Sparse experimental design : an effective an efficient way discovering better genetic algorithm structures

The focus of this paper is the demonstration that sparse experimental design is a useful strategy for developing Genetic Algorithms. It is increasingly apparent from a number of reports and papers within a variety of different problem domains that the 'best' structure for a GA may be dependent upon the application. The GA structure is defined as both the types of operators and the parameters settings used during operation. The differences observed may be linked to the nature of the problem, the type of fitness function, or the depth or breadth of the problem under investigation. This paper demonstrates that advanced experimental design may be adopted to increase the understanding of the relationships between the GA structure and the problem domain, facilitating the selection of improved structures with a minimum of effort

Optimizing sustainable multimodal distribution networks in the context of carbonpricing, with a case study in the Thai sugar industry

Transportation is a major cause of energy consumption and emissions which can bereduced by optimizing routings and using alternative modes of transport. This paperrelates to the strategic design of multimodal transportation networks. It presents ageneral model of green vehicle routing problems that supports strategic decisionmakingby identifying optimal solutions and provides data on costs and emissions.Three general linear programming models were developed that optimize multimodaldistribution networks that could be applied in many industries. Model I evaluatescarbon emissions; model II assesses carbon emissions and capacity constraints; andmodel III establishes total costs including transportation, handling, storage, fuel andcarbon costs.Thailand is the third largest world sugar exporter in the world and is piloting carbonpricing, which will affect energy intensive industries, including the sugar industry. Themodels are applied using data obtained from a collaborating company. The researchcontributed to practice by informing managerial decisions relating to the export of sugarfrom the factory. This included evaluating the possible use of a dry port with railconnections, which could reduce transportation and carbon costs by 54.3% andfacilitate the building of another factory to increase exports

Zinc intake, status and indices of cognitive function in adults and children: a systematic review and meta-analysis

In developing countries, deficiencies of micronutrients are thought to have a major impact on child development; however, a consensus on the specific relationship between dietary zinc intake and cognitive function remains elusive. The aim of this systematic review was to examine the relationship between zinc intake, status and indices of cognitive function in children and adults. A systematic literature search was conducted using EMBASE, MEDLINE and Cochrane Library databases from inception to March 2014. Included studies were those that supplied zinc as supplements or measured dietary zinc intake. A meta-analysis of the extracted data was performed where sufficient data were available. Of all of the potentially relevant papers, 18 studies met the inclusion criteria, 12 of which were randomised controlled trials (RCTs; 11 in children and 1 in adults) and 6 were observational studies (2 in children and 4 in adults). Nine of the 18 studies reported a positive association between zinc intake or status with one or more measure of cognitive function. Meta-analysis of data from the adult’s studies was not possible because of limited number of studies. A meta-analysis of data from the six RCTs conducted in children revealed that there was no significant overall effect of zinc intake on any indices of cognitive function: intelligence, standard mean difference of <0.001 (95% confidence interval (CI) –0.12, 0.13) P=0.95; executive function, standard mean difference of 0.08 (95% CI, –0.06, 022) P=0.26; and motor skills standard mean difference of 0.11 (95% CI –0.17, 0.39) P=0.43. Heterogeneity in the study designs was a major limitation, hence only a small number (n=6) of studies could be included in the meta-analyses. Meta-analysis failed to show a significant effect of zinc supplementation on cognitive functioning in children though, taken as a whole, there were some small indicators of improvement on aspects of executive function and motor development following supplementation but high-quality RCTs are necessary to investigate this further

Th17 Cells Are Involved in the Local Control of Tumor Progression in Primary Intraocular Lymphoma

BACKGROUND: Th17 cells play an important role in the pathogenesis of many autoimmune diseases, but despite some reports of their antitumor properties, too little is known about their presence and role in cancers. Specifically, knowledge is sparse about the relation of Th17 to lymphoma microenvironments and, more particularly, to the microenvironment of primary intraocular B-cell lymphoma (PIOL), an aggressive lymphoma with a poor prognosis. METHODS AND PRINCIPAL FINDINGS: In this work, we investigated the presence of Th17 cells and their related cytokines in a syngeneic model of PIOL, a subtype of non-Hodgkin lymphoma. The very small number of lymphocytes trafficking in normal eyes, which represent a low background as compared to tumor-bearing eyes, allows us to develop the present model to characterize the different lymphocyte subsets present when a tumor is developing. IL-21 mRNA was expressed concomitantly with IL-17 mRNA in tumor-bearing eyes and intracellular expression of IL-17A and IL-21 in infiltrating CD4(+) T lymphocytes. Interestingly, IL-17A production by T cells was negatively correlated with tumor burden. We also showed that IL-21 but not IL-17 inhibits tumor cell proliferation in vitro. CONCLUSIONS: These data demonstrate that IL-17A and IL-21-producing CD4(+) T cells, referred as Th17 cells, infiltrate this tumor locally and suggest that Th17-related cytokines may counteract tumor progression via IL-21 production. Thus, Th17 cells or their related cytokines could be considered to be a new therapeutic approach for non-Hodgkin B-cell lymphomas, particularly those with an ocular localization

Applying different control approaches for resources with high and low utilisation: a case study of the production of complex products with stochastic processing times

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