Scrivere la LIS con il Sign Writing. Manuale introduttivo

Abstract not availableQuesto manuale nasce da un\u27intuizione, quella di poter utilizzare un sistema per trascrivere la Lingua dei Segni Italiana (LIS), adattando ai segni italiani il Sign Writing, ideato nel 1995 da Valerie Sutton (1995) e proposto come "un alfabeto per scrivere le lingue dei segni". La LIS infatti, come le altre lingue dei segni, non ha una corrispettiva forma scritta ed è stata tramandata di generazione in generazione dalla comunità sorda. La mancanza di una forma scritta, del resto comune a molte altre lingue, ha avuto tutta una serie di implicazioni nella storia della comunità sorda e la possibilità di utilizzare un sistema di trascrizione - come ha detto Valerie Sutton - può aprire nuove frontiere della comunicazione per i segnanti. L\u27attuale generazione di persone sorde adulte, che sta imparando a leggere e a scrivere le lingue segnate per la prima volta, sta creando la base per il lavoro delle generazioni future

Unità Lessematiche e Strutture di Grande Iconicità nella Lingua dei Segni Italiana (LIS): nuovi dati e nuove metodologie di analisi.

NON REPRINTInternational audienceIn this paper we deal with a still unresolved question in the study of LIS: what are the constituent units of the lexicon, and how much are comparable to those typical of spoken languages. The question is linked to the existence, in the signed discourse, of two main types of referring expressions: Lexematic Units (ULs) and Structures of Great Iconicity (SGIs). Making use of 5 different texts transcribed with SignWriting (SW), we explored the nature, the stability and/or the variability of sign shapes and of correspondences of meaning. We sampled the texts for different ways to express 10 entities/actions, and subsequently we asked their authors whether or not there is a "citational form", with an own autonomy for those same entities. The results show recurrent patterns in the selected expressive forms, and these include both ULs (less frequent) and SGIs (more present). Contrary to the assumption of most previous research, there are strong regularities in the elements that make up the SGI and the actual compositional choice. This fact highlights the need to include the SGI among the constituent units of LIS, suggesting to review the modeling of the lexicon of LIS (and of LS in general), identifying the most appropriate constructs that take into account the specific iconic and multilinear features of LS.Dans cet article, nous affrontons une question non encore résolue dans l'étude de la LIS: quels sont les éléments constitutifs du lexique, et dans quelle mesure sont-ils comparables à ceux des langues parlées. La question est liée à l'existence, dans un discours signé, de deux principaux types d'expressions référentielles: les Unités lexématiques (UL) et les Structures de grande iconicité (SGI). En utilisant 5 textes codifiés avec SignWriting (SW), nous avons exploré la typologie, la stabilité et/ou la variabilité des formes de Signes et des correspondances forme/signification. Nous avons recherché dans les textes les différentes façons d'exprimer 10 entités/actions, puis ensuite demander aux auteurs s’il existe une forme "citationnelle", dotée d’une autonomie de sens pour ces mêmes entités. Les résultats font apparaître des schémas récurrents dans les formes expressives identifiées et celles-ci comprennent à la fois des UL (moins fréquentes) et des SGI (plus présentes). Contrairement aux hypothèses d’une grande partie des travaux de recherche, on constate de fortes régularités dans les éléments qui composent les SGI et dans les choix de composition. Cela souligne la nécessité d'inclure la SGI parmi les unités constituantes de la LIS, et suggère qu’il faut revoir en profondeur les modélisations du lexique de la LIS (et des LS en général), en repérant les constructions mieux adaptées afin de tenir compte des caractéristiques iconiques spécifiques des LS.In questo contributo affrontiamo una questione tuttora irrisolta nello studio della LIS: quali siano le unità costitutive del lessico, e quanto siano paragonabili a quelle proprie delle lingue vocali. La questione è legata all'esistenza, nel discorso segnato, di due tipi principali di espressioni referenziali: le Unità Lessematiche (UL) e le Strutture di Grande Iconicità (SGI). Avvalendoci di 5 diversi testi codificati con SignWriting (SW), abbiamo esplorato la tipologia, la stabilità e/o la variabilità di forme segniche e corrispondenze forma-significato. Abbiamo ricercato nei testi i diversi modi di esprimere 10 entità/azioni per poi chiedere agli autori se esista o no una forma "citazionale", dotata di autonomia di senso per quelle stesse entità. I risultati evidenziano pattern ricorrenti nelle forme espressive individuate e queste comprendono sia UL (meno frequenti) che SGI (più presenti). Contrariamente a quanto ritenuto in gran parte delle ricerche, si osservano forti regolarità negli elementi che compongono le SGI e nelle scelte di composizione. Ciò evidenzia la necessità di includere le SGI fra le unità costitutive della LIS, suggerendo di rivedere in profondità le modellizazioni del lessico della LIS (e delle LS in genere), individuando costrutti più appropriati che tengano conto dei tratti iconici e multilineari specifici delle LS

