Predictive maintenance of bearing machinery using simulation- a bibliometric study

Modelling is a way of constructing a virtual representation of software and hardware that involves a real-world device. We will discover the behaviour of the system if the software elements of this model are guided by mathematical relationships. For testing conditions that may be difficult to replicate with hardware prototypes alone, modelling and simulation are particularly useful, especially in the early phase of the design process when hardware might not be available. Model-based approach in MATLAB-Simulink can be useful for predictive maintenance of machines as it can reduce unplanned downtimes and maintenance costs when industrial equipment breaks. Through this bibliometric paper, we carefully investigated the previously done research with the help of a number of papers from the Scopus Database. An overall analysis of the papers has been carried out to identify the extent of research done in this domain and understand the nature of the research work carried out considering the evolution of various predictive maintenance strategies being developed in recent years

FORMULATION AND EVALUATION OF LAMOTRIGINE BASED SELF-NANO EMULSIFYING DRUG DELIVERY SYSTEM

Self-nanoemulsionof Lamotrigine (LMT), an anti-epileptic agent, having poor solubilty was formulated to improve the solubility and permeation. Co surfactant like Ethyl Oleate, Caprylate, Eucalyptus oil, Caprylic, Corn oil, Capmule, Fish oil, Coconut oil whereas PEG 400 and Propylene glycol to form the oil phase was selected as the oil. Seven trials were done using combination of sufactants/co-surfactants with oil phase . Trial H containing Caprylate as oil phase at Smix1:1(Tween20/PEG400, 1:1) proportion and trial I, the oil phase [Caprylate] composition was changed from Smix 1:1 to Smix (Tween20/PEG400, 1:2) formulated as SNEDDs and phase diagram shows 1:1 system is suitable for formulation . Aqueous dilution test shows that it is found for 3 hour gradually turbid on staying. Since it immediately dissolve the drug as a result of solubilisation effect of surfactant present in formulation. Stability study was carried out at 25o C/ 75 Rh. In this method no change in consistency, Colour or appearance has been observed. In vitro drug release was found to be identical in the formulations stored before after placed on stability. It appeared that the formulation of the selected batches kept on the stability test was found to be stable. In accelerated stability evaluation showed that Self nano-emulsion follows 1st order kinetic and found to be stabl

A method for detergent-free isolation of membrane proteins in their local lipid environment.

Despite the great importance of membrane proteins, structural and functional studies of these proteins present major challenges. A significant hurdle is the extraction of the functional protein from its natural lipid membrane. Traditionally achieved with detergents, purification procedures can be costly and time consuming. A critical flaw with detergent approaches is the removal of the protein from the native lipid environment required to maintain functionally stable protein. This protocol describes the preparation of styrene maleic acid (SMA) co-polymer to extract membrane proteins from prokaryotic and eukaryotic expression systems. Successful isolation of membrane proteins into SMA lipid particles (SMALPs) allows the proteins to remain with native lipid, surrounded by SMA. We detail procedures for obtaining 25 g of SMA (4 d); explain the preparation of protein-containing SMALPs using membranes isolated from Escherichia coli (2 d) and control protein-free SMALPS using E. coli polar lipid extract (1-2 h); investigate SMALP protein purity by SDS-PAGE analysis and estimate protein concentration (4 h); and detail biophysical methods such as circular dichroism (CD) spectroscopy and sedimentation velocity analytical ultracentrifugation (svAUC) to undertake initial structural studies to characterize SMALPs (∼2 d). Together, these methods provide a practical tool kit for those wanting to use SMALPs to study membrane proteins

Spontaneous inferior vena cava dissection and aneurysm with ilio-caval fistula

A case of spontaneous inferior vena cava dissection and aneurysm with ilio caval fistula in a 40 years male presenting with complaints of pain and swelling in right illiac fossa and swelling of right leg with no history of trauma is reported. The diagnosis was based upon the ultrasound, Doppler and contrast CT findings with clinical profile

Electrical and optical characterization of DBD based XeCl UV excimer source

In recent decades, interest in development of novel UV/VUV sources with spontaneous emission has grown 1 . Among the all UV/VUV sources, excimers occupy major attention due to the many characteristics, such as, technological features, design, the service life, the cost, etc. In all types of known excimer sources, Dielectric Barrier Discharge (DBD) is most effective and low cost technique 2 . In this work a DBD based XeCl UV excimer source has been developed. In the developed volume discharge (VD) configuration of DBD source, the temporal behaviour of the electrical quantities of the discharge has been obtained using an equivalent electrical circuit model 3 to electrically characterize the developed source. Furthermore, to identify the dependency on diffusion process an emission spectroscopy analysis is also performed. The source is a single barrier DBD filled with binary mixture of xenon and chlorine gases. A unipolar pulse-like waveform has been used to excite the discharge. Based on the electrical and spectroscopy analysis, the discharge parameters are obtained which has been optimized to improve the radiation efficiency of the rare gas monohalide XeCl* (308nm) from this source. This particular spectral line is highly applicable for skin treatment. The nonexistence of the mercury in the excilamps is the creditable to cite and the DBD based excilamps are giving the competition to the mercury filled lamps which are ecological insecure for the human health

