Redistributing More Than the LGBTQ2S Acronym? Planning Beyond Recognition and Rainbows on Vancouver's Periphery

Just urban planning recognizes sociocultural differences and addresses inequality by implementing redistributive mechanisms that move beyond urban neoliberal practices of aestheticization and festivalization. Such planning practices are only beginning to address sexual and gender minority recognition in central urban areas while metronormative assumptions about their geographies absolve suburban municipalities of accountability for LGBTQ+ inclusions. In suburban municipalities, therefore, an LGBTQ+ politics of recognition rarely synchronizes with a politics of redistribution to foster sustained and transformative responses across the professional and managerial boundaries between planning and other local government functions. Consequently, a reparative civic "rainbowization" stands in for transformative urban planning, producing only partial and commodifiable inclusions in the landscape that become absolution for inaction on more evidence-based goals and measurable targets. Drawing on a database of public-facing communication records referencing LGBTQ2S themes for three adjacent peripheral municipalities in the Vancouver city-region (Burnaby, New Westminster, and Surrey), this article analyses the tension between contemporary planning’s civic actions of LGBTQ+ recognition and outcomes of redistribution. In suburban municipalities, a rainbow-washing politics of recognition sidelines transformative planning and policy resulting in little more than the distribution of the LGBTQ2S acronym across municipal documents

Queer(ing) Urban Planning and Municipal Governance

To queer urban planning and municipal governance requires explicit civic engagement with sexual and gender minority inclusions, representations and needs in urban plans and policies across departmental and committee silos. This collection questions the hetero-cis-normative assumptions of urban planning and examines the integration of LGBTQ+ issues in municipal governance at the interface of community activism, bureaucratic procedures, and political intervention. The editorial summarizes the contributions to this thematic issue within a tripartite thematic framework: 1) counter-hegemonic reactions to hetero-cis-normativities; 2) queering plans and policies; and 3) governance coalitions and LGBTQ+ activisms

Impact of Recent Evidence on Use of Hormone Therapy in the South African Private Sector (2001-2005)

Background: The release of the results of the oestrogen plus progesterone therapy (EPT) arm of the Women\'s Health Initiative (WHI) in July 2002 started a worldwide process of reconsideration of the rationale behind hormone therapy (HT). This process was accelerated after the release of the results from the oestrogen-only (ET) arm of the same study. The results of the WHI reinforced the indications of HT to alleviate vasomotor symptoms and to prevent bone loss associated with early menopause, but refuted the possibility of cardioprotective effects and raised uncertainty around the risk of breast cancer for long-term users. In response, new guidelines and position statements were developed to aid healthcare practitioners and patients in various countries, including South Africa. The dissemination and penetration of all this information has been assessed in a number of countries, but the extent of its effect on the South African market is as yet unknown. Accordingly, the aim of this study was to assess the use of HT in the South African private sector from 2001 to 2005. Methods: Monthly HT sales data for January 2001 to October 2005 were obtained from IMS Health (SA). Three successive periods were compared: (1) January 2001 to June 2002 (discontinuation of the WHI oestrogen plus progestogen arm), (2) July 2002 to February 2004 (termination of the WHI oestrogen only arm) and (3) March 2004 to October 2005. Results: Overall, sales of HT fell 6.9% between periods 1 and 2 and 14.6% between periods 2 and 3. The total sales of ET predominated; they were more than double those of EPT. For ET, the sale of conjugated equine oestrogen (CEE) preparations exceeded those of non-CEE ET preparations, while for EPT preparations the reverse was true. The decline in ET sales was mostly accounted for by the fall in sales of CEE, by 9.8% and 20.6% for the two periods respectively. There was an increase in sales of both low-dose CEE and non-CEE, although the magnitude of increase in the case of the latter was much greater. Throughout the entire study period, CEE 0.625 mg tablets were found to account for the greatest sales volumes. Private sector sales represented 74.4% of total national HT sales over this period. Conclusion: The release of the WHI findings resulted in a modest decrease in HT sales in South Africa, although it was less dramatic than sales reported elsewhere. The change in prescribing cannot be attributed to any single factor. Factors such as publicity, adherence to new guidelines, and pharmaceutical marketing may all have contributed. Guidelines need to be updated as the results of new research continue to be published. There is also a need to periodically review prescribing trends, and to assess compliance with evidence-based guidelines, in order to improve the quality of medicines use. The majority of prescriptions for HT in South Africa are written by general practitioners, rather than by specialists. It is thus imperative that guidelines be appropriately framed for this market, as well as interpreted and applied. Keywords: hormone therapy (HT), South Africa, Women's Health Initiative South African Family Practice Vol. 50 (6) 2008: pp. 42-42

