The key to employability: developing a practical model of graduate employability

Purpose – The purpose of this paper is to introduce a straightforward, practical model of employability that will allow the concept to be explained easily and that can be used as a framework for working with students to develop their employability. Design/methodology/approach – The model was developed from existing research into employability issues and the experience of the authors. The various elements of employability included in the model are discussed and their inclusion justified on the basis of existing research. Findings – The model sets out exactly what is meant by employability, in clear and simple terms, and the model suggests directions for interaction between the various elements. Research limitations/implications – The relationships between and the interaction of the elements within the model remain theoretical. Further research to test the model is planned and will be reported on at a later date. Practical implications – The model can be used to explain the concept of employability to those new to the subject, and particularly to students and their parents. It will be a useful tool for lecturers, personal tutors, careers advisors and any other practitioners involved in employability activities. It will also be used to develop a measurement tool for employability. Originality/value – This paper seeks to fill the gap between in-depth, scholarly and complex articles or books about employability and very simple descriptive articles. It will be of value to anybody with an interest in employability issues

Moving from conceptual ambiguity to operational clarity: Employability, enterprise and entrepreneurship in higher education

Purpose – The purpose of this paper is to discuss how the terms “employability”, “enterprise” and “entrepreneurship” are currently being used, often interchangeably, within higher education, and to propose how to clarify this issue with the terminology. Design/methodology/approach – The approach taken is to discuss the three terms and some of their current conceptualisations and suggest ways to clarify the terminology. Possible methods of operationalising the three concepts within higher education are also suggested. Findings – Employability, enterprise and entrepreneurship are high on the agendas of many higher education institutions. There is a crucial need for agreement on definitions particularly when strategies are being implemented. It is suggested that currently the terminology is often used carelessly and interchangeably, resulting in confusion for HE staff, students and employers. Originality/value – The paper offers a clear way of defining the concepts and will be of value to anybody with an interest in employability, enterprise or entrepreneurship within higher education

An integrated mathematical model of cellular cholesterol biosynthesis and lipoprotein metabolism

Cholesterol regulation is an important aspect of human health. In this work we bring together and extend two recent mathematical models describing cholesterol biosynthesis and lipoprotein endocytosis to create an integrated model of lipoprotein metabolism in the context of a single hepatocyte. The integrated model includes a description of low density lipoprotein (LDL) receptor and cholesterol synthesis, delipidation of very low density lipoproteins (VLDLs) to LDLs and subsequent lipoprotein endocytosis. Model analysis shows that cholesterol biosynthesis produces the majority of intracellular cholesterol. The availability of free receptors does not greatly effect the concentration of intracellular cholesterol, but has a detrimental effect on extracellular VLDL and LDL levels. We test our model by considering its ability to reproduce the known biology of Familial Hypercholesterolaemia and statin therapy. In each case the model reproduces the known biological behaviour. Quantitative differences in response to statin therapy are discussed in the context of the need to extend the work to a more {\it in vivo} setting via the incorporation of more dietary lipoprotein related processes and the need for further testing and parameterisation of {\it in silico} models of lipoprotein metabolism

Reninoma: an uncommon cause of renin-mediated hypertension

Reninoma (juxtaglomerular cell tumor) is a rare cause of renin-mediated hypertension. Reninomas are usually diagnosed in adolescents and young adults with occasional reports in younger children. Patients typically present with a long history of headaches leading to a diagnosis of severe hypertension that responds well to antihypertensive treatment targeting the renin-angiotensin-aldosterone system. The clue to clinical diagnosis is the presence of hypokalemia and metabolic alkalosis on the first blood sample drawn before any treatment is instituted. Elevated blood levels of renin and aldosterone confirm the clinical suspicion of renin-mediated hypertension. Diagnostic imaging is employed to identify the source of excessive renin production. While renal ultrasound can miss reninoma, contrast CT or magnetic resonance imaging of the kidneys are diagnostic modalities of choice leading to the correct diagnosis. Renal vein renin sampling with lateralization might help to identify the site of excessive renin production. Nephron-sparing surgery is curative with maintenance of normal blood pressure after discontinuation of antihypertensive medications in the majority of patients. In this paper, we present the case of reninoma in an adolescent girl emphasizing clinical presentation, diagnostic evaluation, and medical and surgical treatment of this rare tumor. We also discuss important points in the management of children presenting with renin-mediated hypertension

