Functional Tricuspid Regurgitation: Behind the Scenes of a Long-Time Neglected Disease

Severe tricuspid valve regurgitation has been for a long time a neglected valve disease, which has only recently attracted an increasing interest due to the notable negative impact on the prognosis of patients with cardiovascular disease. It is estimated that around 90% of tricuspid regurgitation is diagnosed as "functional" and mostly secondary to a primary left-sided heart disease and, therefore, has been usually interpreted as a benign condition that did not require a surgical management. Nevertheless, the persistence of severe tricuspid regurgitation after left-sided surgical correction of a valve disease, particularly mitral valve surgery, has been associated to adverse outcomes, worsening of the quality of life, and a significant increase in mortality rate. Similar results have been found when the impact of isolated severe tricuspid regurgitation has been studied. Current knowledge is shifting the "functional" categorization toward a more complex and detailed pathophysiological classification, identifying various phenotypes with completely different etiology, natural history and, potentially, an invasive management. The aim of this review is to offer a comprehensive guide for clinicians and surgeons with a systematic description of "functional" tricuspid regurgitation subtypes, an analysis centered on the effectiveness of existing surgical techniques and a focus on the emergent percutaneous procedures. This latter may be an attractive alternative to a standard surgical approach in patients with high-operative risk or isolated tricuspid regurgitation.Copyright © 2022 Vinciguerra, Sitges, Luis Pomar, Romiti, Domenech-Ximenos, D'Abramo, Wretschko, Miraldi and Greco

Engineering the microstructure and magnetism of La2_2CoMnO6_6 thin films by tailoring oxygen stoichiometry

We report on the magnetic and structural properties of ferromagnetic-insulating La$_2$CoMnO$_6$ thin films grown on top of (001) STO substrates by means of RF sputtering technique. Careful structural analysis, by using synchrotron X-ray diffraction, allows identifying two different crystallographic orientations that are closely related to oxygen stoichiometry and to the features (coercive fields and remanence) of the hysteresis loops. Both Curie temperature and magnetic hysteresis turn out to be dependent on the oxygen stoichiometry. In situ annealing conditions allow tailoring the oxygen content of the films, therefore controlling their microstructure and magnetic properties

La fusión glaciar en el Pirineo: condicionantes ambientales y primeros resultados bianuales en el glaciar de Infiernos (Pirineo aragonés)

Data are presented about the environmental characters of the Infiernos glacier and of the regression suffered in the last century, as well as the meltwater flow values corresponding to two daily cycle of the Infierno glacier. These values were measured at the end of the summer of 1998 and 1999. There is a close relationship between these data and both thermic rythms. This fact suggests that meltwater flow should become a useful additional parameter to explain the environmental control of the drainage systems derived from the glacier fusion, as well as the serious glacier regression happened in the last decades, indicative of balances between the accumulation nival and the ablation clearly negative. The data are accompanied of measures of regression glacier among the summers of 1998 and 1999.Se presentan datos acerca de las características ambientales del Glaciar del Infierno y de la regresión sufrida en el Último siglo, así como los valores de los caudales de fusión de dos ciclos diarios en este glaciar, medidos a finales de dos veranos consecutivos (años 1998 y 1999). La relación entre este dato y los ritmos térmicos es muy estrecha, lo cual permite disponer de un dato más, de gran importancia, para explicar el control ambiental en los sistemas de drenaje de la fusión glaciar, así como la acusada regresión glaciar de las últimas décadas, indicativa de balances entre la acumulación nival y la ablación claramente negativos. Los datos se acompañan de medidas de retroceso glaciar entre los veranos de 1998 y 1999

Agromorphological characterization and dollar spot fungus susceptibility in accessions of common bent (Agrostis capillaris L.) collected in northern Spain