New light on the ‘Drummer of Tedworth’: conflicting narratives of witchcraft in Restoration England

This paper presents a definitive text of hitherto little-known early documents concerning ‘The Drummer of Tedworth’, a poltergeist case that occurred in 1662-3 and became famous not least due to its promotion by Joseph Glanvill in his demonological work, Saducismus Triumphatus. On the basis of these and other sources, it is shown how responses to the events at Tedworth evolved from anxious piety on the part of their victim, John Mompesson, to confident apologetic by Glanvill, before they were further affected by the emergence of articulate scepticism about the case

Selective, non-covalent conjugation of synthetic peptides with recombinant proteins mediated by host-guest chemistry.

The combination of potent chemical moieties with biologically active proteins is key to some of today's most innovative therapeutic drugs. In order to obviate any chemical modification of the proteins, we present a novel and powerful strategy for the selective conjugation of recombinant protein domains with synthetically derived peptides via a cucurbit[8]uril host-guest chemistry approach.We thank Alexandra Rieck, Isabelle Sermadiras, Benjamin Kemp and Jennifer Spooner for help with the expression and purification of the Fc and Tn3 domains, Jefferson Revell and Jacky Metcalfe for help with the synthesis of modified peptides and Christel Veyssier for help with the light scattering experiments. RJG was supported by the MedImmune postdoctoral program. SS was supported by ERC Starting Investigator grant ASPiRe (No. 240629).This is the final version of the article. It first appeared from Royal Society of Chemistry via http://dx.doi.org/10.1039/C6CC00405

Malignancy rates in Crohn's disease patients with perianal fistula: A German retrospective cohort study

BACKGROUND Patients with inflammatory bowel disease are at increased risk of colorectal and extra-intestinal cancer. However, the overall cancer risk in patients with Crohn's disease (CD) with perianal fistulas (PF) (CPF) and those with CD without PF (non-PF CD) is unclear. OBJECTIVE To describe the prevalence and incidence of cancer in patients with CPF and non-PF CD, and to estimate incidence rate ratio (IRR) of cancer between CPF and non-PF CD groups. METHODS A retrospective cohort study was conducted using the German InGef (Institute for Applied Health Research Berlin) research database. Patients with a CD record and PF from 1 January 2013 to 31 December 2014 were identified and followed up from 1 January 2015 until the first occurrence of cancer, end of health insurance contributing data, death, or end of study period (31 December 2020). Prevalence of any type of cancer including patients with CD diagnosed with cancer in the selection period and incidence of cancer excluding patients with CD diagnosed with cancer in the selection period were calculated. RESULTS In total, 10,208 patients with CD were identified. Of 824 patients with CPF (8.1%), 67 had had a malignancy (6-year period crude malignancy prevalence 8.13% [95% confidence interval (CI) 6.36%-10.21%]), which was lower than patients with non-PF CD (19.8% [95% CI 19%-20.6%]). Incidence (per 100,000 person-years) in patients with CPF was 1184 (95% CI 879-1561) and in non-PF CD was 2365 (95% CI 2219-2519). There was no significant difference in the adjusted IRR of cancer for the CPF group compared with the non-PF CD group (0.83 [95% CI 0.62-1.10]; p = 0.219). CONCLUSION There was no significant difference in the incidence of any cancer in patients with CPF compared with non-PF CD. However, patients with CPF had a higher numerical risk of cancer than the general German population

