A hybrid small-world network : semi-physical model for large-scale wildland fires

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LESSONS LEARNT ON 3D PRINTING MICHELANGELO’S DAVID REPLICA

This paper reports and discusses the results of some experimental investigations carried out with the aim to identify the best conditions for a safe exposure of the 3D printed large-scale replica of Michelangelo’s David during its exhibition in the Italian Pavilion of the Expo 2020 Dubai.The whole project posed numerous challenges due to the dimension of the Michelangelo’s David (which is over seven metres high and weighs more than five ton). As a matter of fact, on the one hand, no standardized procedures have been still established to define accuracy and quality of 3D printing. On the other hand, the large-scale printing opens up new issues concerning the mechanical properties requested of the printing material and the printing set-up that is necessary to ensure the stability and durability of the printed replica.After a general picture of the whole project, thermal characterization of the material used to print the replica and mechanical tests of samples obtained form the replica are reported and discussed. Thermal characterisation showed that the stiffness of the material was strongly influenced by temperature and that it decreased continuously as this parameter increased. Mechanical tests showed a brittle behaviour, with a collapse load approximately 10 times higher than the internal loads resulting from the self-weight alone.The analyses here presented constitute some of the groundwork carried out for the realisation and installation of the 3D printed replica of Michelangelo’s David. This conceptualisation, considering both the extreme environmental conditions and the large-size of the replica, has been particularly challenging and the adopted procedure was useful to verify the different phases of the realisation of the replica.</p

Single Port Donor Nephrectomy

In 2007, Rane presented the first single port nephrectomy for a small non-functioning kidney at the World Congress of Endourology. Since that time, the use of single port surgery for nephrectomy has expanded to include donor nephrectomy. Over the next two years the technique was adopted for many others types of nephrectomies to include donor nephrectomy. We present our technique for single port donor nephrectomy using the Gelpoint device. We have successfully performed this surgery in over 100 patients and add this experience to our experience of over 1000 laparoscopic nephrectomies. With the proper equipment and technique, single port donor nephrectomy can be performed safely and effectively in the majority of live donors. We have found that our operative times and most importantly our transplant outcomes have not changed significantly with the adoption of the single port donor nephrectomy. We believe that single port donor nephrectomy represents a step forward in the care of living donors

From Predicting Solar Activity to Forecasting Space Weather: Practical Examples of Research-to-Operations and Operations-to-Research

The successful transition of research to operations (R2O) and operations to research (O2R) requires, above all, interaction between the two communities. We explore the role that close interaction and ongoing communication played in the successful fielding of three separate developments: an observation platform, a numerical model, and a visualization and specification tool. Additionally, we will examine how these three pieces came together to revolutionize interplanetary coronal mass ejection (ICME) arrival forecasts. A discussion of the importance of education and training in ensuring a positive outcome from R2O activity follows. We describe efforts by the meteorological community to make research results more accessible to forecasters and the applicability of these efforts to the transfer of space-weather research.We end with a forecaster "wish list" for R2O transitions. Ongoing, two-way communication between the research and operations communities is the thread connecting it all.Comment: 18 pages, 3 figures, Solar Physics in pres

Streamer Wave Events Observed in Solar Cycle 23

In this paper we conduct a data survey searching for well-defined streamer wave events observed by the Large Angle and Spectrometric Coronagraph (LASCO) on-board the Solar and Heliospheric Observatory (SOHO) throughout Solar Cycle 23. As a result, 8 candidate events are found and presented here. We compare different events and find that in most of them the driving CMEs ejecta are characterized by a high speed and a wide angular span, and the CME-streamer interactions occur generally along the flank of the streamer structure at an altitude no higher than the bottom of the field of view of LASCO C2. In addition, all front-side CMEs have accompanying flares. These common observational features shed light on the excitation conditions of streamer wave events. We also conduct a further analysis on one specific streamer wave event on 5 June 2003. The heliocentric distances of 4 wave troughs/crests at various exposure times are determined; they are then used to deduce the wave properties like period, wavelength, and phase speeds. It is found that both the period and wavelength increase gradually with the wave propagation along the streamer plasma sheet, and the phase speed of the preceding wave is generally faster than that of the trailing ones. The associated coronal seismological study yields the radial profiles of the Alfv\'en speed and magnetic field strength in the region surrounding the streamer plasma sheet. Both quantities show a general declining trend with time. This is interpreted as an observational manifestation of the recovering process of the CME-disturbed corona. It is also found that the Alfv\'enic critical point is at about 10 R$_\odot$ where the flow speed, which equals the Alfv\'en speed, is $\sim$ 200 km s$^{-1}$

Assessment of adulteration of cosmetics based on vegetable oils by GC-FID and lipid profile using direct infusion electrospray ionization mass spectrometry (ESI-MS)

CNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL E NÍVEL SUPERIORFAPPR - FUNDAÇÃO ARAUCÁRIA DE APOIO AO DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO DO PARANÁVegetable oils have properties that are beneficial to the human skin, and so, they are being used increasingly as ingredients of many cosmetic preparations; however, they are targets of adulteration. This study will evaluate the authenticity of Brazilian291224572465CNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL E NÍVEL SUPERIORFAPPR - FUNDAÇÃO ARAUCÁRIA DE APOIO AO DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO DO PARANÁCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL E NÍVEL SUPERIORFAPPR - FUNDAÇÃO ARAUCÁRIA DE APOIO AO DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO DO PARANÁsem informaçãosem informaçãosem informaçã

The Solar Eruption of 2017 September 10: Wavy with a Chance of Protons

High-resolution SUVI images reveal an interesting new picture of particle acceleration in powerful solar eruptions. Typically, powerful solar eruptions include a coronal wave component, as well the traditional CME and flare components. At low solar altitudes, coronal waves refract downward, toward the solar surface, because of the slower Alfv&eacute;n speeds at the base of the corona. The refracted wave plus the shock wave ahead of an intense CME allow for a two-step shock acceleration process that can result in relativistic or GLE particles. This mechanism may be particularly applicable to the first-to-arrive, prompt relativistic particles measured by the Fort Smith neutron monitor during GLE # 72 on 2017 September 10. &nbsp;</p

Cost-Effectiveness of Whole-Genome vs Whole-Exome Sequencing Among Children With Suspected Genetic Disorders

IMPORTANCE The diagnosis of rare diseases and other genetic conditions can be daunting due to vague or poorly defined clinical features that are not recognized even by experienced clinicians. Next-generation sequencing technologies, such as whole-genome sequencing (WGS) and whole-exome sequencing (WES), have greatly enhanced the diagnosis of genetic diseases by expanding the ability to sequence a large part of the genome, rendering a cost-effectiveness comparison between them necessary. OBJECTIVE To assess the cost-effectiveness of WGS compared with WES and conventional testing in children with suspected genetic disorders. DESIGN, SETTING, AND PARTICIPANTS In this economic evaluation, a bayesian Markov model was implemented from January 1 to June 30, 2023. The model was developed using data from a cohort of 870 pediatric patients with suspected genetic disorders who were enrolled and underwent testing in the Ospedale Pediatrico Bambino Gesù, Rome, Italy, from January 1, 2015, to December 31, 2022. The robustness of the model was assessed through probabilistic sensitivity analysis and value of information analysis. MAIN OUTCOMES AND MEASURES Overall costs, number of definitive diagnoses, and incremental cost-effectiveness ratios per diagnosis were measured. The cost-effectiveness analyses involved 4 comparisons: first-tier WGS with standard of care; first-tier WGS with first-tier WES; first-tier WGS with second-tier WES; and first-tier WGS with second-tier WGS. RESULTS The ages of the 870 participants ranged from 0 to 18 years (539 [62%] girls). The results of the analysis suggested that adopting WGS as a first-tier strategy would be cost-effective compared with all other explored options. For all threshold levels above €29 800 (US $32 408) per diagnosis that were tested up to €50 000 (US$54 375) per diagnosis, first-line WGS vs second-line WES strategy (ie, 54.6%) had the highest probability of being cost-effective, followed by first-line vs second-line WGS (ie, 54.3%), first-line WGS vs the standard of care alternative (ie, 53.2%), and first-line WGS vs first-line WES (ie, 51.1%). Based on sensitivity analyses, these estimates remained robust to assumptions and parameter uncertainty. CONCLUSIONS AND RELEVANCE The findings of this economic evaluation encourage the development of policy changes at various levels (ie, macro, meso, and micro) of international health systems to ensure an efficient adoption of WGS in clinical practice and its equitable access

The MeerKAT Fornax Survey

We present the science case and observations plan of the MeerKAT Fornax Survey, an HI and radio continuum survey of the Fornax galaxy cluster to be carried out with the SKA precursor MeerKAT. Fornax is the second most massive cluster within 20 Mpc and the largest nearby cluster in the southern hemisphere. Its low X-ray luminosity makes it representative of the environment where most galaxies live and where substantial galaxy evolution takes place. Fornax's ongoing growth makes it an excellent laboratory for studying the assembly of clusters, the physics of gas accretion and stripping in galaxies falling in the cluster, and the connection between these processes and the neutral medium in the cosmic web. We will observe a region of 12 deg$^2$ reaching a projected distance of 1.5 Mpc from the cluster centre. This will cover a wide range of environment density out to the outskirts of the cluster, where gas-rich in-falling groups are found. We will: study the HI morphology of resolved galaxies down to a column density of a few times 1e+19 cm$^{-2}$ at a resolution of 1 kpc; measure the slope of the HI mass function down to M(HI) 5e+5 M(sun); and attempt to detect HI in the cosmic web reaching a column density of 1e+18 cm$^{-2}$ at a resolution of 10 kpc.Comment: Proceedings of Science, "MeerKAT Science: On the Pathway to the SKA", Stellenbosch, 25-27 May 201