Automated water monitor system field demonstration test report. Volume 1: Executive summary

A system that performs water quality monitoring on-line and in real time much as it would be done in a spacecraft, was developed and demonstrated. The system has the capability to determine conformance to high effluent quality standards and to increase the potential for reclamation and reuse of water

Automated water monitor system field demonstration test report. Volume 2: Technical summary

The NASA Automatic Water Monitor System was installed in a water reclamation facility to evaluate the technical and cost feasibility of producing high quality reclaimed water. Data gathered during this field demonstration test are reported

The relation between cardiac 123I-mIBG scintigraphy and functional response 1 year after CRT implantation

Cardiac resynchronization therapy (CRT) is a disease-modifying therapy in patients with chronic heart failure (CHF). Current guidelines ascribe CRT eligibility on three parameters only: left ventricular ejection fraction (LVEF), QRS duration, and New York Heart Association (NYHA) functional class. However, one-third of CHF patients does not benefit from CRT. This study evaluated whether 123I-meta-iodobenzylguanidine (123I-mIBG) assessed cardiac sympathetic activity could optimize CRT patient selection

Joint optimization of customer segmentation and marketing policy to maximize long-term profitability

With the advent of one-to-one marketing media, e.g. targeted direct mail or internet marketing, the opportunities to develop targeted marketing campaigns are enhanced in such a way that it is now both organizationally and economically feasible to profitably support a substantially larger number of marketing segments. However, the problem of what segments to distinguish, and what actions to take towards the different segments increases substantially in such an environment. A systematic analytic procedure optimizing both steps would be very welcome.In this study, we present a joint optimization approach addressing two issues: (1) the segmentation of customers into homogeneous groups of customers, (2) determining the optimal policy (i.e., what action to take from a set of available actions) towards each segment. We implement this joint optimization framework in a direct-mail setting for a charitable organization. Many previous studies in this area highlighted the importance of the following variables: R(ecency), F(requency), and M(onetary value). We use these variables to segment customers. In a second step, we determine which marketing policy is optimal using markov decision processes, following similar previous applications. The attractiveness of this stochastic dynamic programming procedure is based on the long-run maximization of expected average profit. Our contribution lies in the combination of both steps into one optimization framework to obtain an optimal allocation of marketing expenditures. Moreover, we control segment stability and policy performance by a bootstrap procedure. Our framework is illustrated by a real-life application. The results show that the proposed model outperforms a CHAID segmentation

Interleukin-5 Potentiates Sulfidopeptide Leukotriene Production by Human Eosinophils

Interleukin-5 (IL-5) has been shown to be a selective eosinophil growth and differentiation factor. In the present study, the effect of recombinant human IL-5 on human eosinophil sulfidopeptide leukotriene production was investigated. IL-5 did not affect leukotriene synthesis in unstimulated eosinophils. However, IL-5 potentiated leukotriene synthesis by eosinophils stimulated with serum treated zymosan (STZ) or the calcium ionophore A23187 by 69% and 135%, respectively. The priming effect of IL-5 was dose dependent, with significant stimulation occurring at 1 000 U/ml for STZ and 100-1 000 U/ml for A23187. Pre-incubation with IL-5 did not increase leukotriene synthesis further

PSMA, EpCAM, VEGF and GRPR as Imaging Targets in Locally Recurrent Prostate Cancer after Radiotherapy

In this retrospective pilot study, the expression of the prostate-specific membrane antigen (PSMA), the epithelial cell adhesion molecule (EpCAM), the vascular endothelial growth factor (VEGF) and the gastrin-releasing peptide receptor (GRPR) in locally recurrent prostate cancer after brachytherapy or external beam radiotherapy (EBRT) was investigated, and their adequacy for targeted imaging was analyzed. Prostate cancer specimens were collected of 17 patients who underwent salvage prostatectomy because of locally recurrent prostate cancer after brachytherapy or EBRT. Immunohistochemistry was performed. A pathologist scored the immunoreactivity in prostate cancer and stroma. Staining for PSMA was seen in 100% (17/17), EpCAM in 82.3% (14/17), VEGF in 82.3% (14/17) and GRPR in 100% (17/17) of prostate cancer specimens. Staining for PSMA, EpCAM and VEGF was seen in 0% (0/17) and for GRPR in 100% (17/17) of the specimens’ stromal compartments. In 11.8% (2/17) of cases, the GRPR staining intensity of prostate cancer was higher than stroma, while in 88.2% (15/17), the staining was equal. Based on the absence of stromal staining, PSMA, EpCAM and VEGF show high tumor distinctiveness. Therefore, PSMA, EpCAM and VEGF can be used as targets for the bioimaging of recurrent prostate cancer after EBRT to exclude metastatic disease and/or to plan local salvage therapy

Coherence properties of exciton-polariton OPO condensates in one and two dimensions

We give an overview of the coherence properties of exciton-polariton condensates generated by optical parametric scattering. Different aspects of the first-order coherence (g (1)) have been investigated. The spatial coherence extension of a two-dimensional (2D) polariton system, below and at the parametric threshold, demonstrates the development of a constant phase coherence over the entire condensate, once the condensate phase transition takes place. The effect on coherence of the photonic versus excitonic nature of the condensates is also examined. The coherence of a quasi-1D trap, composed of a line defect, is studied, showing the detrimental effect of reduced dimensionality on the establishment of the long range order. In addition, the temporal coherence decay, g (1)(τ), reveals a fast decay in contrast with the 2D case. The situation of a quasi-1D condensate coexisting with a 2D one is also presentedThe work was supported by the FP7 ITNs Clermont4 (235114) and Spin-optronics (237252), the Spanish MEC (MAT2011-22997), CAM (S-2009/ESP-1503) and Science Foundation Ireland SIRG/I1592 (PRE