Impact of comorbidities on the safety and effectiveness of hip and knee arthroplasty surgery: A national observational study

AIMS: Access to joint replacement is being restricted for patients with comorbidities in a number of high-income countries. However, there is little evidence on the impact of comorbidities on outcomes. The purpose of this study was to determine the safety and effectiveness of hip and knee arthroplasty in patients with and without comorbidities. METHODS: In total, 312,079 hip arthroplasty and 328,753 knee arthroplasty patients were included. A total of 11 common comorbidities were identified in administrative hospital records. Safety risks were measured by assessing length of hospital stay (LOS) and 30-day emergency readmissions and mortality. Effectiveness outcomes were changes in Oxford Hip or Knee Scores (OHS/OKS) (scale from 0 (worst) to 48 (best)) and in health-related quality of life (EQ-5D) (scale from 0 (death) to 1 (full health)) from immediately before, to six months after, surgery. Regression analysis was used to estimate adjusted mean differences (LOS, change in OHS/OKS/EQ-5D) and risk differences (readmissions and mortality). RESULTS: Patients with comorbidities had a longer LOS and higher readmission and mortality rates than patients without. In hip arthroplasty patients with heart disease, for example, LOS was 1.20 days (95% confidence interval (CI) 1.15 to 1.25) longer and readmission rate was 1.52% (95% CI 1.34% to 1.71%) and mortality 0.19% (95% CI 0.15% to 0.23%) higher. Similar patterns were observed for knee arthroplasty patients. Patients without comorbidities reported large improvements in function (mean improvement OHS 21.3 (SD 9.91) and OKS 15.9 (SD 10.0)). Patients with comorbidities reported only slightly smaller improvements. In patients with heart disease, mean improvement in OHS was 0.39 (95% CI 0.27 to 0.51) and in OKS 0.56 (95% CI 0.45 to 0.67) less than in patients without comorbidities. There were no significant differences in EQ-5D improvement. CONCLUSION: Comorbidities were associated with small increases in adverse safety risks but they have little impact on pain or function in patients undergoing hip or knee arthroplasty. These results do not support restricting access to hip and knee arthroplasty for patients with common comorbidities. Cite this article: Bone Joint J 2021;103-B(1):56-64

Multifractal Analysis of Soil Surface Roughness

Soil surface roughness (SSR) is a parameter highly suited to the study of soil susceptibility to wind and water erosion. The development of a methodology for quantifying SSR is therefore instrumental to soil evaluation. We developed such a method, based on the multifractal analysis (MFA) of soil elevation measurements collected at the intersections on a 2- by 2-cm2 grid in a 200- by 200-cm2 plot. Samples were defined using the gliding box algorithm (GB), in which a box of a given size "glides" across the grid map in all possible directions. The advantage of the GB over the box counting algorithm is that it yields a greater number of large sample sizes, which usually leads to better statistical results. Standard deviation, semivariogram fractal dimension, and semivariogram crossover length were estimated for all scenarios to compare the results of SSR multifractal analysis to indices found with traditional techniques. For its high sensitivity to the spatial arrangement implicit in a data set, MFA appears to be better suited than classical indices to compare plots tilled under different management criteria. The results showed that MFA is able to effectively reflect the heterogeneity and complexity of agricultural SSR. Based on this type of analysis, two new indices have been defined to compare the multifractal spectrum characteristics of the raw data to the characteristics of a random field with the same average and SD

Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis

Variation in body iron is associated with or causes diseases, including anaemia and iron overload. Here, we analyse genetic association data on biochemical markers of iron status from 11 European-population studies, with replication in eight additional cohorts (total up to 48,972 subjects). We find 11 genome-wide-significant (