Comitê de Ética em Pesquisas. Necessidade obrigatória. Obrigatoriedade necessária

Univ Pernambuco, Fac Ciencias Med, Disciplina Cirurgia Cardiotorac, Recife, PE, BrazilUniversidade Federal de São Paulo, São Paulo, BrazilUniversidade Federal de São Paulo, EPM, São Paulo, BrazilWeb of Scienc

The flood, the channels, and the dykes : managing legal information a globalized and digital world

Information search and retrieval are part of daily routines of the legal profession. Lawyers, judges, prosecutors, and legal clerks usually access a number of electronic resources to browse, search, select, or update legal contents. Legal databases have currently become large digital libraries where the tasks related to information-seeking may sometimes be cumbersome. Adding semantics to support information search may provide significant results in terms of efficiency, efficacy, and user satisfaction. Semantic technologies may be able to improve legal information search in the judicial and lawyers' domains. However, legal professionals sometimes prefer following routines than changing their information search behavior. New trends in legal ontologies and Semantic Web technologies may help to improve both professional and laymen's skills

ROOBY study: A critical view

Univ Pernambuco, Fac Ciencias Med, FCM UPE, Div Cirurgia Cardiovasc, Recife, PE, BrazilPronto Socorro Cardiol Pernambuco PROCAPE, Recife, PE, BrazilUniv Miami, CT Surg, Jackson Mem Hosp, Coral Gables, FL 33124 USAUniv Fed Sao Paulo, UNIFESP, Div Cirurgia Cardiovasc, Sao Paulo, BrazilUniv Fed Sao Paulo, UNIFESP, Div Cirurgia Cardiovasc, Sao Paulo, BrazilWeb of Scienc

Reasoning with multi-version ontologies: evaluation

Deliverable D3.5.2(WP3.5)In this document, we present an evaluation of the Multi-version Ontology Reasoning system MORE. The framework of MORE is developed based on a temporal logic approach. We take multiple versions of the legal ontology OPJK, one of the case studies in the SEKT project, as the test data set to test the prototype of the multi-version ontology reasoning system MORE, by which we investigate and evaluate the applicability of the system

Tricuspid valve intervention at the time of pulmonary valve replacement in adults with congenital heart disease: A systematic review and meta-analysis

Background Tricuspid regurgitation (TR) is a common finding in adults with congenital heart disease referred for pulmonary valve replacement (PVR). However, indications for combined valve surgery remain controversial. This study aimed to evaluate early results of concomitant tricuspid valve intervention (TVI) at the time of PVR. Methods and Results Observational studies comparing TVI+PVR and isolated PVR were identified by a systematic search of published research. Random-effects meta-analysis was performed, comparing outcomes between the 2 groups. Six studies involving 749 patients (TVI+PVR, 278 patients; PVR, 471 patients) met the eligibility criteria. In the pooled analysis, both TVI+PVR and PVR reduced TR grade, pulmonary regurgitation grade, right ventricular end-diastolic volume, and right ventricular end-systolic volumes. TVI+PVR, but not PVR, was associated with a decrease in tricuspid valve annulus size (mean difference, -6.43 mm, 95% CI, -10.59 to -2.27

Surgical aortic valve replacement and patient-prosthesis mismatch a meta-analysis of 108 182 patients

OBJECTIVES: This study sought to evaluate the impact of patient–prosthesis mismatch (PPM) on the risk of perioperative, early-, mid- and long-term mortality rates after surgical aortic valve replacement. METHODS: Databases were searched for studies published until March 2018. The main outcomes of interest were perioperative mortality, 1-year mortality, 5-year mortality and 10-year mortality. RESULTS: The search yielded 3761 studies for inclusion. Of these, 70 articles were analysed, and their data were extracted. The total num- ber of patients included was 108 182 who underwent surgical aortic valve replacement. The incidence of PPM after surgical aortic valve re- placement was 53.7% (58 116 with PPM and 50 066 without PPM). Perioperative mortality [odds ratio (OR) 1.491, 95% confidence interval (CI) 1.302–1.707; P < 0.001], 1-year mortality (OR 1.465, 95% CI 1.277–1.681; P < 0.001), 5-year mortality (OR 1.358, 95% CI 1.218–1.515; P < 0.001) and 10-year mortality (OR 1.534, 95% CI 1.290–1.825; P < 0.001) were increased in patients with PPM. Both severe PPM and moderate PPM were associated with increased risk of perioperative mortality, 1-year mortality, 5-year mortality and 10-year mortality when analysed together and separately, although we observed a higher risk in the group with severe PPM. CONCLUSIONS: Moderate/severe PPM increases perioperative, early-, mid- and long-term mortality rates proportionally to its severity. The findings of this study support the implementation of surgical strategies to prevent PPM in order to decrease mortality rates