362 research outputs found
Atroposelective formation of dibenz[c,e]azepines via intramolecular direct arylation with centre-axis chirality transfer
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T-cell depleted HLA-haploidentical HSCT in a child with neuromyelitis optica
Neuromyelitis optica is an immune-mediated disease characterized by a relapsing course, resulting in progressive disability. In children, given the long life expectancy, a disease-modifying treatment could be particularly desirable. Unfortunately, the currently available treatment strategies with this potential are scarce. Very limited data are available about the use of allogeneic hematopoietic stem cell transplantation (HSCT) for autoimmune neurological diseases. In this report, we present a pediatric case successfully treated with allogeneic HSCT from an HLA-haploidentical donor, after ex vivo TCR/CD19-depletion of the graft. To the best of our knowledge, this is the first case of a pediatric patient to benefit from such a treatment
Crowdsourced assessment of surgical skill proficiency in cataract surgery
OBJECTIVE: To test whether crowdsourced lay raters can accurately assess cataract surgical skills.
DESIGN: Two-armed study: independent cross-sectional and longitudinal cohorts.
SETTING: Washington University Department of Ophthalmology.
PARTICIPANTS AND METHODS: Sixteen cataract surgeons with varying experience levels submitted cataract surgery videos to be graded by 5 experts and 300+ crowdworkers masked to surgeon experience. Cross-sectional study: 50 videos from surgeons ranging from first-year resident to attending physician, pooled by years of training. Longitudinal study: 28 videos obtained at regular intervals as residents progressed through 180 cases. Surgical skill was graded using the modified Objective Structured Assessment of Technical Skill (mOSATS). Main outcome measures were overall technical performance, reliability indices, and correlation between expert and crowd mean scores.
RESULTS: Experts demonstrated high interrater reliability and accurately predicted training level, establishing construct validity for the modified OSATS. Crowd scores were correlated with (r = 0.865, p \u3c 0.0001) but consistently higher than expert scores for first, second, and third-year residents (p \u3c 0.0001, paired t-test). Longer surgery duration negatively correlated with training level (r = -0.855, p \u3c 0.0001) and expert score (r = -0.927, p \u3c 0.0001). The longitudinal dataset reproduced cross-sectional study findings for crowd and expert comparisons. A regression equation transforming crowd score plus video length into expert score was derived from the cross-sectional dataset (r
CONCLUSIONS: Crowdsourced rankings correlated with expert scores, but were not equivalent; crowd scores overestimated technical competency, especially for novice surgeons. A novel approach of adjusting crowd scores with surgery duration generated a more accurate predictive model for surgical skill. More studies are needed before crowdsourcing can be reliably used for assessing surgical proficiency
Multiple signatures of the JC polyomavirus in paired normal and altered colorectal mucosa indicate a link with human colorectal cancer, but not with cancer progression.
CUORE-0 results and prospects for the CUORE experiment
With 741 kg of TeO2 crystals and an excellent energy resolution of 5 keV
(0.2%) at the region of interest, the CUORE (Cryogenic Underground Observatory
for Rare Events) experiment aims at searching for neutrinoless double beta
decay of 130Te with unprecedented sensitivity. Expected to start data taking in
2015, CUORE is currently in an advanced construction phase at LNGS. CUORE
projected neutrinoless double beta decay half-life sensitivity is 1.6E26 y at 1
sigma (9.5E25 y at the 90% confidence level), in five years of live time,
corresponding to an upper limit on the effective Majorana mass in the range
40-100 meV (50-130 meV). Further background rejection with auxiliary bolometric
detectors could improve CUORE sensitivity and competitiveness of bolometric
detectors towards a full analysis of the inverted neutrino mass hierarchy.
