Energy cost of resistive exercise

The energy cost of performing 1 and 3 sets of strength-type (6-8 RM) and endurance-type (30-35 RM) bench press exercise was estimated by indirect calorimetry in 10 male college students. The total net energy cost of performing 3 sets of endurance-type resistive exercise (20.57 ± 1.86 kcal) was significantly (p-1) the strength-type exercise (2.35 ± 0.19) resulted in a significantly (

Genetic elimination of field-cage populations of Mediterranean fruit flies

The Mediterranean fruit fly (medfly, Ceratitis capitata Wiedemann) is a pest of over 300 fruits, vegetables and nuts. The sterile insect technique (SIT) is a control measure used to reduce the reproductive potential of populations through the mass release of sterilized male insects that mate with wild females. However, SIT flies can display poor field performance, due to the effects of mass-rearing and of the irradiation process used for sterilization. The development of female-lethal RIDL (release of insects carrying a dominant lethal) strains for medfly can overcome many of the problems of SIT associated with irradiation. Here, we present life-history characterizations for two medfly RIDL strains, OX3864A and OX3647Q. Our results show (i) full functionality of RIDL, (ii) equivalency of RIDL and wild-type strains for life-history characteristics, and (iii) a high level of sexual competitiveness against both wild-type and wild-derived males. We also present the first proof-of-principle experiment on the use of RIDL to eliminate medfly populations. Weekly releases of OX3864A males into stable populations of wild-type medfly caused a successive decline in numbers, leading to eradication. The results show that genetic control can provide an effective alternative to SIT for the control of pest insects

Visualizing stability in studies: the moving average meta-analysis (MA2)

Relative clinical benefits are often visually explored and formally analysed through a (cumulative) meta-analysis. In this manuscript, we introduce and further explore the moving average meta-analysis to aid towards the exploration and visualization of stability in a meta-analysis.Comment: 10 pages, 2 figures, 1 tabl

Spectrophotometric investigations of Blue Compact Dwarf Galaxies: Markarian 35

We present results from a detailed spectrophotometric analysis of the blue compact dwarf galaxy Mrk 35 (Haro 3), based on deep optical (B,V,R,I) and near-IR (J,H,K) imaging, Halpha narrow-band observations and long-slit spectroscopy. The optical emission of the galaxy is dominated by a central young starburst, with a bar-like shape, while an underlying component of stars, with elliptical isophotes and red colors, extends more than 4 kpc from the galaxy center. High resolution Halpha and color maps allow us to identify the star-forming regions, to spatially discriminate them from the older stars, and to recognize several dust patches. We derive colors and Halpha parameters for all the identified star-forming knots. Observables derived for each knot are corrected for the contribution of the underlying older stellar population, the contribution by emission lines, and from interstellar extinction, and compared with evolutionary synthesis models. We find that the contributions of these three factors are by no means negligible and that they significantly vary across the galaxy. Therefore, careful quantification and subtraction of emission lines, galaxy host contribution, and interstellar reddening at every galaxy position, are essential to derive the properties of the young stars in BCDs. We find that we can reproduce the colors of all the knots with an instantaneous burst of star formation and the Salpeter initial mass function with an upper mass limit of 100 M_solar. In all cases the knots are just a few Myr old. The underlying population of stars has colors consistent with being several Gyr old.Comment: 21 pages, 13 figures. Accepted for publication in ApJ, tentatively scheduled for the ApJ November 1, 2007 v669n1 issu

Contrasting Pattern of Chronic Inflammatory Bowel Disease in Primary and Autoimmune Sclerosing Cholangitis.

To access publisher's full text version of this article click on the hyperlink at the bottom of the pagePrimary sclerosing cholangitis (PSC) and autoimmune sclerosing cholangitis (AISC) are related, but distinct chronic liver diseases. PSC is associated with a high prevalence of ulcerative colitis while the intestinal inflammation associated with AISC is less well characterised.To assess and contrast aspects of intestinal inflammation in patients with AISC and PSC and compare the clinical features with those of patients with ulcerative colitis and Crohn's disease.23 and 22 patients with AISC and PSC, respectively, underwent review of colonoscopy and biopsy findings, capsule enteroscopy and assessment of clinical and inflammatory (faecal calprotectin) disease activity, which was compared with that of patients with ulcerative colitis and Crohn's disease (n = 55 each).Five and 6 patients with AISC and PSC, respectively, had normal colonoscopy and faecal calprotectin levels of 34.4 ± 8.3 and 39.7 ± 8.4 μg/g, respectively (normal 0.05) between patients with intestinal inflammation in AISC (588 ± 549 μg/g), PSC (421 ± 351 μg/g), ulcerative colitis (501 ± 656 μg/g) or Crohn's disease (476 ± 571 μg/g). Capsule enteroscopy showed that 7 of 18 (39%) (p < 0.03) of those with AISC had small bowel mucosal breaks whereas no patient with PSC had these findings.Collectively these findings lend support to the suggestion that the chronic inflammatory bowel disease associated with PSC and in particular AISC may represent a distinct nosologic entity different from classic ulcerative colitis and Crohn's disease

