Experimental studies of the effect of rapid afterburn on shock development of near-field explosions

Many conventional high explosives do not contain sufficient internal oxygen to fully combust the gaseous products which result from detonation of the explosive material. Because of this, under-oxygenated explosives continue to burn after detonation. This process, called afterburn, is known to influence the late-time pressure and energy released by the explosive, which has particular significance for confined explosives. Recent experimental work at the University of Sheffield, along with a small number of previous studies, has shown that some afterburn occurs at timescales commensurate with the development of the shock wave. This article presents the results from a series of tests measuring the reflected pressure acting on a rigid target following the detonation of small explosive charges. High-speed video is used to capture the emerging structure of the detonation products and air shock, while the spatial and temporal distributions of the reflected pressure are recorded using an array of 17 Hopkinson pressure bars set flush with an effectively rigid target. Tests are conducted in inert atmospheres and oxygen-rich atmospheres in order to assess the contribution of rapid afterburn on the development of the shock front and interaction with a rigid target situated close to the explosive charge. The results show that early-stage afterburn has a significant influence on the reflected shock parameters in the near-field

Predicting the response of plates subjected to near-field explosions using an energy equivalent impulse

Recent experimental work by the current authors has provided highly spatially and temporally resolved measurements of the loading imparted to, and the subsequent dynamic response of, structures subjected to near-field explosive loading [1]. In this article we validate finite element models of plates subjected to near-field blast loads and perform a parametric study into the relationship between imparted load and peak and residual plate deformation. The energy equivalent impulse is derived, based on the theory of upper bound kinetic energy uptake introduced herein, which accounts for the additional energy imparted to a structure from a spatially non-uniform blast load. Whilst plate deflection is weakly correlated to total impulse, there is shown to be a strong positive correlation between deflection and energy equivalent impulse. The strength of this correlation is insensitive to loading distribution and mode of response. The method developed in this article has clear applications for the generation of fast-running engineering tools for the prediction of structural response to near-field explosions

Women’s views on the impact of operative delivery in the second stage of labour: Qualitative interview study

Objective: To obtain the views of women on the impact of operative delivery in the second stage of labour. Design: Qualitative interview study. Setting: Two urban teaching hospitals in the United Kingdom. Participants: Purposive sample of 27 women who had undergone operative delivery in the second stage of labour between January 2000 and January 2002. Key themes: Preparation for birth, understandings of the indications for operative delivery, and explanation or debriefing after birth. Results: The women felt unprepared for operative delivery and thought that their birth plan or antenatal classes had not catered adequately for this event. They emphasised the importance of maintaining an open mind about the management of labour. They had difficulty understanding the need for operative delivery despite a review by medical and midwifery staff before discharge. Operative delivery had a noticeable impact on women's views about future pregnancy and delivery. Conclusions: Women consider postnatal debriefing and medical review important deficiencies in current care. Those who experienced operative delivery in the second stage of labour would welcome the opportunity to have a later review of their intrapartum care, physical recovery, and management of future pregnancies

Doppler-Free Spectroscopy of Weak Transitions: An Analytical Model Applied to Formaldehyde

Experimental observation of Doppler-free signals for weak transitions can be greatly facilitated by an estimate for their expected amplitudes. We derive an analytical model which allows the Doppler-free amplitude to be estimated for small Doppler-free signals. Application of this model to formaldehyde allows the amplitude of experimentally observed Doppler-free signals to be reproduced to within the experimental error.Comment: 7 pages, 7 figures, 1 table, v2: many small improvements + corrected line assignmen

Finite element simulation of plates under non-uniform blast loads using a point-load method: Buried explosives

There are two primary challenges associated with assessing the adequacy of a protective structure to resist explosive events: firstly the spatial variation of load acting on a target must be predicted to a sufficient level of accuracy; secondly, the response of the target to this load must also be quantified. When a high explosive is shallowly buried in soil, the added confinement given by the geotechnical material results in a blast which is predominantly directed vertically. This imparts an extremely high magnitude, spatially non-uniform load on the target structure. A recently commissioned experimental rig designed by the authors has enabled direct measurements of the blast load resulting from buried explosive events. These direct measurements have been processed using an in-house interpolation routine which evaluates the load acting over a regular grid of points. These loads can then be applied as the nodal-point loads in a finite element model. This paper presents results from a series of experiments where a free-flying plate was suspended above a shallow buried explosive. Dynamic and residual deformations are compared with finite element simulations of plates using the experimentally recorded, and interpolated, nodal point-loads. The results show very good agreement and highlight the use of this method for evaluating the efficacy of targets subjected to non-uniform blast loads

Predicting specific impulse distributions for spherical explosives in the extreme near-field using a Gaussian function