Adverse effects & drug load of antiepileptic drugs in patients with epilepsy: Monotherapy versus polytherapy

Background & objectives: Although the need for a combination of antiepileptic drugs (AEDs) in the treatment of epilepsy is well justified, but an associated increase in adverse effects (AEs) lends a restriction to polytherapy. The aim of this study was to evaluate AEs and drug load (prescribed daily dose/defined daily doses) of AEDs in patients with epilepsy (PWE). Methods: Consecutive PWEs attending Epilepsy clinic in a tertiary care hospital in New Delhi, India, were enrolled in the study. Demographic variables, such as age, gender, diagnosis, age at onset of seizures, frequency of seizures, use of all AEDs and adverse event profile (AEP) score were noted. Routine laboratory tests including lipid profile, fasting blood glucose, haematological parameters and liver and kidney function tests were done. Results: A total of 697 consecutive patients were included in this study. Of them, 64.4 per cent were male; mean age was 29.6 ± 10.6 yr. Generalized seizures and focal seizures were recorded in n=386 (55.4%) and n=311 (44.6%), respectively. Monotherapy and polytherapy with two and greater than or equal to three AEDs were prescribed in 264 (37.9%), 243 (34.9%) and 190 (27.2%) patients, respectively. The average AED load, duration of treatment as well as AEP score were found to be significantly higher in combination of greater than or equal to three AEDs as compared to both monotherapy and combination of two AEDs, whereas no significant difference was observed between monotherapy and combination of two AEDs. Patients on monotherapy were in good control of seizures as compared to polytherapy. There was no significant change in biochemical parameters between the groups. Interpretation & conclusions: Polytherapy with combination of greater than or equal to three AEDs was associated with higher AEs and lower seizure control as compared to both monotherapy and combination of two AEDs. AEs did not correlate with AED load, seizure type, gender and age of the patients but were associated with both numbers of AEDs as well as seizure frequency in PWE

Intrathecal Drug Delivery Systems Survey: Trends in Utilization in Pain Practice

Background: The use of intrathecal drug delivery for chronic and cancer pain medicine has been established for decades. However, optimization and utilization of this technique still lag behind other modalities for pain control. Some of this may be due to variability of surgical technique, medication usage and education. It is currently unclear on whether or not practitioners follow available algorithms for the use of intrathecal drug delivery systems. Methods: A survey developed by the American Society of Pain and Neuroscience (ASPN) was sent to its members via email using the cloud-based . After 30 days of being available, 159 different providers responded to the survey that consisted of 31 various multiple choice and free response questions. Each question was not required and the number of responses to each varied from 128 to 159. Results: Approximately 9% of those who successfully received and opened the email containing the survey responded, likely due to a small number of providers working with intrathecal drug delivery systems. Eighty-six of respondents practice medicine in the United States, and 87% of the respondents were attending physicians. A majority of respondents, approximately 74%, were board certified in pain medicine with 69% of respondents being train in anesthesiology. The first and second most used medications for intrathecal pump trial were morphine and fentanyl, respectively. Most respondents, approximately 96%, provide pre-operative/intra-operative antibiotics. The most common first-choice medication for implanted intrathecal pumps was also morphine with the most common implanted location being the abdomen. Conclusion: Interestingly, there is currently fairly substantial variation in the way providers utilize intrathecal pump delivery for both chronic and cancer pain. There is variation from the training background of the providers providing care, to the pre-implantation trial medications, to where the pump is implanted for each patient, to if the patient has the option to give themselves boluses once implanted. Further research is needed to elucidate current and best practices for intrathecal drug delivery system trials, implantations, and utilization

Transplant Glomerulopathy in the Absence of Donor Specific Antibodies

Conclusions: Half of our 50 patients with TG documented by EM had no DSAs or positive C4d staining in PTCs. Almost 70% of the patients evidenced PTC basement membrane multilayering. These patients were all diagnosed with chronic active CMR independently of the presence of TG. Cellular rejection mechanisms are likely the cause of the TG in this group. Patients with TG and DSAs are at greater risk for episodes of acute AMR and CMR. C4d staining of PTCs was evident in less than 40% and in the glomeruli in less than half. Interestingly, 25 of the 26 DSA+ patients were independently diagnosed with chronic active CMR