CUORE-0 was built to test and demonstrate the performance of the upcoming CUORE
experiment. It consists of a single CUORE tower (52 TeO2 bolometers of 750 g
each, arranged in a 13 floor structure) constructed strictly following CUORE
recipes both for materials and assembly procedures. An experiment its own,
CUORE-0 is expected to reach a sensitivity to the neutrinoless double beta
decay half-life of 130Te around 3E24 y in one year of live time. We present an
update of the data, corresponding to an exposure of 18.1 kg y. An analysis of
the background indicates that the CUORE performance goal is satisfied while the
sensitivity goal is within reach.Comment: 10 pages, 3 figures, to appear in the proceedings of NEUTRINO 2014,
26th International Conference on Neutrino Physics and Astrophysics, 2-7 June
2014, held at Boston, Massachusetts, US
Status of the CUORE and results from the CUORE-0 neutrinoless double beta decay experiments
CUORE is a 741 kg array of TeO2 bolometers for the search of neutrinoless
double beta decay of 130Te. The detector is being constructed at the Laboratori
Nazionali del Gran Sasso, Italy, where it will start taking data in 2015. If
the target background of 0.01 counts/keV/kg/y will be reached, in five years of
data taking CUORE will have a 1 sigma half life sensitivity of 10E26 y. CUORE-0
is a smaller experiment constructed to test and demonstrate the performances
expected for CUORE. The detector is a single tower of 52 CUORE-like bolometers
that started taking data in spring 2013. The status and perspectives of CUORE
will be discussed, and the first CUORE-0 data will be presented.Comment: 7 pages, 4 figures, to be published in the proceedings of ICHEP 2014,
37th International Conference on High Energy Physics, Valencia (Spain) 2-9
July 201
Measurement of the Two-Neutrino Double Beta Decay Half-life of Te with the CUORE-0 Experiment
We report on the measurement of the two-neutrino double beta decay half-life
of Te with the CUORE-0 detector. From an exposure of 33.4 kgy of
TeO, the half-life is determined to be = [8.2 0.2
(stat.) 0.6 (syst.)] 10y. This result is obtained after a
detailed reconstruction of the sources responsible for the CUORE-0 counting
rate, with a specific study of those contributing to the Te
neutrinoless double beta decay region of interest.Comment: Corrected typo in section 9: 3.43E5 Bq/kg should have read 3.43E-5
Bq/k
CUORE and beyond: bolometric techniques to explore inverted neutrino mass hierarchy
The CUORE (Cryogenic Underground Observatory for Rare Events) experiment will
search for neutrinoless double beta decay of Te. With 741 kg of TeO
crystals and an excellent energy resolution of 5 keV (0.2%) at the region of
interest, CUORE will be one of the most competitive neutrinoless double beta
decay experiments on the horizon. With five years of live time, CUORE projected
neutrinoless double beta decay half-life sensitivity is y
at ( y at the 90% confidence level), which
corresponds to an upper limit on the effective Majorana mass in the range
40--100 meV (50--130 meV). Further background rejection with auxiliary light
detector can significantly improve the search sensitivity and competitiveness
of bolometric detectors to fully explore the inverted neutrino mass hierarchy
with Te and possibly other double beta decay candidate nuclei.Comment: Submitted to the Proceedings of TAUP 2013 Conferenc
Exploring the Neutrinoless Double Beta Decay in the Inverted Neutrino Hierarchy with Bolometric Detectors
Neutrinoless double beta decay (0nubb) is one of the most sensitive probes
for physics beyond the Standard Model, providing unique information on the
nature of neutrinos. In this paper we review the status and outlook for
bolometric 0nubb decay searches. We summarize recent advances in background
suppression demonstrated using bolometers with simultaneous readout of heat and
light signals. We simulate several configurations of a future CUORE-like
bolometer array which would utilize these improvements and present the
sensitivity reach of a hypothetical next-generation bolometric 0nubb
experiment. We demonstrate that a bolometric experiment with the isotope mass
of about 1 ton is capable of reaching the sensitivity to the effective Majorana
neutrino mass (|mee|) of order 10-20 meV, thus completely exploring the
so-called inverted neutrino mass hierarchy region. We highlight the main
challenges and identify priorities for an R&D program addressing them.Comment: 22 pages, 15 figures, submitted to EPJ
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