A Drug Dosage Table is a Useful Tool to Facilitate Prescriptions of Antiretroviral Drugs for Children in Thailand.

Scaling up of antiretroviral treatment (ART) for children in countries like Thailand will require decentralization and management by non-specialist doctors. We describe (a) the formulation of a standardized drug dosage table to facilitate antiretroviral drug (ARV) prescriptions for children, (b) the acceptability of such a table among doctors and (c) the safety and efficacy of drug doses in the table. Acceptability was assessed using a questionnaire. Safety and efficacy were assessed on the basis of incidence of adverse effects and virological response to treatment, respectively. Of all doctors (n=18), 17 (94%) found that the table was practical to use, avoided miscalculations and made them more confident with prescriptions. Of 49 children prescribed ARVs, less than 5% had adverse side-effects. All ARV-naïve children achieved undetectable viral loads within six months of ART. In our setting, a standardized drug dosage table provided a simple and reliable tool that facilitated ARV prescriptions for children

What We Think We Know About Cybersecurity: An Investigation of the Relationship between Perceived Knowledge, Internet Trust, and Protection Motivation in a Cybercrime Context

Individual internet users are commonly considered the weakest links in the cybersecurity chain. One reason for this is that they tend to be overoptimistic regarding their own online safety. To gain a better understanding of the cognitive processes involved in this assessment, the current study applies an extended version of the protection motivation theory. More specifically, this study includes perceived knowledge and internet trust to discover how these antecedents influence the threat and coping appraisal processes. Based on representative survey data collected from 967 respondents, we found that people who feel well-informed about online safety feel less vulnerable to cybercrime and are less inclined to take security measures. At the same time, feeling informed is associated with being more convinced of the severity of cybercrime. High levels of trust in the safety of the internet are linked to the feeling that one is less vulnerable to cybercrime and the perception that cybercrime is not a severe threat. Future interventions should remind internet users about their own perceived vulnerability and the risks that exist online while ensuring that internet users do not lose their trust in the internet and confidence in their own online knowledge

Intention to Hack? Applying the Theory of Planned Behaviour to Youth Criminal Hacking

Adolescents are currently the most digitally connected generation in history. There is an ever-growing need to understand how typical adolescent risk-taking intersects with the vastly criminogenic potential of digital technology. Criminal hacking in older adolescents (16–19-year-olds) was assessed using an adapted Theory of Planned Behaviour (TPB) model, a cohesive theoretical framework that incorporates cognitive processes and human drivers (informed by psychology, cyberpsychology, and criminology theory). In 2021, a large-scale anonymous online survey was conducted across nine European countries. Criminal hacking was assessed using data from 3985 participants (M = 1895, 47.55%; F = 1968, 49.39%). This study formulated a powerful predictive model of youth hacking intention (accounting for 38.8% of the variance) and behaviour (accounting for 33.6% of the variance). A significant minority, approximately one in six (16.34%), were found to have engaged in hacking, and approximately 2% reported engaging in hacking often or very often. Increased age, being male, and offline deviant behaviour were significant predictors of hacking behaviour. In line with the TPB, intention was the strongest individual predictor of hacking behaviour, which in turn was significantly predicted by cognitive processes accounted for by TPB constructs: subjective norms of family and peers, attitudes towards hacking, and perceived behavioural control. These TPB constructs were found to be significantly associated with human factors of risk-taking, toxic online disinhibition, offline deviant behaviour, and demographic variables of age and gender. Implications for future research, interventions, policy, and practice are discussed

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Measuring Reciprocity in High Functioning Children and Adolescents with Autism Spectrum Disorders

Few instruments have been developed that measure impairments in reciprocity, a defining feature of autism. We introduce a new test assessing the quality of reciprocal behaviour: the interactive drawing test (IDT). Children and adolescents (n = 49) with and without high functioning autism spectrum disorders (HFASD) were invited to collaborate with an experimenter in making a joint drawing. Within both groups the performance on collaborative reciprocity improved with age. However, compared to the control group, HFASD participants showed less collaborative and more basic reciprocal behaviour and preferred to draw their own objects. They were less tolerant of the experimenter’s input as well. Performance on the IDT was independent of estimated verbal IQ. Reciprocal behaviour in self-initiated objects corresponded with more parental reported autistic traits, while reciprocal behaviour in other-initiated objects corresponded with less autistic traits. The findings of this study suggest that IDT is a promising instrument to assess reciprocity

Bouncing back : the wellbeing of children in international child abduction cases

This report contains the results of a three-part research project conducted in the framework of the project Enhancing the Well-being of Children in Cases of International Child Abduction (eWELL). Part I contains an overview of the results of a quantitative survey conducted among parents who have been in a situation of international parental child abduction. The quantitative survey data collection was financed by the European Commission and was undertaken by the University of Antwerp in collaboration with Centrum IKO, CFPE-Enfant Disparus, Child Focus, the French Central Authority and Missing Children Europe (MCE, the European umbrella organization for missing children). Part II provides an overview of the qualitative interview results conducted with children who were taken by to another country by one parent without the consent of the other. The qualitative data collection was co-financed by the European Commission and undertaken by the University of Antwerp, Centrum IKO, Child Focus, CFPE-Enfant Disparus, and in collaboration with the French Central Authority and Missing Children Europe (MCE, the European umbrella organization for missing children). Part III examines international parental child abduction court rulings, jurisdictions and the application of Art. 13 (2) of the 1980 Hague Convention on the Civil Aspects of International Child Abduction in Belgium, France and the Netherlands. It discusses age and maturity attainment and assessment; the involvement of intermediaries; the definition of the child’s objections to return and other relevant matters

