Fungal inoculation effect on post-harvest sugarcane residue decomposition under field conditions

Fungal inoculation effect on post-harvest sugarcane residue (SCR) decomposition in field conditions was studied. In vitro interaction between selected fungi was determined by direct confrontation. Mycelial growth response to different concentrations of herbicides and urea was also assessed. Fungal combinations did not show inhibitory effects. Bjerkandera sp. Y-HHM2 and Myrothecium sp. S-3.20 growth decreased in 2.4-D agar plates. However, Pleurotus sp. Y- RN3 showed a stimulation in 10 ppm 2.4-D agar plates. The biggest growth in ametrine supplemented cultures was observed in Pleurotus sp. Y-RN3. Evaluation of increasing urea concentrations on mycelial growth showed that 5,000 ppm significantly inhibits mycelial growth. The field assay under rainfed condition showed that post-harvest SCR decomposition rate significantly increases in Y-HHM2, Y-RN3 and Y-HHM2/Y-RN3/S-3.20 treatments. This is the first report on the capability of Bjerkandera sp. Y-HHM2 and Pleurotus sp. Y-RN3 to accelerate post-harvest SCR decomposition in rainfed conditions at field scale, suggesting that these fungi might be useful tools in the sugarcane crop system.Fil: Maza, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigaciones Agropecuarias. Instituto de Investigación Animal del Chaco Semiárido; Argentina. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia. Sanidad Vegetal. Cátedra Fitopatología; ArgentinaFil: Medina, M.. Gobierno de Tucumán. Ministerio de Desarrollo Productivo. Estación Experimental Agroindustrial Obispo Colombres; ArgentinaFil: Plasencia, Adriana María. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; ArgentinaFil: Amoroso, Maria Julia del R.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; ArgentinaFil: Yasem, Marta Graciela. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia. Sanidad Vegetal. Cátedra Fitopatología; Argentin

Gene expression profiles induced by E6 from non-European HPV18 variants reveals a differential activation on cellular processes driving to carcinogenesis

AbstractCervical cancer in developed countries remains as a major concern on public health policies due to incidence and mortality rates. Persistent infection with high risk human papillomavirus is a necessary etiological agent in the progression to invasive cervical carcinoma. A proposed hypothesis is the association between more aggressive HPV variants and the risk to develop cervical cancer. In order to have a global perspective in terms of cellular transcripts and molecular pathways affected by HPV18 E6 intratype variants; we conducted a genome wide analysis of gene expression. Our results show that E6 derived from non-European variants are able to up-regulate cellular transcripts associated to the hallmarks of cancer; such as cell cycle, migration, Wnt pathway and mTor signaling. Moreover, we were able to show that HPV18 E6 from African variant had a major effect on cellular processes such as cell cycle and migration as confirmed by functional studies

Libro: Las Ciencias Políticas y Sociales ante Contingencias de Amplio Impacto. Incógnitas y Propuestas

Ciencia Política, Administración Pública, Política y Gobierno, y Políticas Públicas. Licencia Creative Commons License 3.0 Reconocimiento-No Comercial-Sin Obras Derivadas. Usted es libre de copiar, distribuir y comunicar públicamente la obra bajo las condiciones siguientes: Reconocimiento - Debe reconocer los créditos de la obra de la manera especificada por el autor o el licenciador (pero no de una manera que sugiera que tiene su apoyo o apoyan el uso que hace de su obra). No comercial - No puede utilizar esta obra para fines comerciales. Sin obras derivadas - No se puede alterar, transformar o generar una obra derivada a partir de esta obra.Se analizan desde una perspectiva internacional a interdisciplinaria las vertientes, problemas, incógnitas y propuestas ante una nueva realidad o normalidad, resultado y consecuencia de la pandemia que se vive de manera contemporánea, de tal manera que la problematización abordada realimente propuestas, acciones y rutas adecuadas y satisfactorias que permitan la construcción de futuros promisorios.Academia Internacional de Ciencias Político-Administrativas y Estudios de Futuro, A.C. (IAPAS por sus siglas en inglés)

Considerations on diagnosis and surveillance measures of PTEN hamartoma tumor syndrome : clinical and genetic study in a series of Spanish patients

Altres ajuts: European Regional Development Fund; Federación Española de Enfermedades Raras (FEDER); European Social Fund (ESF).Background: The limited knowledge about the PTEN hamartoma tumor syndrome (PHTS) makes its diagnosis a challenging task. We aimed to define the clinical and genetic characteristics of this syndrome in the Spanish population and to identify new genes potentially associated with the disease. Results: We reviewed the clinical data collected through a specific questionnaire in a series of 145 Spanish patients with a phenotypic features compatible with PHTS and performed molecular characterization through several approaches including next generation sequencing and whole exome sequencing (WES). Macrocephaly, mucocutaneous lesions, gastrointestinal polyposis and obesity are prevalent phenotypic features in PHTS and help predict the presence of a PTEN germline variant in our population. We also find that PHTS patients are at risk to develop cancer in childhood or adolescence. Furthermore, we observe a high frequency of variants in exon 1 of PTEN, which are associated with renal cancer and overexpression of KLLN and PTEN. Moreover, WES revealed variants in genes like NEDD4 that merit further research. Conclusions: This study expands previously reported findings in other PHTS population studies and makes new contributions regarding clinical and molecular aspects of PHTS, which are useful for translation to the clinic and for new research lines