Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium

Several studies have reported a decline in incidence of dementia which may have large implications for the projected burden of disease, and provide important guidance to preventive efforts. However, reports are conflicting or inconclusive with regard to the impact of gender and education with underlying causes of a presumed declining trend remaining largely unidentified. The Alzheimer Cohorts Consortium aggregates data from nine international population-based cohorts to determine changes in the incidence of dementia since 1990. We will employ Poisson regression models to calculate incidence rates in each cohort and Cox proportional hazard regression to compare 5-year cumulative hazards across study-specific epochs. Finally, we will meta-analyse changes per decade across cohorts, and repeat all analysis stratified by sex, education and APOE genotype. In all cohorts combined, there are data on almost 69,000 people at risk of dementia with the range of follow-up years between 2 and 27. The average age at baseline is similar across cohorts ranging between 72 and 77. Uniting a wide range of disease-specific and methodological expertise in research teams, the first analyses within the Alzheimer Cohorts Consortium are underway to tackle outstanding challenges in the assessment of time-trends in dementia occurrence

Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium

OBJECTIVE: To determine changes in the incidence of dementia between 1988 and 2015. METHODS: This analysis was performed in aggregated data from individuals >65 years of age in 7 population-based cohort studies in the United States and Europe from the Alzheimer Cohort Consortium. First, we calculated age- and sex-specific incidence rates for all-cause dementia, and then defined nonoverlapping 5-year epochs within each study to determine trends in incidence. Estimates of change per 10-year interval were pooled and results are presented combined and stratified by sex. RESULTS: Of 49,202 individuals, 4,253 (8.6%) developed dementia. The incidence rate of dementia increased with age, similarly for women and men, ranging from about 4 per 1,000 person-years in individuals aged 65-69 years to 65 per 1,000 person-years for those aged 85-89 years. The incidence rate of dementia declined by 13% per calendar decade (95% confidence interval [CI], 7%-19%), consistently across studies, and somewhat more pronouncedly in men than in women (24% [95% CI 14%-32%] vs 8% [0%-15%]). CONCLUSION: The incidence rate of dementia in Europe and North America has declined by 13% per decade over the past 25 years, consistently across studies. Incidence is similar for men and women, although declines were somewhat more profound in men. These observations call for sustained efforts to finding the causes for this decline, as well as determining their validity in geographically and ethnically diverse populations

Large-scale volumetric flow measurement in a pure thermal plume by dense tracking of helium-filled soap bubbles

We present a spatially and temporally highly resolved flow measurement covering a !arge volume (~o.6 m3) in a pure thermal plume in air. The thermal plume develops above an extended heat source and is characterized by moderate velocities (U~0.35 m/s) with a Reynolds number of Re~500 and a Rayleigh number of Ra~100000. We demonstrate the requirements and capa bilities of the measurement equipment and the particle tracking approach to be able to probe measurement volumes up to and beyond one cubic meter. The use of !arge tracer particles (300 µm), helium-filled soap bubbles (HFSBs), is crucial and yields high particle image quality over large-volume depths when illuminated with arrays of pulsed high-power LEDs. The experimental limitations of the HFSBs-their limited lifetime and their intensity loss over time-are quantified. The HFSBs' uniform particle images allows an accurate reconstruction of the flow using Shake-The-Box particle tracking with high partlcle concentrations up to 0.1 particles per pixel. This enables tracking of up to 275,000 HFSBs simultaneously. After interpolating the scattered data onto a regular grid with a Navier-Stokes regularization, the velocity field of the thermal plume reveals a multitude of vortices with a smooth temporal evolution and a remarkable coherence in time (see animation, supplementary data). Acceleration fields are also derived from interpolated particle tracks and complement the flow measurement. Additionally, the flow map, the basis of a !arge dass of Lagrangian coherent structures, is computed directly from observed particle tracks. We show entrainment regions and coherent vortices of the thermal plume in the flow map and compute fields of the finite-time Lyapunov exponent