Actual problems of education of children in educational institution

The article describes the current problems of children`s education in general educational institutions. We consider the problem of poor awareness among parents, maintain and enhance the quality of education, the problem of moral education of children, the impossibility of applying an individual approach to the student, the problem of efficiency of the educational systemВ статье раскрываются актуальные проблемы воспитания детей в общеобразовательных учреждениях. Рассматриваются проблемы низкой информированности родителей, сохранения и повышения качества образования, проблемы нравственного воспитания детей, проблемы невозможности применения индивидуального подхода к ученику, проблемы эффективности системы воспитани

Classification of double flag varieties of complexity 0 and 1

A classification of double flag varieties of complexity 0 and 1 is obtained. An application of this problem to decomposing tensor products of irreducible representations of semisimple Lie groups is considered

Domain evolution of BaTiO3 ultrathin films under electric field: a first-principles study

A first-principles-derived method is used to study the morphology and electric-field-induced evolution of stripe nanodomains in (001) BaTiO3 (BTO) ultrathin films, and to compare them with those in (001) Pb(Zr,Ti)O3 (PZT) ultrathin films. The BaTiO3 systems exhibit 180o periodic stripe domains at null electric field, as in PZT ultrathin films. However, the stripes alternate along [1-10] in BTO systems versus [010] in PZT systems, and no in-plane surface dipoles occur in BTO ultrathin films (unlike in PZT materials). Moreover, the evolution of the 180o stripe domains in the BaTiO3 systems, when applying and increasing an electric field along [001], involves four regions: Region I for which the magnitude of the down dipoles (i.e., those that are antiparallel to the electric field) is reduced, while the domain walls do not move; Region II in which some local down dipoles adjacent to domain walls switch their direction, resulting in zigzagged domain walls - with the overall stripe periodicity being unchanged; Region III in which nanobubbles are created, then contract along [110] and finally collapse; and Region IV which is associated with a single monodomain. Such evolution differs from that of PZT ultrathin films for which neither Region I nor zigzagged domain walls exist, and for which the bubbles contract along [100]. Discussion about such differences is provided.Comment: 19 pages, 4 figures, 27 references, submitted to Phys. Rev.

Low carbon global economy: Scenarios of sustainable development, power consumption and greenhouse gas emission control

This paper is devoted to problems of a gradual transfer to renewable energy sources and decarbonization of power systems. It presents the analysis of the structure and the trend in global power consumption, greenhouse gas emissions, and target values of decreased emissions by the largest greenhouse gas emitters. A trend in renewable energy sources in total global power consumption is analyzed. The authors study a potential for carbon capture and storage as an instrument of CO2 emission neutralization in power and industrial processes. The paper contains indicators to evaluate efficiency of power resource utilization and greenhouse gas emission control. © 2019 IOP Publishing Ltd. All rights reserved

Intracellular origin and ultrastructure of platelet-derived microparticles

© 2017 International Society on Thrombosis and Haemostasis Essentials Platelet microparticles play a major role in pathologies, including hemostasis and thrombosis. Platelet microparticles have been analyzed and classified based on their ultrastructure. The structure and intracellular origin of microparticles depend on the cell-activating stimulus. Thrombin-treated platelets fall apart and form microparticles that contain cellular organelles. Summary: Background Platelet-derived microparticles comprise the major population of circulating blood microparticles that play an important role in hemostasis and thrombosis. Despite numerous studies on the (patho)physiological roles of platelet-derived microparticles, mechanisms of their formation and structural details remain largely unknown. Objectives Here we studied the formation, ultrastructure and composition of platelet-derived microparticles from isolated human platelets, either quiescent or stimulated with one of the following activators: arachidonic acid, ADP, collagen, thrombin or calcium ionophore A23187. Methods Using flow cytometry, transmission and scanning electron microscopy, we analyzed the intracellular origin, structural diversity and size distributions of the subcellular particles released from platelets. Results The structure, dimensions and intracellular origin of microparticles depend on the cell-activating stimulus. The main structural groups include a vesicle surrounded by one thin membrane or multivesicular structures. Thrombin, unlike other stimuli, induced formation of microparticles not only from the platelet plasma membrane and cytoplasm but also from intracellular structures. A fraction of these vesicular particles having an intracellular origin contained organelles, such as mitochondria, glycogen granules and vacuoles. The size of platelet-derived microparticles depended on the nature of the cell-activating stimulus. Conclusion The results obtained provide a structural basis for the qualitative differences of various platelet activators, for specific physiological and pathological effects of microparticles, and for development of advanced assays

Structure and Specificity of a Permissive Bacterial C-Prenyltransferase

This study highlights the biochemical and structural characterization of the L-tryptophan C6 C-prenyltransferase (C-PT) PriB from Streptomyces sp. RM-5-8. PriB was found to be uniquely permissive to a diverse array of prenyl donors and acceptors including daptomycin. Two additional PTs also produced novel prenylated daptomycins with improved antibacterial activities over the parent drug

Integral assessment of the competitiveness of pharmacy organizations in the local market

This article describes the assessment of the competitiveness of pharmacy organizations in the local market in terms of various indicators.В данной статье рассмотрена оценка конкурентоспособности аптечных организаций на локальном рынке с точки зрения разных показателей