Pulmonary and mediastinal paragangliomas: Rare endothoracic malignancies with challenging diagnosis and treatment

Background: Pulmonary and mediastinal paragangliomas are rare tumors that may have neuroendocrine activity or be non-functional, incidental, in asymptomatic patients, or causing mass effect symptoms. Although being low-grade tumors, they can display an aggressive behaviour, developing local infiltration and distant metastases. We report our experience with three endothoracic paragangliomas and a Literature review, to point out diagnostic difficulties and problems related to surgical treatment. Methods: From 2009 to 2017, we treated 3 patients with histological diagnosis of paraganglioma: 2 pulmonary, 1 mediastinal. No one presented catecholamine-secreting syndromes; pulmonary cases were asymptomatic, while the mediastinal one had aspecific cough and dyspnea. Imaging diagnosis was based on chest computerized tomography (CT) and magnetic resonance imaging (MRI) scan. No patient had preoperative histological diagnosis. Intraoperative pathological examination was suggestive for malignancy: in pulmonary cases, wedge resection and lobectomy were performed; the middle mediastinal mass was completely removed after challenging dissection, isolation and section of numerous vascular pedicles. Results: Postoperative course was uneventful in all cases. No patient received adjuvant treatments. At a median follow-up of 47 months (range, 6-102 months), two patients are alive, without local or distant recurrence; one patient died 6 months after surgery, due to disease progression. Conclusions: Endothoracic paragangliomas, rare and often asymptomatic tumors, are of difficult diagnosis and should be considered malignant tumors, due to the potential aggressive behaviour of cases with high mitotic index and the frequent possibility of recurrence and metastases. Surgical resection is the treatment of choice and careful intraoperative manipulation is recommended, due to the high vascularity of these tumors, to prevent complications. After complete excision, long-term prognosis is generally good. However, even after surgical removal, a close, periodical and life-long follow-up is mandatory

HSF1 is a prognostic determinant and therapeutic target in intrahepatic cholangiocarcinoma

Background Intrahepatic cholangiocarcinoma (iCCA) is a lethal primary liver tumor characterized by clinical aggressiveness, poor prognosis, and scarce therapeutic possibilities. Therefore, new treatments are urgently needed to render this disease curable. Since cumulating evidence supports the oncogenic properties of the Heat Shock Factor 1 (HSF1) transcription factor in various cancer types, we investigated its pathogenetic and therapeutic relevance in iCCA.MethodsLevels of HSF1 were evaluated in a vast collection of iCCA specimens. The effects of HSF1 inactivation on iCCA development in vivo were investigated using three established oncogene-driven iCCA mouse models. In addition, the impact of HSF1 suppression on tumor cells and tumor stroma was assessed in iCCA cell lines, human iCCA cancer-associated fibroblasts (hCAFs), and patient-derived organoids. Results Human preinvasive, invasive, and metastatic iCCAs displayed widespread HSF1 upregulation, which was associated with a dismal prognosis of the patients. In addition, hydrodynamic injection of a dominant-negative form of HSF1 (HSF1dn), which suppresses HSF1 activity, significantly delayed cholangiocarcinogenesis in AKT/NICD, AKT/YAP, and AKT/TAZ mice. In iCCA cell lines, iCCA hCAFs, and patient-derived organoids, administration of the HSF1 inhibitor KRIBB-11 significantly reduced proliferation and induced apoptosis. Cell death was profoundly augmented by concomitant administration of the Bcl-xL/Bcl2/Bcl-w inhibitor ABT-263. Furthermore, KRIBB-11 reduced mitochondrial bioenergetics and glycolysis of iCCA cells. Conclusions The present data underscore the critical pathogenetic, prognostic, and therapeutic role of HSF1 in cholangiocarcinogenesis

