3,886 research outputs found
Universality in one-dimensional fermions at finite temperature: Density, pressure, compressibility, and contact
We present finite-temperature, lattice Monte Carlo calculations of the
particle number density, compressibility, pressure, and Tan's contact of an
unpolarized system of short-range, attractively interacting spin-1/2 fermions
in one spatial dimension, i.e., the Gaudin-Yang model. In addition, we compute
the second-order virial coefficients for the pressure and the contact, both of
which are in excellent agreement with the lattice results in the low-fugacity
regime. Our calculations yield universal predictions for ultracold atomic
systems with broad resonances in highly constrained traps. We cover a wide
range of couplings and temperatures and find results that support the existence
of a strong-coupling regime in which the thermodynamics of the system is
markedly different from the noninteracting case. We compare and contrast our
results with identical systems in higher dimensions.Comment: 6 pages, 7 figures; improved, published versio
Estimated annual economic impacts from harmful algal blooms (HABs) in the United States
Blooms of toxic or harmful microalgae, commonly called "red tides," represent a significant and expanding threat to human
health and fisheries resources throughout the United States and the world. Ecological, aesthetic, and public health impacts
include: mass mortalities of wild and farmed fish and shellfish, human intoxication and death from the consumption of
contaminated shellfish or fish, alterations of marine food webs through adverse effects on larvae and other life history stages of
commercial fish species, the noxious smell and appearance of algae accumulated in nearshore waters or deposited on beaches, and
mass mortalities of marine mammals, seabirds, and other animals.
In this report, we provide an estimate of the economic impacts of HABs in the United States from events where such impacts
were measurable with a fair degree of confidence during the interval 1987-92. The total economic impact averaged $49 million
per year, with public health impacts representing the largest component (45 percent). Commercial fisheries impacts were the next
largest (37 percent of the total), while recreation/tourism accounted for 13 percent, and monitoring/management impacts 4 percent.
These estimates are highly conservative, as many economic costs or impacts from HABs could not be estimated.Funding was provided by the National Oceanic and Atmospheric
Administration under Grants No. NA46RG0470 and NA90AA-D-SG480, the
National Science Foundation under Grant No. OCE-9321244, and the Johnson
Endowment of the Marine Policy Center
A basic optimization problem in linear systems
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/48017/1/224_2005_Article_BF01691464.pd
Modulated Amplitude Waves in Bose-Einstein Condensates
We analyze spatio-temporal structures in the Gross-Pitaevskii equation to
study the dynamics of quasi-one-dimensional Bose-Einstein condensates (BECs)
with mean-field interactions. A coherent structure ansatz yields a
parametrically forced nonlinear oscillator, to which we apply Lindstedt's
method and multiple-scale perturbation theory to determine the dependence of
the intensity of periodic orbits (``modulated amplitude waves'') on their wave
number. We explore BEC band structure in detail using Hamiltonian perturbation
theory and supporting numerical simulations.Comment: 5 pages, 4 figs, revtex, final form of paper, to appear in PRE
(forgot to include \bibliography command in last update, so this is a
correction of that; the bibliography is hence present again
Excitation Spectrum and Superexchange Pathways in the Spin Dimer VODPO_4 . 1/2 D_2O
Magnetic excitations have been investigated in the spin dimer material
VODPO_4 \cdot 1/2 D_2O using inelastic neutron scattering. A dispersionless
magnetic mode was observed at an energy of 7.81(4) meV. The wavevector
dependence of the scattering intensityfrom this mode is consistent with the
excitation of isolated V^{4+} spin dimers with a V-V separation of 4.43(7) \AA.
