on a InAs/Al heterostructure. Biasing the junction to {\phi} ~ {\pi} significantly reduces the critical field at which the zero-bias peak appears, with respect to {\phi} = 0. The phase and magnetic field dependence of the zero-energy states is consistent with a model of Majorana zero modes in finite-size Josephson junctions. Besides providing experimental evidence of phase-tuned topological superconductivity, our devices are compatible with superconducting quantum electrodynamics architectures and scalable to complex geometries needed for topological quantum computing.Comment: main text and extended dat

Form Factors in the radiative pion decay

We perform an analysis of the form factors that rule the structure-dependent amplitude in the radiative pion decay. The resonance contributions to pion -> e nu_e gamma decays are computed through the proper construction of the vector and axial-vector form factors by setting the QCD driven asymptotic properties of the three-point Green functions VVP and VAP, and by demanding the smoothing of the form factors at high transfer of momentum. A comparison between theoretical and experimental determinations of the form factors is also carried out. We also consider and evaluate the role played by a non-standard tensor form factor. We conclude that, at present and due to the hadronic incertitudes, the search for New Physics in this process is not feasible.Comment: 14 pages, no figures. Typos corrected. Accepted for publication in The European Physical Journal

Tailoring hierarchical meso- macroporous 3D scaffolds: from nano to macro

Bone tissue regeneration requires the use of 3D scaffolds which mimic the architecture of the natural extracellular matrix, creating an adequate microenvironment for bone cell growth. Such 3D scaffolds need surface properties suitable for biological recognition in the early stage of cell adhesion, necessary to ensure complete cell colonization, retained cell functionality, and subsequently bone regeneration. Herein, hierarchical 3D scaffolds based on new hydroxyapatite/mesoporous glass nanocomposite bioceramic (MGHA) exhibiting different scales of porosity have been synthesized. These 3D scaffolds possess: (i) highly ordered mesopores with diameters of 10 nm; (ii) macropores with diameters in the 30-80 mu m range with interconnections of 1-10 mu m; and (iii) large macropores of ca. 500 mu m. To improve their surface properties, 3D scaffolds were modified through direct functionalization with amine propyl groups, which notably improve preosteoblast adhesion, proliferation (2.3 fold), differentiation (4.8 fold) and further cell colonization of these scaffolds. The observed enhancement can be related to these amine groups which favour early adhesion, e. g., based on nonspecific protein adsorption as was demonstrated by ellipsometry. These results suggest that the combination of hierarchical structure design and amine surface modification of hydroxyapatite/mesoporous nanocomposite scaffolds yields a double increase in cell proliferation, as well as a quadruple increase in cell differentiation, demonstrating the potential of these nanocomposite materials for bone tissue regeneration purposes

The vector form factor of the pion from unitarity and analyticity: a model-independent approach

We study a model-independent parameterization of the vector pion form factor that arises from the constraints of analyticity and unitarity. Our description should be suitable up to sqrt(s) ~ 1.2 GeV and allows a model-independent determination of the mass of the rho(770) resonance, M(rho) = (775.1 +- 0.5) MeV. We analyse the experimental data on tau(-) -> pion(-) pion(0) neutrino(tau), in this framework, and its consequences on the low-energy observables worked out by chiral perturbation theory. An evaluation of the two-pion contribution to the anomalous magnetic moment of the muon, a_muon, and to the fine structure constant, alpha(M(Z)^2), is also performed.Comment: 1+15 pages, 2 figure