Dual Extended Kalman Filter for the Identification of Time-Varying Human Manual Control Behavior

A Dual Extended Kalman Filter was implemented for the identification of time-varying human manual control behavior. Two filters that run concurrently were used, a state filter that estimates the equalization dynamics, and a parameter filter that estimates the neuromuscular parameters and time delay. Time-varying parameters were modeled as a random walk. The filter successfully estimated time-varying human control behavior in both simulated and experimental data. Simple guidelines are proposed for the tuning of the process and measurement covariance matrices and the initial parameter estimates. The tuning was performed on simulation data, and when applied on experimental data, only an increase in measurement process noise power was required in order for the filter to converge and estimate all parameters. A sensitivity analysis to initial parameter estimates showed that the filter is more sensitive to poor initial choices of neuromuscular parameters than equalization parameters, and bad choices for initial parameters can result in divergence, slow convergence, or parameter estimates that do not have a real physical interpretation. The promising results when applied to experimental data, together with its simple tuning and low dimension of the state-space, make the use of the Dual Extended Kalman Filter a viable option for identifying time-varying human control parameters in manual tracking tasks, which could be used in real-time human state monitoring and adaptive human-vehicle haptic interfaces

Resolving the Centipede’s Dilemma: external focus distance and expertise in applied, continuous skills

Research has reliably demonstrated that an external focus of attention during skill production enhances performance, retention, and transfer relative to an internal focus on movement mechanics. The optimisation of external focus points, across a range of contexts and performers, is important for effective skill production. Two studies were conducted evaluating the impact of external focus distance in an applied, continuous sports skill (kayak sprinting) with participants of two different expertise levels. In Study 1, using a within-participants design, recreational kayakers (n = 20) were timed sprinting 75 m in a surf ski under proximal external focus, distal external focus, and control conditions. The distal focus (on the finish) (29.75 s) was significantly faster than both other trials (ps < 0.001). The control condition (30.95 s) was significantly faster than the proximal focus (on the boat) (32.37 s) (p = 0.003). The effect size was large (ηp2 = 0.55). In Study 2, specifically trained racers in sprint kayaks (K1s) (n = 16) were timed in a 100 m K1 sprint under the same three conditions as in Study 1. The control condition (28.96 s) was significantly faster than the proximal focus trial (29.83 s) (p = 0.02). The effect size was large (ηp2 = 0.23). There was no significant difference between the distal focus trial (29.03 s) and the other conditions. These findings suggest that focus distance can play a pivotal role in continuous skills. Whilst recreational performers may benefit immediately from a distal focus, this might not be the case for specifically trained athletes. Further, a proximal focus on fitted, passive equipment may be detrimental to performance

Community response to intermittent preventive treatment of malaria in infants (IPTi) in Papua New Guinea

<p>Abstract</p> <p>Background</p> <p>Building on previous acceptability research undertaken in sub-Saharan Africa this article aims to investigate the acceptability of intermittent preventive treatment of malaria in infants (IPTi) in Papua New Guinea (PNG).</p> <p>Methods</p> <p>A questionnaire was administered to mothers whose infants participated in the randomised placebo controlled trial of IPTi. Mothers whose infants participated and who refused to participate in the trial, health workers, community reporters and opinion leaders were interviewed. Men and women from the local community also participated in focus group discussions.</p> <p>Results</p> <p>Respondents viewed IPTi as acceptable in light of wider concern for infant health and the advantages of trial participation. Mothers reported complying with at-home administration of IPTi due to perceived benefits of IPTi and pressure from health workers. In spite of patchy knowledge, respondents also demonstrated a demand for infant vaccinations and considered non-vaccination to be neglect. There is little evidence that IPTi has negative impacts on attitudes to EPI, EPI adherence or existing malaria prevention practices.</p> <p>Conclusion</p> <p>The degree of similarity between findings from the acceptability studies undertaken in sub-Saharan Africa and PNG allows some generalization relating to the implementation of IPTi outside of Africa: IPTi fits well with local health cultures, appears to be accepted easily and has little impact on attitudes towards EPI or malaria prevention. The study adds to the evidence indicating that IPTi could be rolled out in a range of social and cultural contexts.</p