268 research outputs found
Cardiovascular effects of an arginase II selective inhibitor
For the first time in vitro experiments there were studied the inhibitory activity and safety of potential molecules arginase II selective inhibitors from the group of norleucine derivatives. Also first the substance under the code ZB49-0010C from the group of norleucine derivatives showed the greatest selectivity and inhibitory activity against arginase II in experiments in vitro. However, this substance in vivo exerts dose-dependent hypotensive action and cardioprotective and endothelial protective effects on the L-NAME induced and homocysteine-induced endothelial dysfunction (ED), which are most pronounced at a dose of 10 mg/kg in intragastric administratio
Human recombinant erythropoietin gradient dosage influence on ischemic and reperfusion liver injury
We investigate influence of human recombinant erythropoietin different dosage on blood flow velocity and morphological changes in liver during ischemic and reperfusion injury. It was proved what optimal preconditioning dosage is 50 IU/k
Disorder-driven superconductor-normal metal phase transition in quasi-one-dimensional organic conductors
Effects of non-magnetic disorder on the critical temperature T_c and on
diamagnetism of quasi-one-dimensional superconductors are reported. The energy
of Josephson-coupling between wires is considered to be random, which is
typical for dirty organic superconductors. We show that this randomness
destroys phase coherence between wires and that T_c vanishes discontinuously at
a critical disorder-strength. The parallel and transverse components of the
penetration-depth are evaluated. They diverge at different critical
temperatures T_c^{(1)} and T_c, which correspond to pair-breaking and
phase-coherence breaking respectively. The interplay between disorder and
quantum phase fluctuations is shown to result in quantum critical behavior at
T=0, which manifests itself as a superconducting-normal metal phase transition
of first-order at a critical disorder strength.Comment: 12 pages, 3 figure
Contributions of spontaneous phase slippage to linear and non-linear conduction near the Peierls transition in thin samples of o-TaS_3
In the Peierls state very thin samples of TaS_3 (cross-section area \sim
10^{-3} mkm^2) are found to demonstrate smearing of the I-V curves near the
threshold field. With approaching the Peierls transition temperature, T_P, the
smearing evolves into smooth growth of conductance from zero voltage
interpreted by us as the contribution of fluctuations to the non--linear
conductance. We identify independently the fluctuation contribution to the
linear conductance near T_P. Both linear and non-linear contributions depend on
temperature with close activation energies \sim (2 - 4) x 10^3 K and apparently
reveal the same process. We reject creep of the {\it continuous} charge-density
waves (CDWs) as the origin of this effect and show that it is spontaneous phase
slippage that results in creep of the CDW. A model is proposed accounting for
both the linear and non-linear parts of the fluctuation conduction up to T_P.Comment: 6 pages, 5 Postscript figure, RevTeX, accepted for publication in PR
Thermal non-equilibrium effects in quantum reflection
We show that the quantum reflection coefficient of ultracold heavy atoms
scattering off a dielectric surface can be tuned in a wide range by suitable
choice of surface and environment temperatures. This effect results from a
temperature dependent long-range repulsive part of the van der
Waals-Casimir-Polder-Lifshitz atom-surface interaction potential
Discretized rotation has infinitely many periodic orbits
For a fixed k in (-2,2), the discretized rotation on Z^2 is defined by
(x,y)->(y,-[x+ky]). We prove that this dynamics has infinitely many periodic
orbits.Comment: Revised after referee reports, and added a quantitative statemen
Use of L-arginine immobilised on activated carbon for pharmacological correction of endothelial disfunction
For the first time a complex of L-arginine sodium salt of sulfate of cellulose acetate on activated carbon. To investigate the processes of sorption-desorption of L-arginine in a model environmen
Influence mechanisms of mineralocorticoid receptor antagonist (spironolactone) among elderly patients with chronic heartfailure against ischemic disease
It was determined that a significant positive dynamics of TNF-synthesis suppression by 67.0% (p 0.0001) was established in the 4th group of patients taking combined therapy with the blocker of mineralocorticoid receptors with spironolacton
Parametric Generation of Second Sound by First Sound in Superfluid Helium
We report the first experimental observation of parametric generation of
second sound (SS) by first sound (FS) in superfluid helium in a narrow
temperature range in the vicinity of . The temperature dependence
of the threshold FS amplitude is found to be in a good quantitative agreement
with the theory suggested long time ago and corrected for a finite geometry.
Strong amplitude fluctuations and two types of the SS spectra are observed
above the bifurcation. The latter effect is quantitatively explained by the
discreteness of the wave vector space and the strong temperature dependence of
the SS dissipation length.Comment: 4 pages, 4 postscript figures, REVTE
Integrated evaluation of the endothelioprotective activity of an innovative peptide simulating the alpha-helix of B-erythropoethin in L-name-induced nitrogen oxide deficiency at the late gestation period
To study the efficiency of using carbamylated darbepoetin, asialized erythropoietin and an 11-amino acid peptide that simulating the spatial structure of the B-erythropoietin alpha-helix in the correction of L-NAME-induced nitric oxide deficiency in the late gestation perio
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