Accurate quantification of the blast load arising from detonation of a high explosive has applications in transport security, infrastructure assessment and defence. In order to design efficient and safe protective systems in such aggressive environments, it is of critical importance to understand the magnitude and distribution of loading on a structural component located close to an explosive charge. In particular, peak specific impulse is the primary parameter that governs structural deformation under short-duration loading. Within this so-called extreme near-field region, existing semi-empirical methods are known to be inaccurate, and high-fidelity numerical schemes are generally hampered by a lack of available experimental validation data. As such, the blast protection community is not currently equipped with a satisfactory fast-running tool for load prediction in the near-field. In this article, a validated computational model is used to develop a suite of numerical near-field blast load distributions, which are shown to follow a similar normalised shape. This forms the basis of the data-driven predictive model developed herein: a Gaussian function is fit to the normalised loading distributions, and a power law is used to calculate the magnitude of the curve according to established scaling laws. The predictive method is rigorously assessed against the existing numerical dataset, and is validated against new test models and available experimental data. High levels of agreement are demonstrated throughout, with typical variations of <5% between experiment/model and prediction. The new approach presented in this article allows the analyst to rapidly compute the distribution of specific impulse across the loaded face of a wide range of target sizes and near-field scaled distances and provides a benchmark for data-driven modelling approaches to capture blast loading phenomena in more complex scenarios

Heterozygous mutations in HSD17B4 cause juvenile peroxisomal D-bifunctional protein deficiency

Objective: To determine the genetic cause of slowly progressive cerebellar ataxia, sensorineural deafness, and hypergonadotropic hypogonadism in 5 patients from 3 different families. Methods: The patients comprised 2 sib pairs and 1 sporadic patient. Clinical assessment included history, physical examination, and brain MRI. Linkage analysis was performed separately on the 2 sets of sib pairs using single nucleotide polymorphism microarrays, followed by analysis of the intersection of the regions. Exome sequencing was performed on 1 affected patient with variant filtering and prioritization undertaken using these intersected regions. Results: Using a combination of sequencing technologies, we identified compound heterozygous mutations in HSD17B4 in all 5 affected patients. In all 3 families, peroxisomal D-bifunctional protein (DBP) deficiency was caused by compound heterozygosity for 1 nonsense/deletion mutation and 1 missense mutation. Conclusions: We describe 5 patients with juvenile DBP deficiency from 3 different families, bringing the total number of reported patients to 14, from 8 families. This report broadens and consolidates the phenotype associated with juvenile DBP deficiency

Complete callosal agenesis, pontocerebellar hypoplasia, and axonal neuropathy due to AMPD2 loss

Objective: To determine the molecular basis of a severe neurologic disorder in a large consanguineous family with complete agenesis of the corpus callosum (ACC), pontocerebellar hypoplasia (PCH), and peripheral axonal neuropathy. Methods: Assessment included clinical evaluation, neuroimaging, and nerve conduction studies (NCSs). Linkage analysis used genotypes from 7 family members, and the exome of 3 affected siblings was sequenced. Molecular analyses used Sanger sequencing to perform segregation studies and cohort analysis and Western blot of patient-derived cells. Results: Affected family members presented with postnatal microcephaly and profound developmental delay, with early death in 3. Neuroimaging, including a fetal MRI at 30 weeks, showed complete ACC and PCH. Clinical evaluation showed areflexia, and NCSs revealed a severe axonal neuropathy in the 2 individuals available for electrophysiologic study. A novel homozygous stopgain mutation in adenosine monophosphate deaminase 2 (AMPD2) was identified within the linkage region on chromosome 1. Molecular analyses confirmed that the mutation segregated with disease and resulted in the loss of AMPD2. Subsequent screening of a cohort of 42 unrelated individuals with related imaging phenotypes did not reveal additional AMPD2 mutations. Conclusions: We describe a family with a novel stopgain mutation in AMPD2. We expand the phenotype recently described as PCH type 9 to include progressive postnatal microcephaly, complete ACC, and peripheral axonal neuropathy. Screening of additional individuals with related imaging phenotypes failed to identify mutations in AMPD2, suggesting that AMPD2 mutations are not a common cause of combined callosal and pontocerebellar defects

Far-field positive phase blast parameter characterisation of RDX and PETN based explosives

A significant amount of scientific effort has been dedicated to measuring and understanding the effects of explosions, leading to the development of semi-empirical methods for rapid prediction of blast load parameters. The most well-known of these, termed the Kingery and Bulmash method, makes use of polylogarithmic curves derived from a compilation of medium to large scale experimental tests performed over many decades. However, there is still no general consensus on the accuracy and validity of this approach, despite some researchers reporting consistently high levels of agreement. Further, it is still not known whether blast loading can be considered deterministic, or whether it is intrinsically variable, the extent of this variability, and the range and scales over which these variations are observed. This article critically reviews historic and contemporary blast experiments, including newly generated arena tests with RDX and PETN-based explosives, with a view to demonstrating the accuracy with which blast load parameters can be predicted using semi-empirical approaches