Success with antiretroviral treatment for children in Kigali, Rwanda: Experience with health center/nurse-based care

BACKGROUND: Although a number of studies have shown good results in treating children with antiretroviral drugs (ARVs) in hospital settings, there is limited published information on results in pediatric programs that are nurse-centered and based in health centers, in particular on the psychosocial aspects of care. METHODS: Program treatment and outcome data were reported from two government-run health centers that were supported by Médecins Sans Frontières (MSF) in Kigali, Rwanda between October 2003 and June 2007. Interviews were held with health center staff and MSF program records were reviewed to describe the organization of the program. Important aspects included adequate training and supervision of nurses to manage ARV treatment. The program also emphasized family-centered care addressing the psychosocial needs of both caregivers and children to encourage early diagnosis, good adherence and follow-up. RESULTS: A total of 315 children (< 15 years) were started on ARVs, at a median age of 7.2 years (range: 0.7-14.9). Sixty percent were in WHO clinical stage I/II, with a median CD4% of 14%. Eighty-nine percent (n = 281) started a stavudine-containing regimen, mainly using the adult fixed-dose combination. The median follow-up time after ARV initiation was 2 years (interquartile range 1.2-2.6). Eighty-four percent (n = 265) of children were still on treatment in the program. Thirty (9.5%) were transferred out, eight (2.6%) died and 12 (3.8%) were lost to follow-up. An important feature of the study was that viral loads were done at a median time period of 18 months after starting ARVs and were available for 87% of the children. Of the 174 samples, VL was < 400 copies/ml in 82.8% (n = 144). Two children were started on second-line ARVs. Treatment was changed due to toxicity for 26 children (8.3%), mainly related to nevirapine. CONCLUSION: This report suggests that providing ARVs to children in a health center/nurse-based program is both feasible and very effective. Adequate numbers and training of nursing staff and an emphasis on the psychosocial needs of caregivers and children have been key elements for the successful scaling-up of ARVs at this level of the health system

Who is accessing public-sector anti-retroviral treatment in the Free State, South Africa? An exploratory study of the first three years of programme implementation

<p>Abstract</p> <p>Background</p> <p>Although South Africa has the largest public-sector anti-retroviral treatment (ART) programme in the world, anti-retroviral coverage in adults was only 40.2% in 2008. However, longitudinal studies of who is accessing the South African public-sector ART programme are scarce. This study therefore had one main research question: who is accessing public-sector ART in the Free State Province, South Africa? The study aimed to extend the current literature by investigating, in a quantitative manner and using a longitudinal study design, the participants enrolled in the public-sector ART programme in the period 2004-2006 in the Free State Province of South Africa.</p> <p>Methods</p> <p>Differences in the demographic (age, sex, population group and marital status) socio-economic (education, income, neo-material indicators), geographic (travel costs, relocation for ART), and medical characteristics (CD4, viral load, time since first diagnosis, treatment status) among 912 patients enrolled in the Free State public-sector ART programme between 2004 and 2006 were assessed with one-way analysis of variance, Bonferroni post-hoc analysis, and cross tabulations with the chi square test.</p> <p>Results</p> <p>The patients accessing treatment tended to be female (71.1%) and unemployed (83.4%). However, although relatively poor, those most likely to access ART services were not the most impoverished patients. The proportion of female patients increased (<it>P </it>< 0.05) and their socio-economic situation improved between 2004 and 2006 (<it>P </it>< 0.05). The increasing mean transport cost (<it>P </it>< 0.05) to visit the facility is worrying, because this cost is an important barrier to ART uptake and adherence. Encouragingly, the study results revealed that the interval between the first HIV-positive diagnosis and ART initiation decreased steadily over time (<it>P </it>< 0.05). This was also reflected in the increasing baseline CD4 cell count at ART initiation (<it>P </it>< 0.05).</p> <p>Conclusions</p> <p>Our analysis showed significant changes in the demographic, socio-economic, geographic, and medical characteristics of the patients during the first three years of the programme. Knowledge of the characteristics of these patients can assist policy makers in developing measures to retain them in care. The information reported here can also be usefully applied to target patient groups that are currently not reached in the implementation of the ART programme.</p

Abilities to explicitly and implicitly infer intentions from actions in adults with autism spectrum disorder

Previous research suggests that Autism Spectrum Disorder (ASD) might be associated with impairments on implicit but not explicit mentalizing tasks. However, such comparisons are made difficult by the heterogeneity of stimuli and the techniques used to measure mentalizing capabilities. We tested the abilities of 34 individuals (17 with ASD) to derive intentions from others’ actions during both explicit and implicit tasks and tracked their eye-movements. Adults with ASD displayed explicit but not implicit mentalizing deficits. Adults with ASD displayed typical fixation patterns during both implicit and explicit tasks. These results illustrate an explicit mentalizing deficit in adults with ASD, which cannot be attributed to differences in fixation patterns