An imaging and spectroscopic study of the very metal-deficient blue compact dwarf galaxy Tol 1214--277

We present a spectrophotometric study based on VLT/FORS I observations of one of the most metal-deficient blue compact dwarf (BCD) galaxies known, Tol 1214-277 (Z ~ Zsun/25). The data show that roughly half of the total luminosity of the BCD originates from a bright and compact starburst region located at the northeastern tip of a faint dwarf galaxy with cometary appearance. The starburst has ignited less than 4 Myr ago and its emission is powered by several thousands O7V stars and ~ 170 late-type nitrogen Wolf-Rayet stars located within a compact region with < 500 pc in diameter. For the first time in a BCD, a relatively strong [Fe V] 4227 emission line is seen which together with intense He II 4686 emission indicates the presence of a very hard radiation field in Tol 1214-277. We argue that this extraordinarily hard radiation originates from both Wolf--Rayet stars and radiative shocks in the starburst region. The structural properties of the low-surface-brightness (LSB) component underlying the starburst have been investigated by means of surface photometry down to 28 B mag/sq.arcsec. We find that, for a surface brightness level fainter than ~ 24.5 B mag/sq.arcsec, an exponential fitting law provides an adequate approximation to its radial intensity distribution. The broad-band colors in the outskirts of the LSB component of Tol 1214-277 are nearly constant and are consistent with an age below one Gyr. This conclusion is supported by the comparison of the observed spectral energy distribution (SED) of the LSB host with theoretical SEDs.Comment: 17 pages, 11 Postscript figures, uses emulateapj.sty, to appear in Astronomical Journa

Cardiac Resynchronization Therapy and Proarrhythmia: Weathering the Storm

In patients with significant left ventricular (LV) dysfunction and congestive heart failure despite optimal medical therapy, implantation of cardiac resynchronization therapy-defibrillator (CRT-D) devices has been shown to improve symptoms and diminish ventricular tachyarrhythmia susceptibility.We describe the case of a patient with dilated cardiomyopathy who developed ventricular tachycardia storm (VTS) one month after the implantation of a CRT-D device. VTS was initially controlled with pharmacotherapy, allowing the patient to continue with biventricular pacing. Two months later the patient was readmitted due to multiple episodes of polymorphic ventricular tachycardia. VTS was refractory to various intravenous antiarrhythmic drugs and it was finally controlled only when LV pacing was turned off.In patients with heart failure treated with CRT-D, VTS can occur and is best managed by turning off LV pacing. Our report raises an important and concerning issue of biventricular pacing causing ‘proarrhythmia’ in rare instances

Extreme glacial cooling likely led to hominin depopulation of Europe in the Early Pleistocene

The oldest known hominin remains in Europe [~1.5 to ~1.1 million years ago (Ma)] have been recovered from Iberia, where paleoenvironmental reconstructions have indicated warm and wet interglacials and mild glacials, supporting the view that once established, hominin populations persisted continuously. We report analyses of marine and terrestrial proxies from a deep-sea core on the Portugese margin that show the presence of pronounced millennial-scale climate variability during a glacial period ~1.154 to ~1.123 Ma, culminating in a terminal stadial cooling comparable to the most extreme events of the last 400,000 years. Climate envelope–model simulations reveal a drastic decrease in early hominin habitat suitability around the Mediterranean during the terminal stadial. We suggest that these extreme conditions led to the depopulation of Europe, perhaps lasting for several successive glacial-interglacial cycles

CROCODILE \\ Incorporating medium-resolution spectroscopy of close-in directly imaged exoplanets into atmospheric retrievals via cross-correlation

The investigation of the atmospheres of closely separated, directly imaged gas giant exoplanets is challenging due to the presence of stellar speckles that pollute their spectrum. To remedy this, the analysis of medium- to high-resolution spectroscopic data via cross-correlation with spectral templates (cross-correlation spectroscopy) is emerging as a leading technique. We aim to define a robust Bayesian framework combining, for the first time, three widespread direct-imaging techniques, namely photometry, low-resolution spectroscopy, and medium-resolution cross-correlation spectroscopy in order to derive the atmospheric properties of close-in directly imaged exoplanets. Our framework CROCODILE (cross-correlation retrievals of directly imaged self-luminous exoplanets) naturally combines the three techniques by adopting adequate likelihood functions. To validate our routine, we simulated observations of gas giants similar to the well-studied $\beta$~Pictoris~b planet and we explored the parameter space of their atmospheres to search for potential biases. We obtain more accurate measurements of atmospheric properties when combining photometry, low- and medium-resolution spectroscopy into atmospheric retrievals than when using the techniques separately as is usually done in the literature. We find that medium-resolution ($R \approx 4000$) K-band cross-correlation spectroscopy alone is not suitable to constrain the atmospheric properties of our synthetic datasets; however, this problem disappears when simultaneously fitting photometry and low-resolution ($R \approx 60$) spectroscopy between the Y and M bands. Our framework allows the atmospheric characterisation of directly imaged exoplanets using the high-quality spectral data that will be provided by the new generation of instruments such as VLT/ERIS, JWST/MIRI, and ELT/METIS