Pd-II-mediated integration of isocyanides and azide ions might proceed via formal 1,3-dipolar cycloaddition between RNC ligands and uncomplexed azide

The generation of (tetrazolate)PdII complexes via the integration of (isocyanide)PdII precursors with uncomplexed azides and the verification of plausible reaction mechanisms.</p

Addition of N-nucleophiles to gold(III)-bound isocyanides leading to short-lived gold(III) acyclic diaminocarbene complexes

Addition of hydrazone to gold(iii)–isocyanides led to the generation of rare short-lived gold(iii) acyclic diaminocarbene complexes.</p

The phenanthroimidazole-based dizinc(II) complex as a fluorescent probe for the pyrophosphate ion as generated in polymerase chain reactions and pyrosequencing

A highly selective and sensitive phenanthroimidazole tagged Mannich base type dizinc(II) fluorescent probe (R-Zn2+) has been developed for the pyrophosphate ion (PPi) with a very low limit of detection (LOD) of 0.25 ppm; this also assesses PPi from DNA polymerization chain reaction (PCR)

Platinum Complexes with Chelating Acyclic Aminocarbene Ligands Work as Catalysts for Hydrosilylation of Alkynes

This work describes the preparation of a series of platinum–aminocarbene complexes [PtCl­{<u>C</u>­(NC^<i>a</i>(C₆R²R³R⁴R⁵CO<u>N</u>^<i>b</i>))N­(H)­R¹}­(CNR¹)]^<i>a–b</i> (<b>8</b>–<b>19</b>, 65–75% isolated yield) via the reaction of <i>cis</i>-[PtCl₂(CNR¹)₂] (R¹ = Cy <b>1</b>, <i>t</i>-Bu <b>2</b>, Xyl <b>3</b>, 2-Cl-6-MeC₆H₃ <b>4</b>) with 3-iminoisoindolin-1-ones HNC^<i>a</i>(C₆R²R³R⁴R⁵CON^<i>b</i>H) (R²–R⁵ = H <b>5</b>; R³ = Me, R², R⁴, R⁵ = H <b>6</b>; R³, R⁴ = Cl, R², R⁵ = H <b>7</b>). New complexes <b>17</b>–<b>19</b> were characterized by elemental analyses (C, H, N), ESI⁺-MS, Fourier transform infrared spectroscopy (FT-IR), one-dimensional (¹H, ¹³C­{¹H}), and two-dimensional (¹H,¹H correlation spectroscopy (COSY), ¹H,¹³C heteronuclear multiple quantum correlation (HMQC)/¹H,¹³C heteronuclear single quantum coherence (HSQC), ¹H,¹³C heteronuclear multiple bond correlation (HMBC)) NMR spectroscopy, and authenticity of known species <b>8</b>–<b>16</b> was confirmed by FT-IR and ¹H and ¹³C­{¹H} NMR. Complexes <b>8</b>–<b>19</b> were assessed as catalysts for hydrosilylation of terminal alkynes with hydrosilanes to give vinyl silanes, and complex [PtCl­{<u>C</u>­(NC^<i>a</i>(C₆H₃(5-Me)­CO<u>N</u>^<i>b</i>))N­(H)­(2-Cl-6-MeC₆H₃)}­{CN­(2-Cl-6-MeC₆H₃)}]^{<i>a</i>−<i>b</i>} (<b>18</b>) showed the highest catalytic activity. The catalytic system proposed operates at 80–100 °C for 4–6 h in toluene and with catalyst loading of 0.1 mol %, enabling the reaction of a number of terminal alkynes (PhCCH, <i>t</i>-BuCCH, and 4-(<i>t</i>-Bu)­C₆H₄CCH) with hydrosilanes (Et₃SiH, Pr₃SiH, <i>i</i>-Pr₃SiH, and PhMe₂SiH). Target vinyl silanes were prepared in 48–95% yields (as a mixture of α/β isomers) and with maximum turnover number of 8.4 × 10³. Hydrosilylation of internal alkynes (PhCCPh, Me­(CH₂)₂CC­(CH₂)₂Me, and PhCCMe) with hydrosilanes (Et₃SiH, PhMe₂SiH) led to the corresponding trisubstituted silylated alkenes in 86–94% yields. Initial observations on the mechanism of the catalytic action of platinum–ADC catalysts <b>8</b>–<b>19</b> suggested a molecular catalytic cycle

Phenyl carbohydrazone conjugated 2-oxoindoline as a new scaffold that augments the DNA and BSA binding affinity and anti-proliferative activity of a 1,10-phenanthroline based copper(II) complex

A new type of copper(II) complex, CuL(phen)(2)](NO3) (CuIP), where L ((E)-N'-(2-oxoindolin-3-ylidene) benzohydrazide) is a N donor ligand and phen is the N, N-donor heterocyclic 1,10-phenanthroline, has been synthesized. The phenyl carbohydrazone conjugated isatin-based ligand L and CuIP were characterized by elemental analysis, infrared, UV-Vis, H-1 and C-13 NMR and ESI-mass spectral data, as well as single-crystal X-ray diffraction. The interaction of calf thymus DNA (CT DNA) with L and CuIP has been investigated by absorption, fluorescence and viscosity titration methods. The complex CuIP displays better binding affinity than the ligand L. The observed DNA binding constant (K-b = 4.15(+/- 0.18) x 10(5) M-1) and binding site size (s = 0.19), viscosity data together with molecular docking studies of CuIP suggest groove binding and/or a partial intercalative mode of binding to CT DNA. In addition, CuIP shows good binding propensity to the bovine serum albumin (BSA) protein, giving a K-BSA value of 1.25(+/- 0.24) x 10(6) M-1. In addition, the docking studies on DNA and human serum albumin (HSA) CuIP interactions are consistent with the consequence of binding experiments. The in vitro anti-proliferative study establishes the anticancer potency of the CuIP against the human cervical (HeLa) and breast (MCF7) cancer cells; noncancer breast epithelial (MCF10a) cells have also been investigated. CuIP shows better cytotoxicity and sensitivity towards cancer cells over noncancer ones than L under identical conditions, with the appearance of apoptotic bodies. (C) 2014 Elsevier B.V. All rights reserved