Development and implementation of a potential coronavirus disease 2019 (COVID-19) vaccine: A systematic review and meta-analysis of vaccine clinical trials.

Background: To date, there is no comprehensive systematic review and meta-analysis to assess the suitability of COVID-19 vaccines for mass immunization. The current systematic review and meta-analysis was conducted to evaluate the safety and immunogenicity of novel COVID-19 vaccine candidates under clinical trial evaluation and present a contemporary update on the development and implementation of a potential vaccines. Methods: For this study PubMed, MEDLINE, and Embase electronic databases were used to search for eligible studies on the interface between novel coronavirus and vaccine design until December 31, 2020. Results: We have included fourteen non-randomized and randomized controlled phase I-III trials. Implementation of a universal vaccination program with proven safety and efficacy through robust clinical evaluation is the long-term goal for preventing COVID-19. The immunization program must be cost-effective for mass production and accessibility. Despite pioneering techniques for the fast-track development of the vaccine in the current global emergency, mass production and availability of an effective COVID-19 vaccine could take some more time. Conclusion: Our findings suggest a revisiting of the reported solicited and unsolicited systemic adverse events for COVID-19 candidate vaccines. Hence, it is alarming to judiciously expose thousands of participants to COVID-19 candidate vaccines at Phase-3 trials that have adverse events and insufficient evidence on safety and effectiveness that necessitates further justification

The societal context of professional practice: Examining the impact of politics and economics on journalistic role performance across 37 countries

The impact of socio-political variables on journalism is an ongoing concern of comparative research on media systems and professional cultures. However, they have rarely been studied systematically across diverse cases, particularly outside Western democracies, and existing studies that compare western and non-western contexts have mainly focused on journalistic role conceptions rather than actual journalistic practice. Using journalistic role performance as a theoretical and methodological framework, this paper overcomes these shortcomings through a content analysis of 148,474 news stories from 365 print, online, TV, and radio outlets in 37 countries. We consider two fundamental system-level variables—liberal democracy and market orientation—testing a series of hypotheses concerning their influence on the interventionist, watchdog, loyal-facilitator, service, infotainment, and civic roles in the news globally. Findings confirm the widely asserted hypothesis that liberal democracy is associated with the performance of public-service oriented roles. Claims that market orientation reinforces critical and civic-oriented journalism show more mixed results and give some support to the argument that there are forms of “market authoritarianism” associated with loyalist journalism. The findings also show that the interventionist and infotainment roles are not significantly associated with the standard measures of political and economic structure, suggesting the need for more research on their varying forms across societies and the kinds of system-level factors that might explain them

Flowering dynamics and seed production of Arachis pintoi and Arachis repens in the brazilian cerrados.

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New perspectives on the passive treatment of ferruginous circumneutral mine waters in the UK

This paper examines major physico-chemical processes during the passive treatment of ferruginous circumneutral drainage from abandoned coal mines in the UK. Data collected over several years of studies on mine water treatment systems shed new light on the relative importance of hydraulics, settling velocity, Fe(II) oxidation rates and cascade aeration, which, in turn, informs the design of future systems. This paper demonstrates that (1) the complex settling behaviour of Fe(III) precipitates may be described by a first-order volumetric process and that settling rate is different for different mine waters; (2) the hydraulic efficiency (ratio of time to peak tracer concentration to nominal residence time) of the settling ponds studied was widely variable at low flow rates in comparison to constructed wetlands; (3) aeration cascades contribute dissolved oxygen and lead to a rise in pH due to CO2 degassing, which are very important in reducing the required time for iron oxidation and removal; (4) for at least 10 of the 30 sites examined, modelling of the rates of Fe(II) oxidation and particulate settling reveals that removal of iron is primarily dependent on settling rate; and (5) that substantial increases in pH can be brought about by forced aeration of mine water over several hours. Findings of this study apply to the majority of coal mine water treatment sites in the UK and may have broader application to other ferruginous waters with circumneutral pH or after treatment to increase pH