TXS 0506+056 with Updated IceCube Data

Past results from the IceCube Collaboration have suggested that the blazar TXS 0506+056 is a potential source of astrophysical neutrinos. However, in the years since there have been numerous updates to event processing and reconstruction, as well as improvements to the statistical methods used to search for astrophysical neutrino sources. These improvements in combination with additional years of data have resulted in the identification of NGC 1068 as a second neutrino source candidate. This talk will re-examine time-dependent neutrino emission from TXS 0506+056 using the most recent northern-sky data sample that was used in the analysis of NGC 1068. The results of using this updated data sample to obtain a significance and flux fit for the 2014 TXS 0506+056 "untriggered" neutrino flare are reported

Galactic Core-Collapse Supernovae at IceCube: “Fire Drill” Data Challenges and follow-up

The next Galactic core-collapse supernova (CCSN) presents a once-in-a-lifetime opportunity to make astrophysical measurements using neutrinos, gravitational waves, and electromagnetic radiation. CCSNe local to the Milky Way are extremely rare, so it is paramount that detectors are prepared to observe the signal when it arrives. The IceCube Neutrino Observatory, a gigaton water Cherenkov detector below the South Pole, is sensitive to the burst of neutrinos released by a Galactic CCSN at a level >10σ. This burst of neutrinos precedes optical emission by hours to days, enabling neutrinos to serve as an early warning for follow-up observation. IceCube\u27s detection capabilities make it a cornerstone of the global network of neutrino detectors monitoring for Galactic CCSNe, the SuperNova Early Warning System (SNEWS 2.0). In this contribution, we describe IceCube\u27s sensitivity to Galactic CCSNe and strategies for operational readiness, including "fire drill" data challenges. We also discuss coordination with SNEWS 2.0

All-Energy Search for Solar Atmospheric Neutrinos with IceCube

The interaction of cosmic rays with the solar atmosphere generates a secondary flux of mesons that decay into photons and neutrinos – the so-called solar atmospheric flux. Although the gamma-ray component of this flux has been observed in Fermi-LAT and HAWC Observatory data, the neutrino component remains undetected. The energy distribution of those neutrinos follows a soft spectrum that extends from the GeV to the multi-TeV range, making large Cherenkov neutrino telescopes a suitable for probing this flux. In this contribution, we will discuss current progress of a search for the solar neutrino flux by the IceCube Neutrino Observatory using all available data since 2011. Compared to the previous analysis which considered only high-energy muon neutrino tracks, we will additionally consider events produced by all flavors of neutrinos down to GeV-scale energies. These new events should improve our analysis sensitivity since the flux falls quickly with energy. Determining the magnitude of the neutrino flux is essential, since it is an irreducible background to indirect solar dark matter searches

Multiplicity of TeV muons in extensive air showers detected with IceTop and IceCube

We report on an analysis of the high-energy muon component in near-vertical extensive air showers detected by the surface array IceTop in coincidence with the in-ice array of the IceCube Neutrino Observatory. In the coincidence measurement, the predominantly electromagnetic signal measured by IceTop is used to estimate the cosmic-ray primary energy, and the energy loss of the muon bundle in the deep in-ice array is used to estimate the number of muons in the shower with energies above 500 GeV (“TeV muons”). The average multiplicity of these TeV muons is determined for cosmic-ray energies between 2.5 PeV and 100 PeV assuming three different hadronic interaction models: Sibyll 2.1, QGSJet-II.04, and EPOS-LHC. For all models considered, the results are found to be in good agreement with the expectations from simulations. A tension exists, however, between the high-energy muon multiplicity and other observables; most importantly the density of GeV muons measured by IceTop using QGSJet-II.04 and EPOS-LHC