This result is unexpected since the V-V pair previously thought to constitute
themagnetic dimer has a separation of 3.09 \AA. We identify an alternative V-V
pair as the likely magnetic dimer, which involves superexchange pathways
through a covalently bonded PO_4 group. This surprising result casts doubt on
the interpretation of (VO)_2P_2O_7 as a spin ladder.Comment: 4 pages, 4 postscript figures - identical to previous paper but
figure 2 and 3 hopefully more compatible .p
Coexistence of opposite opinions in a network with communities
The Majority Rule is applied to a topology that consists of two coupled
random networks, thereby mimicking the modular structure observed in social
networks. We calculate analytically the asymptotic behaviour of the model and
derive a phase diagram that depends on the frequency of random opinion flips
and on the inter-connectivity between the two communities. It is shown that
three regimes may take place: a disordered regime, where no collective
phenomena takes place; a symmetric regime, where the nodes in both communities
reach the same average opinion; an asymmetric regime, where the nodes in each
community reach an opposite average opinion. The transition from the asymmetric
regime to the symmetric regime is shown to be discontinuous.Comment: 14 pages, 4 figure
Engineering gamma delta T cells limits tonic signaling associated with chimeric antigen receptors
Despite the benefits of chimeric antigen receptor (CAR)–T cell therapies against lymphoid malignancies, responses in solid tumors have been more limited and off-target toxicities have been more marked. Among the possible design limitations of CAR-T cells for cancer are unwanted tonic (antigen-independent) signaling and off-target activation. Efforts to overcome these hurdles have been blunted by a lack of mechanistic understanding. Here, we showed that single-cell analysis with time course mass cytometry provided a rapid means of assessing CAR-T cell activation. We compared signal transduction in expanded T cells to that in T cells transduced to express second-generation CARs and found that cell expansion enhanced the response to stimulation. However, expansion also induced tonic signaling and reduced network plasticity, which were associated with expression of the T cell exhaustion markers PD-1 and TIM-3. Because this was most evident in pathways downstream of CD3ζ, we performed similar analyses on γδT cells that expressed chimeric costimulatory receptors (CCRs) lacking CD3ζ but containing DAP10 stimulatory domains. These CCR-γδT cells did not exhibit tonic signaling but were efficiently activated and mounted cytotoxic responses in the presence of CCR-specific stimuli or cognate leukemic cells. Single-cell signaling analysis enabled detailed characterization of CAR-T and CCR-T cell activation to better understand their functional activities. Furthermore, we demonstrated that CCR-γδT cells may offer the potential to avoid on-target, off-tumor toxicity and allo-reactivity in the context of myeloid malignancies
Sublocalization, superlocalization, and violation of standard single parameter scaling in the Anderson model
We discuss the localization behavior of localized electronic wave functions
in the one- and two-dimensional tight-binding Anderson model with diagonal
disorder. We find that the distributions of the local wave function amplitudes
at fixed distances from the localization center are well approximated by
log-normal fits which become exact at large distances. These fits are
consistent with the standard single parameter scaling theory for the Anderson
model in 1d, but they suggest that a second parameter is required to describe
the scaling behavior of the amplitude fluctuations in 2d. From the log-normal
distributions we calculate analytically the decay of the mean wave functions.
For short distances from the localization center we find stretched exponential
localization ("sublocalization") in both, 1d and 2d. In 1d, for large
distances, the mean wave functions depend on the number of configurations N
used in the averaging procedure and decay faster that exponentially
("superlocalization") converging to simple exponential behavior only in the
asymptotic limit. In 2d, in contrast, the localization length increases
logarithmically with the distance from the localization center and
sublocalization occurs also in the second regime. The N-dependence of the mean
wave functions is weak. The analytical result agrees remarkably well with the
numerical calculations.Comment: 12 pages with 9 figures and 1 tabl
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Research-based versus clinical serum creatinine measurements and the association of acute kidney injury with subsequent kidney function: findings from the Chronic Renal Insufficiency Cohort study.
Background:Observational studies relying on clinically obtained data have shown that acute kidney injury (AKI) is linked to accelerated chronic kidney disease (CKD) progression. However, prior reports lacked uniform collection of important confounders such as proteinuria and pre-AKI kidney function trajectory, and may be susceptible to ascertainment bias, as patients may be more likely to undergo kidney function testing after AKI. Methods:We studied 444 adults with CKD who participated in the prospective Chronic Renal Insufficiency Cohort (CRIC) Study and were concurrent members of a large integrated healthcare delivery system. We estimated glomerular filtration rate (eGFR) trajectories using serum creatinine measurements from (i) the CRIC research protocol (yearly) and (ii) routine clinical care. We used linear mixed effects models to evaluate the associations of AKI with acute absolute change in eGFR and post-AKI eGFR slope, and explored whether these varied by source of creatinine results. Models were adjusted for demographic characteristics, diabetes status and albuminuria. Results:During median follow-up of 8.5 years, mean rate of eGFR loss was -0.31 mL/min/1.73 m2/year overall, and 73 individuals experienced AKI (55% Stage 1). A significant interaction existed between AKI and source of serum creatinine for acute absolute change in eGFR level after discharge; in contrast, AKI was independently associated with a faster rate of eGFR decline (mean additional loss of -0.67 mL/min/1.73 m2/year), which was not impacted by source of serum creatinine. Conclusions:AKI is independently associated with subsequent steeper eGFR decline regardless of the serum creatinine source used, but the strength of association is smaller than observed in prior studies after taking into account key confounders such as pre-AKI eGFR slope and albuminuria
Distributed global debris thickness estimates reveal debris significantly impacts glacier mass balance
International audienc
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