Abstract Fourteen Agrostis capillaris accessions collected in northern Spain were characterized in a trial with a lowfertilization regime, carried out in two successive years (2004 and 2005). The commercial cultivar 'Golfin' was included in the study as a control. All accessions and the commercial cultivar were evaluated for 11 agromorphological characteristics and susceptibility to dollar spot disease, caused by Sclerotinia homoeocarpa F.T. Bennet. The data obtained were reduced to five principal components that cumulatively explained 85.4% of the total variance. Cluster analysis was useful in identifying four groups of accessions that described 50% of the phenotypic variation among accessions. Cluster 1 consisted of four accessions with the highest resistance to dollar spot, dark green colour, late heading date and high autumn turf quality. Cluster 2 included the two earliest heading accessions, dark green colour, intermediate tolerance to dollar spot and low autumn turf quality. Cluster 3 comprised six accessions with the latest heading date, dark green colour and low tolerance to dollar spot. Cluster 4 consisted of two accessions and the 'Golfin' cultivar, with lightest green colour, low autumn turf quality and the poorest tolerance to dollar spot. The results of this study suggest the potential value of some of these common bent accessions collected in northern Spain for turf and forage improvement. Additional key words: Agrostis tenuis, artificial inoculation, browntop, colonial bentgrass, multivariate analysis, turfgrass. Resumen Caracterización agromorfológica y susceptibilidad al hongo «dollar spot» en accesiones de agrostis común (Agrostis capillaris L.) recogidas en el Norte de España Catorce accesiones de Agrostis capillaris procedentes del norte de España se caracterizaron en un régimen de baja fertilización durante dos años (2004 y 2005) en un diseño de bloques completos al azar con dos repeticiones de 15 plantas por accesión (en total 30 plantas por accesión). El cultivar comercial 'Golfin' se incluyó como control en el estudio. Todas las accesiones y el cultivar 'Golfin' se evaluaron mediante 11 caracteres agromorfológicos y la susceptibilidad a la enfermedad fúngica «dollar spot» (Sclerotinia homoeocarpa F.T. Bennet). Los datos obtenidos se redujeron a cinco componentes principales que explicaron el 85,4% de la varianza total. Mediante una clasificación jerárquica se identificaron cuatro grupos, que describen el 50% de la variación fenotípica entre las accesiones. El grupo 1 incluyó cuatro accesiones con la mayor resistencia al «dollar spot», color verde oscuro, espigado tardío y muy buena calidad de césped en el otoño. El grupo 2 incluyó las dos accesiones más precoces de espigado, tolerancia intermedia al «dollar spot» y mala calidad de césped en el otoño. El grupo 3 comprendió seis accesiones tardías de espigado, color verde oscuro y baja tolerancia al «dollar spot». El grupo 4 incluyó dos accesiones y el cultivar 'Golfin' con color verde más claro, baja calidad otoñal de césped y la menor tolerancia al dollar spot. Los resultados de este estudio muestran el potencial de algunas de las accesiones de agrostis común procedentes del norte de España para uso en mejora de céspedes y forrajes. Palabras clave adicionales: Agrostis tenuis, análisis multivariable, césped, inoculación artificial

Quantum interference and Klein tunneling in graphene heterojunctions

The observation of quantum conductance oscillations in mesoscopic systems has traditionally required the confinement of the carriers to a phase space of reduced dimensionality. While electron optics such as lensing and focusing have been demonstrated experimentally, building a collimated electron interferometer in two unconfined dimensions has remained a challenge due to the difficulty of creating electrostatic barriers that are sharp on the order of the electron wavelength. Here, we report the observation of conductance oscillations in extremely narrow graphene heterostructures where a resonant cavity is formed between two electrostatically created bipolar junctions. Analysis of the oscillations confirms that p-n junctions have a collimating effect on ballistically transmitted carriers. The phase shift observed in the conductance fringes at low magnetic fields is a signature of the perfect transmission of carriers normally incident on the junctions and thus constitutes a direct experimental observation of ``Klein Tunneling.''Comment: 13 pages and 6 figures including supplementary information. The paper has been modified in light of new theoretical results available at arXiv:0808.048

Evolución reciente del glaciar del Infierno (Panticosa, Huesca)

Este artículo analiza la evolución del glaciar del pico Infierno desde un glaciar blanco hacia un glaciar cubierto y, tal vez, hacia un glaciar rocoso

Anatomy and origin of authochthonous late Pleistocene forced regression deposits, east Coromandel inner shelf, New Zealand: implications for the development and definition of the regressive systems tract

High-resolution seismic reflection data from the east Coromandel coast, New Zealand, provide details of the sequence stratigraphy beneath an autochthonous, wave dominated inner shelf margin during the late Quaternary (0-140 ka). Since c. 1 Ma, the shelf has experienced limited subsidence and fluvial sediment input, producing a depositional regime characterised by extensive reworking of coastal and shelf sediments during glacio-eustatic sea-level fluctuations. It appears that only one complete fifth-order (c. 100 000 yr) depositional sequence is preserved beneath the inner shelf, the late Pleistocene Waihi Sequence, suggesting any earlier Quaternary sequences were mainly cannibalised into successively younger sequences. The predominantly Holocene-age Whangamata Sequence is also evident in seismic data and modern coastal deposits, and represents an incomplete depositional sequence in its early stages of formation. A prominent aspect of the sequence stratigraphy off parts of the east Coromandel coast is the presence of forced regressive deposits (FRDs) within the regressive systems tract (RST) of the late Pleistocene Waihi Sequence. The FRDs are interpreted to represent regressive barrier-shoreface sands that were sourced from erosion and onshore reworking of underlying Pleistocene sediments during the period of slow falling sea level from isotope stages 5 to 2 (c. 112-18 ka). The RST is volumetrically the most significant depositional component of the Waihi Sequence; the regressive deposits form a 15-20 m thick, sharp-based, tabular seismic unit that downsteps and progrades continuously across the inner shelf. The sequence boundary for the Waihi Sequence is placed at the most prominent, regionally correlative, and chronostratigraphically significant surface, namely an erosional unconformity characterised in many areas by large incised valleys that was generated above the RST. This unconformity is interpreted as a surface of maximum subaerial erosion generated during the last glacial lowstand (c. 18 ka). Although the base of the RST is associated with a prominent regressive surface of erosion, this is not used as the sequence boundary as it is highly diachronous and difficult to identify and correlate where FRDs are not developed. The previous highstand deposits are limited to subaerial barrier deposits preserved behind several modern Holocene barriers along the coast, while the transgressive systems tract is preserved locally as incised-valley fill deposits beneath the regressive surface of erosion at the base of the RST. Many documented late Pleistocene RSTs have been actively sourced from fluvial systems feeding the shelf and building basinward-thickening, often stacked wedges of FRDs, for which the name allochthonous FRDs is suggested. The Waihi Sequence RST is unusual in that it appears to have been sourced predominantly from reworking of underlying shelf sediments, and thus represents an autochthonous FRD. Autochthonous FRDs are also present on the Forster-Tuncurry shelf in southeast Australia, and may be a common feature in other shelf settings with low subsidence and low sediment supply rates, provided shelf gradients are not too steep, and an underlying source of unconsolidated shelf sediments is available to source FRDs. The preservation potential of such autochthonous FRDs in ancient deposits is probably low given that they are likely to be cannibalised during subsequent sea-level falls

