Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer’s amyloid, tau and FDG PET status

Plasma phosphorylated-tau181 (p-tau181) showed the potential for Alzheimer’s diagnosis and prognosis, but its role in detecting cerebral pathologies is unclear. We aimed to evaluate whether it could serve as a marker for Alzheimer’s pathology in the brain. A total of 1189 participants with plasma p-tau181 and PET data of amyloid, tau or FDG PET were included from ADNI. Cross-sectional relationships of plasma p-tau181 with PET biomarkers were tested. Longitudinally, we further investigated whether different p-tau181 levels at baseline predicted different progression of Alzheimer’s pathological changes in the brain. We found plasma p-tau181 significantly correlated with brain amyloid (Spearman ρ = 0.45, P 18.85 pg/ml) at baseline had a higher risk of pathological progression in brain amyloid (HR: 2.32, 95%CI 1.32–4.08) and FDG PET (3.21, 95%CI 2.06–5.01) status. Plasma p-tau181 may be a sensitive screening test for detecting brain pathologies, and serve as a predictive biomarker for Alzheimer’s pathophysiology

Clinical Effectiveness of Listerine\u3csup\u3eR\u3c/sup\u3e and Viadent\u3csup\u3eR\u3c/sup\u3e Mouthrinses on Bacterial Plaque and Gingivitis

The purpose of this investigation was to determine the effects of two commercial mouth rinses, ListerineR and ViadentR, on bacterial plaque and gingivitis. over a sixweek period, 24 adults, ages 18-41, were examined for the amount of bacterial plaque and level of gingivitis using Silness and toe\u27s Plaque Index (PLI) and Gingival Index (GI). At the beginning of each two week period, subjects were examined for the amount of plaque and level of gingivitis and given a different mouthrinse: appointment one--viadentR (mouthrinse A), appointment two--placebo mouthrinse (mouthrinse B), and appointment three--ListerineR (mouthrinse C). Additionally, subjects were given oral and written mouthrinsing instructions at each appointment. A double-blind, cross-over design was used in this experimental pre-test/post-test research study. Results were tabulated on the basis of change in the mean Plaque and Gingival Index scores. Data were examined using a one-way analysis of variance and Tukey\u27s studentized Range Test to determine if any statistically significant differences existed in the mean GI scores and PLI scores throughout all four appointments. Additionally, a Paired-Difference t-test was applied to data to determine if the independent variables, ViadentR mouthrinse and ListerineR mouthrinse, had a statistically significant effect on the dependent variables, gingival inflammation and bacterial plaque. Results showed that rinsing with either ViadentR or ListerineR mouthrinse as an adjunct to routine oral hygiene had no statistically significant effect on the level of gingivitis or the amount of bacterial plaque

The Political Economy of the Vanishing Marginals: Tiebout Sorting and the American Political System

An overview of our methodology and results suggests that there does exist a trend stationary pattern of increasing vote margins driven by traditional and expanded Tiebout Sorting. First, we have found a long-term trend stationary pattern of increasing vote margins. This was followed by the discovery that within a subset of the trend, 1942 to 1992, a blunt measurement of Tiebout Sorting through the application of urban-rural differences, soliciting information regarding age, class, gender, income, occupation, and race while measuring preferences for public goods through an individual's vote, was statistically significant. Finally, we identified evidence of Tiebout Sorting of both the traditional variety (sorting based on public goods provided) and the economic, but not ideological, portion of the expanded variety (spatial sorting by ideological and economic factors)

Guía para el abordaje nutricional de la población infantil y adolescente con diabetes tipo 1 y enfermedad celíaca

El proyecto de intervención consiste en el desarrollo de una “Guía para el abordaje nutricional de la población infantil y adolescente con diabetes tipo 1 y enfermedad celíaca que asiste al Hospital de Niños “Sor María Ludovica” de la ciudad de La Plata”. La misma será destinada a los familiares de la población mencionada. La diabetes mellitus tipo 1 (DM1) y la enfermedad celíaca (EC) son patologías con un origen genético común. Una mayor prevalencia de EC en los pacientes con DM1 respecto a la población general, evidencia esta asociación. A nivel mundial, entre el 1 al 10% de los niños, niñas y adolescentes con DM1 son diagnosticados a su vez con EC [1]. Esto, sumado al impacto que ambas condiciones presentan en la calidad de vida, convierte a la problemática en un interés para la salud pública. Enmarcado en este panorama, y ante la necesidad de proponer herramientas que contemplen los desafíos de ambas enfermedades, surge la propuesta de desarrollar una guía que tenga por objetivos principales ofrecer recomendaciones nutricionales e ideas de recetas que empleen alimentos alternativos a las premezclas, con el fin de aumentar el consumo de alimentos de buena calidad nutricional, con un alto contenido en fibra y de bajo índice glucémico; así como también, aumentar la adherencia al tratamiento nutricional y, consecuentemente, mejorar la calidad de vida de niños, niñas y adolescentes con DM1 y EC y sus familias.Licenciado en NutriciónUniversidad Nacional de La PlataFacultad de Ciencias Médica

Anthropometric traits and sport: study of pre-puberal children of Ravenna province.

After a general analysis of the level of sport participation in the school age population of the province of Ravenna, a study on anthropometric traits and motor tests was carried out on male and female children, 9-11 aged. The purpose of the present research was to investigate the relationship between sport activity and anthropometric or performance characteristics during childhood. As regards somatometric traits, sport practicing children did not show significant differences than non-sport practicing children, also if a possible positive effect of physical activity on the reduction of adiposity was suggested. Results of physiometric and motor ability tests pointed out an improvement in sport children. Physical activity contributes early to improve the physical abilities in childhood, but it appears that physical activityhad not yet influenced the physical development. The present study confirms the existence of a very weak nexus between these variables before puberty on children who maintain a medium-low level of habitual physical activity

Construct validation and test-retest reliability of a mealtime satisfaction questionnaire for retirement home residents

Mealtime satisfaction is an important component of quality of life (QOL) in residential care, yet there currently is no self-administered tool described in the literature. The purpose of this study is to investigate internal and test–retest reliability, and construct validity of a mealtime satisfaction questionnaire (MSQ) designed for residential care, more specifically retirement homes. A 15-item MSQ was developed and eligible participants from four retirement homes (n = 749) were invited to participate. The participation rate was 24% and the median age was 88 years for respondents. The internal consistency of the MSQ was high (Cronbach Alpha = 0.83) and the test–retest reliability was also high (Intraclass coefficient = 0.91, P <0.01). The MSQ was associated with a valid and reliable QOL instrument for older adults (Mann Whitney Test = 1595.5, P <0.01). The MSQ is reliable and is content and construct valid. QOL can be enriched by improving mealtime satisfaction in retirement homes