Using Speckle to Measure Tissue Dispersion in Optical Coherence Tomography

Tissue dispersion could be used as a marker of early disease changes to further improve the diagnostic potential of Optical Coherence Tomography (OCT). However, most methods to measure dispersion, described in the literature, rely on the presence of distinct and strong reflectors and are, therefore, rarely applicable in vivo. A novel technique has been developed which estimates the dispersion-induced resolution degradation from the image speckle and, as such, is applicable in situ. This method was verified experimentally ex vivo and was applied to the classification of a set of normal and cancerous colon OCT images resulting in 96% correct classificatio

52 km-long transmission link using a 50 Gb/s O-band silicon microring modulator co-packaged with a 1V-CMOS driver

We present an O-band silicon microring modulator with up to 50 Gb/s modulation rates, co-packaged with a 1V-CMOS driver in a dispersion un-compensated, transmission experiment through 52 km of standard single-mode fiber. The experimental results show 10(-9) error-rate operation with a negligible power penalty of 0.2 dB for 40 Gb/s and wide-open eye diagrams for 50 Gb/s data, corresponding to a record high bandwidth-distance product of 2600 Gb.km/s. A comparative analysis between the proposed transmitter assembly and a commercial LiNbO3 modulator revealed a moderate increase of 3.8 dB in power penalty, requiring only 20% of the driving voltage level used by the commercial modulator

A 160Gb/s (4x40) WDM O-band Tx subassembly using a 4-ch array of silicon rings co-packaged with a SiGe BiCMOS IC driver

We present a 400 (8×50) Gb/s-capable RM-based Si-photonic WDM O-band TxRx with 1.17nm channel spacing for high-speed optical interconnects and demonstrate successful 50Gb/s-NRZ TxRx operation achieving a ~4.5dB Tx extinction ratio under 2.15Vpp drive

4-channel 200 Gb/s WDM O-band silicon photonic transceiver sub-assembly

We demonstrate a 200G capable WDM O-band optical transceiver comprising a 4-element array of Silicon Photonics ring modulators (RM) and Ge photodiodes (PD) co-packaged with a SiGe BiCMOS integrated driver and a SiGe transimpedance amplifier (TIA) chip. A 4 x 50 Gb/s data modulation experiment revealed an average extinction ratio (ER) of 3.17 dB, with the transmitter exhibiting a total energy efficiency of 2 pJ/bit. Data reception has been experimentally validated at 50 Gb/s per lane, achieving an interpolated 10E-12 bit error rate (BER) for an input optical modulation amplitude (OMA) of -9.5 dBm and a power efficiency of 2.2 pJ/bit, yielding a total power efficiency of 4.2 pJ/bit for the transceiver, including heater tuning requirements. This electro-optic subassembly provides the highest aggregate data-rate among O-band RM-based silicon photonic transceiver implementations, highlighting its potential for next generation WDM Ethernet transceivers. (C) 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

O-Band silicon photonic transmitters for datacom and computercom interconnects

Today, the datacenter ecosystems are fueling the demand for novel transmitter (TX) technologies complying with the off-board, on-board, and chip-to-chip computing needs. This has set a new class of requirements for the TX infrastructure that should now offer multiple credentials, namely: high-speed, O-band operation for avoiding dispersion compensation in long distances, wavelength-division multiplexing (WDM) capabilities for higher throughput and multicasting/broadcasting support, and tight copackaging with low-power electronics. Silicon (Si) photonic TXs have been extensively studied toward high-speed and WDM TX engines targeting mainly C-band. Only a limited number of Si-Pho O-band TXs have been reported, however with <= 32 Gb/s/channel line-rate capabilities and with a WDM portfolio that has not been fully explored yet. In this paper, we introduce a novel silicon photonic high-speed O-band TX hardware platform that can meet the current datacom and computercom interconnect requirements. We demonstrate a ring modulator (RM) based four-channelWDMTX at 4 x 40 Gb/s non-return-to-zero (NRZ) operation that supports wavelength parallelism in unicast operation but can also pave the way toward WDM TX engines for the post-100 GbE TX era. Moreover, we present a broadband Si Mach-Zehnder modulator employed in a WDM modulation scheme of 2 x 25 Gb/s NRZ signals and demonstrate multicasting when combined with a 8x8 passive arrayed waveguide grating router (AWGR) wavelength router, addressing the broadcasting needs of traffic usually encountered in cache-coherent multisocket settings. Finally, we further demonstrate the tight synergy of O-band Si-RM modulators with high-speed CMOS electronics, presenting an RM-based TX assembly prototype employing a fully depleted silicon-on-insulator CMOS driver, delivering 50-Gb/s NRZ operation

Non-invasive optical interferometry for the assessment of biofilm growth in the middle ear

Otitis media (OM) is the most common illness in children in the United States. Three-fourths of children under the age of three have OM at least once. Children with chronic OM, including OM with effusion and recurrent OM, will often have conductive hearing loss and communication difficulties, and need surgical treatment. Recent clinical studies provide evidence that almost all chronic OM cases are accompanied by a bacterial biofilm behind the tympanic membrane (eardrum) and within the middle ear. Biofilms are typically very thin, and cannot be recognized using a regular otoscope. Here we demonstrate how optical low coherence interferometry (LCI) noninvasively depth-ranges into the middle ear to detect and quantify biofilm microstructure. A portable diagnostic system integrating LCI with a standard video otoscope was constructed and used to detect and quantify the presence of biofilms in a newly-developed pre-clinical animal model for this condition. Using a novel classification algorithm for acquired LCI data, the system identified the presence of a biofilm with 86% sensitivity and 90% specificity, compared to histological findings. This new information on the presence of a biofilm, its structure, and its response to antibiotic treatment, will not only provide better understanding of fundamental principles that govern biofilm formation, growth, and eradication, but may also provide much needed clinical data to direct and monitor protocols for the successful management of otitis media

Chip-to-chip interconnect for 8-socket direct connectivity using 25Gb/s O-band integrated transceiver and routing circuits

We present an O-band Chip-to-Chip Interconnect for 8-socket direct connectivity exploiting a Si-based Ring Modulator and a packaged PD-TIA connected over a Si-based 8×8 AWGR routing module. Eight routing scenarios are experimentally demonstrated at 25Gb/s revealing error-free operation

A 40 Gb/s chip-to-chip interconnect for 8-socket direct connectivity using integrated photonics

We present an O-band any-to-any chip-to-chip (C2C) interconnection at 40 Gb/s suitable for up to 8-socket direct connectivity in multi-socket server boards, utilizing integrated low-energy photonics for the transceiver and routing functions. The C2C interconnect exploits an Si-based ring modulator as its transmitter and a co-packaged photodiode/transimpedance amplifier enabled receiver interconnected over an 8 x 8 Si-based arrayed waveguide grating router, allowing for a single-hop flat-topology interconnection between eight nodes. A proof-of-concept demonstration of the C2C interconnect is presented at 25 and 40 Gb/s for eight possible routing scenarios, revealing clear eye diagrams at both data rates with extinction ratios of 4.8 +/- 0.3 and 4.38 +/- 0.31 dB, respectively, among the eight routed signals