Theory of Scanning Tunneling Spectroscopy of Magnetic-Field-Induced Discrete Nodal States in a D-Wave Superconductor

In the presence of an external magnetic field, the low lying elementary excitations of a d-wave superconductor have quantized energy and their momenta are locked near the node direction. It is argued that these discrete states can most likely be detected by a local probe, such as a scanning tunneling microscope. The low temperature local tunneling conductance on the Wigner-Seitz cell boundaries of the vortex lattice is predicted to show peaks spaced as $\pm \sqrt{n}, n ={0,1,2, ...}$. The $n=0$ peak is anomalous, and it is present only if the superconducting order parameter changes sign at certain points on the Fermi surface. Away from the cell boundary, where the superfluid velocity is nonzero, each peak splits, in general, into four peaks, corresponding to the number of nodes in the order parameter.Comment: RevTeX 3.0, 4 pages, 3 figures (included

Environmental drivers of distribution and reef development of the Mediterranean coral Cladocora caespitosa

Cladocora caespitosa is the only Mediterranean scleractinian similar to tropical reef-building corals. While this species is part of the recent fossil history of the Mediterranean Sea, it is currently considered endangered due to its decline during the last decades. Environmental factors affecting the distribution and persistence of extensive bank reefs of this endemic species across its whole geographic range are poorly understood. In this study, we examined the environmental response of C. caespitosa and its main types of assemblages using ecological niche modeling and ordination analysis. We also predicted other suitable areas for the occurrence of the species and assessed the conservation effectiveness of Mediterranean marine protected areas (MPAs) for this coral. We found that phosphate concentration and wave height were factors affecting both the occurrence of this versatile species and the distribution of its extensive bioconstructions in the Mediterranean Sea. A set of factors (diffuse attenuation coefficient, calcite and nitrate concentrations, mean wave height, sea surface temperature, and shape of the coast) likely act as environmental barriers preventing the species from expansion to the Atlantic Ocean and the Black Sea. Uncertainties in our large-scale statistical results and departures from previous physiological and ecological studies are also discussed under an integrative perspective. This study reveals that Mediterranean MPAs encompass eight of the ten banks and 16 of the 21 beds of C. caespitosa. Preservation of water clarity by avoiding phosphate discharges may improve the protection of this emblematic species.Spanish Ministry of Economy and Competitiveness [CTM2014-57949-R]info:eu-repo/semantics/publishedVersio

Dual-functioning transcription factors in the developmental gene network of Drosophila melanogaster

Quantitative models for transcriptional regulation have shown great promise for advancing our understanding of the biological mechanisms underlying gene regulation. However, all of the models to date assume a transcription factor (TF) to have either activating or repressing function towards all the genes it is regulating.In this paper we demonstrate, on the example of the developmental gene network in D. melanogaster, that the data-fit can be improved by up to 40% if the model is allowing certain TFs to have dual function, that is, acting as activator for some genes and as repressor for others. We demonstrate that the improvement is not due to additional flexibility in the model but rather derived from the data itself. We also found no evidence for the involvement of other known site-specific TFs in regulating this network. Finally, we propose SUMOylation as a candidate biological mechanism allowing TFs to switch their role when a small ubiquitin-like modifier (SUMO) is covalently attached to the TF. We strengthen this hypothesis by demonstrating that the TFs predicted to have dual function also contain the known SUMO consensus motif, while TFs predicted to have only one role lack this motif.We argue that a SUMOylation-dependent mechanism allowing TFs to have dual function represents a promising area for further research and might be another step towards uncovering the biological mechanisms underlying transcriptional regulation