From people to prototypes and products: ethnographic liquidity and the Intel Global Aging experience study

This article documents how a large-scale, multi-site, ethnographic research project into aging populations, the Global Aging Experience Study, led to the development of concepts, product prototypes, and products for the independent living market. Successfully leveraging the output of ethnographic research within large organizations and product groups is often fraught with challenges. Ethnographic research produced within an industry context can be difficult for an organization to thoroughly capitalize on. However, careful research design and sound knowledge transfer activities can produce highly successful outcomes that can be thoroughly absorbed into an organization, and the data can lend itself to re-analysis. Our research was conducted by the Product Research and Innovation Team in the Intel Digital Health Group, and the work was done in Europe and East Asia, eight countries in all. Using a mixed methodology, our research examined health and healthcare systems in order to chart the macro landscape of care provision and delivery. However, the core of our study was ethnographic research with older people, and their formal (clinical) and informal (family and friends) caregivers in their own homes and communities. Data from this study were organized and analyzed to produce a variety of tools that provide insight into the market for consumption by teams within the Digital Health Group. As the results of the research were driven into the Digital Health Group and other groups within Intel, it became clear that the Global Aging Experience Study possessed what we term ethnographic liquidity, meaning that the data, tools, and insights developed in the study have layers of utility, a long shelf life, and lend themselves to repeated and consistent use within and beyond the Digital Health Group

Plasma Composition Measurements in an Active Region from Solar Orbiter/SPICE and Hinode/EIS

A key goal of the Solar Orbiter mission is to connect elemental abundance measurements of the solar wind enveloping the spacecraft with extreme-UV (EUV) spectroscopic observations of their solar sources, but this is not an easy exercise. Observations from previous missions have revealed a highly complex picture of spatial and temporal variations of elemental abundances in the solar corona. We have used coordinated observations from Hinode and Solar Orbiter to attempt new abundance measurements with the Spectral Imaging of the Coronal Environment (SPICE) instrument, and benchmark them against standard analyses from the EUV Imaging Spectrometer (EIS). We use observations of several solar features in active region (AR) 12781 taken from an Earth-facing view by EIS on 2020 November 10, and SPICE data obtained one week later on 2020 November 17, when the AR had rotated into the Solar Orbiter field of view. We identify a range of spectral lines that are useful for determining the transition region and low-coronal-temperature structure with SPICE, and demonstrate that SPICE measurements are able to differentiate between photospheric and coronal magnesium/neon abundances. The combination of SPICE and EIS is able to establish the atmospheric composition structure of a fan loop/outflow area at the AR edge. We also discuss the problem of resolving the degree of elemental fractionation with SPICE, which is more challenging without further constraints on the temperature structure, and comment on what that can tell us about the sources of the solar wind and solar energetic particles

From practice to field:a multi-level model of practice-driven institutional change

This article develops a model of practice-driven institutional change - or change that originates in the everyday work of individuals but results in a shift in field-level logic. In demonstrating how improvisations at work can generate institutional change, we attend to the earliest moments of change, which extant research has neglected; and we contrast existing accounts that focus on active entrepreneurship and the contested nature of change. We outline the specific mechanisms by which change emerges from everyday work, becomes justified, and diffuses within an organization and field, as well as precipitating and enabling dynamics that trigger and condition these mechanisms. © Academy of Management Journal

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

From people to prototypes and products: ethnographic liquidity and the Intel Global Aging experience study

This article documents how a large-scale, multi-site, ethnographic research project into aging populations, the Global Aging Experience Study, led to the development of concepts, product prototypes, and products for the independent living market. Successfully leveraging the output of ethnographic research within large organizations and product groups is often fraught with challenges. Ethnographic research produced within an industry context can be difficult for an organization to thoroughly capitalize on. However, careful research design and sound knowledge transfer activities can produce highly successful outcomes that can be thoroughly absorbed into an organization, and the data can lend itself to re-analysis. Our research was conducted by the Product Research and Innovation Team in the Intel Digital Health Group, and the work was done in Europe and East Asia, eight countries in all. Using a mixed methodology, our research examined health and healthcare systems in order to chart the macro landscape of care provision and delivery. However, the core of our study was ethnographic research with older people, and their formal (clinical) and informal (family and friends) caregivers in their own homes and communities. Data from this study were organized and analyzed to produce a variety of tools that provide insight into the market for consumption by teams within the Digital Health Group. As the results of the research were driven into the Digital Health Group and other groups within Intel, it became clear that the Global Aging Experience Study possessed what we term ethnographic liquidity, meaning that the data, tools, and insights developed in the study have layers of utility, a long shelf life, and lend themselves to repeated and consistent use within and beyond the Digital Health Group

Technology and Independent Living: The Global Aging Experience Project

The abstract is included in the text

Distribution and genetic diversity of the Endangered Abbott’s duiker Cephalophus spadix in the Udzungwa Mountains, Tanzania

Abbott’s duiker Cephalophus spadix is a forest antelope endemic to a very few highland forests in Tanzania. Apparently extinct over much of its historical range, the species is listed as Endangered by the International Union for Conservation of Nature based on its rarity and its known current distribution in only 5 isolated upland areas: Kilimanjaro, Southern Highlands, West Usambara, Rubeho and Udzungwa Mountains. In contrast to the situation in the rest of its range, Abbott’s duiker is relatively well documented and locally abundant in parts of the Udzungwa Mountains, which may now be the only stronghold for the species. We review the distribution of Abbott’s duiker within the Udzungwa Mountains and present new information based on the non-invasive genetic identification of dung piles collected from the majority of forest blocks between 2006 and 2010 (73 confirmed dung samples). Our results include new records from outlying forest blocks where the presence of Abbott’s duiker was previously unknown. Moreover, we present the first population-level analysis of genetic structure and diversity in this endangered species based on nuclear microsatellites and mitochondrial sequence data. While these genetic results are limited due to small sample sizes, they indicate differentiation from other Abbott’s duiker populations, as well as low genetic diversity relative to sympatric antelope species. Finally, we discuss threats to Abbott’s duiker and identify broad trends within the differently managed Udzungwa Mountain forests, and elsewhere, that suggest potentially successful conservation strategies for this neglected species