Inspiracje intelektualne teorii kultury i społeczeństwa Herberta Marcusego

"Podejmując próbę całościowej oceny czy też syntetycznego ujęcia teoretycznych i praktycznych osiągnięć Instytutu Badań Społecznych, szerzej znanego jako Szkoła Frankfurcka, historyk idei staje przed niebagatelnym problemem zarówno natury metodologicznej, jak i merytorycznej. Z perspektywy początku XXI wieku (chociaż – jak powiadał M. Foucault – ów moment czasowy przejścia epistem czy dyskursów, ich wzajemne displacement jest niemal niemożliwe do precyzyjnego uchwycenia) złożony i bogaty dorobek badaczy oraz myślicieli tej rangi, co Adorno, Horkheimer, Benjamin, Fromm, Lowenthal i – oczywista – Marcuse, wydaje się czymś defi nitywnie domkniętym, ale bynajmniej nie martwym, o czym zaświadcza chociażby utrzymywana w tej aurze myślowej działalność Habermasa. Posługując się teoriomnogościowym terminem „domknięty”, wskazujemy na określoną możliwość dokonania wiążących ocen, ewaluacji zmierzających do uznania danego zjawiska za trwały, niekwestionowalny wkład w dziedzictwo zachodnioeuropejskiej tradycji filozoficzno- socjologicznej."(...

Kierkegaard a Szestowowska koncepcja zagrożeń autentyczności egzystencji

The paper presents relation and similarities between two existential authors: Kierkegaard and Shestov. The works of these two philosophers rises from the concern about the situation of a modern man. Kierkegaard in his famous conception of three types of existence gives a vivid picture of dangers which await for a human being. Shestov sees the danger for authenticity of the human being in higher and higher development of the idea of ratio in his days. The reason force human existence to be his only and one God. But for these two existential philosophers a man needs to be free – which means to be conscious and to choose with knowing consequences. Thus they call – paradoxically – sola fi de in order to oppose against those – in their opinion – demonical forces which make existence miserable

Kierkegaard and Shestov’s concept of jeopardised authenticity of the human being

The paper presents relation and similarities between two existential authors: Kierkegaard and Shestov. The works of these two philosophers rises from the concern about the situation of a modern man. Kierkegaard in his famous conception of three types of existence gives a vivid picture of dangers which await for a human being. Shestov sees the danger for authenticity of the human being in higher and higher development of the idea of ratio in his days. The reason force human existence to be his only and one God. But for these two existential philosophers a man needs to be free - which means to be conscious and to choose with knowing consequences. Thus they call - paradoxically - sola fi de in order to oppose against those - in their opinion - demonical forces which make existence miserable

Insufficiency of ventral hippocampus to medial prefrontal cortex transmission explains antidepressant non-response

Bibliogr. s. 1261-1264Background: There is extensive evidence that antidepressant drugs restore normal brain function by repairing damage to ventral hippocampus (vHPC) and medial prefrontal cortex (mPFC). While the damage is more extensive in hippocampus, the evidence of treatments, such as deep brain stimulation, suggests that functional changes in prefrontal cortex may be more critical. We hypothesized that antidepressant non-response may result from an insufficiency of transmission from vHPC to mPFC. Method: Antidepressant non-responsive Wistar Kyoto (WKY) rats were subjected to chronic mild stress (CMS), then treated with chronic daily administration of the antidepressant drug venlafaxine (VEN) and/or repeated weekly optogenetic stimulation (OGS) of afferents to mPFC originating from vHPC or dorsal HPC (dHPC). Results: As in many previous studies, CMS decreased sucrose intake, open-arm entries on the elevated plus maze (EPM), and novel object recognition (NOR). Neither VEN nor vHPC–mPFC OGS alone was effective in reversing the effects of CMS, but the combination of chronic VEN and repeated OGS restored normal behaviour on all three measures. dHPC–mPFC OGS restored normal behaviour in the EPM and NOR test irrespective of concomitant VEN treatment, and had no effect on sucrose intake. Conclusions: The synergism between VEN and vHPC–mPFC OGS supports the hypothesis that the antidepressant non-responsiveness of WKY rats results from a failure of antidepressant treatment fully to restore transmission in the vHPC–mPFC pathway

AMPA receptors mediate the pro-cognitive effects of electrical and optogenetic stimulation of the medial prefrontal cortex in antidepressant non-responsive Wistar-Kyoto rats

Background: The chronic mild stress (CMS) procedure is a widely used animal model of depression, and its application in Wistar–Kyoto (WKY) rats has been validated as a model of antidepressant-refractory depression. While not responding to chronic treatment with antidepressant drugs, WKY rats do respond to acute deep brain stimulation (DBS) of the medial prefrontal cortex (mPFC). In antidepressant-responsive strains there is evidence suggesting a role for AMPA subtype of glutamate receptor in the action mechanism of both antidepressants and DBS. Methods: Animals were subjected to CMS for 6 to 8weeks; sucrose intake was monitored weekly and novel object recognition (NOR) test was conducted following recovery from CMS. Wistars were treated chronically with venlafaxine (VEN), while WKY were treated acutely with either DBS, optogenetic stimulation (OGS) of virally-transduced (AAV5-hSyn-ChR2-EYFP) mPFC or ventral hippocampus, or acute intra-mPFC injection of the AMPA receptor positive allosteric modulator CX-516. The AMPA receptor antagonist NBQX was administered, at identical sites in mPFC, immediately following the exposure trial in the NOR. Results: Sucrose intake and NOR were suppressed by CMS, and restored by VEN in Wistars and by DBS, OGS, or CX-516 in WKY. However, OGS of the ventral hippocampal afferents to mPFC was ineffective. A low dose of NBQX selectively blocked the procognitive effect of VEN, DBS and OGS. Conclusions: These results suggest that activation of AMPA receptors in the mPFC represents a common pathway for the antidepressant effects of both conventional (VEN) and novel (DBS, OGS) antidepressant modalities, in both antidepressant responsive (Wistar) and antidepressant-resistant (WKY) rats

Ocena wybranych wskaźników stanu zdrowia populacji dziecięcej powiatu kutnowskiego pod kątem ryzyka rozwoju chorób układu sercowo-naczyniowego

Introduction. Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the adult population. The prevention of cardiovascular diseases depends to a great extent on eliminating risk factors already present in early childhood, thus avoiding secondary cardiovascular events. The aim of this study was to evaluate selected indicators of health status as risk factors for the development of CVD in a paediatric population from Kutno district as part of the project: ‘You live for yourself and others — take care of your health’. Material and methods. The study included 101 children aged from one to 11 years. All children underwent a physical examination. Based on a questionnaire conducted among the parents of the children, information was obtained regarding perinatal history, physical activity, time spent in front of a television, computer or tablet, eating habits, exposure to passive smoking and any family history of CVD. Laboratory tests were also performed, including a lipid profile. A 12-lead electrocardiogram and a screening echocardiographic examination were carried out. Results. On physical examination, 9.9% of the children were observed to be overweight and 12.87% to be obese. In 3.96% of this group of children, arterial hypertension was observed. In laboratory tests, significant abnormalities were observed in the lipid profiles. Of the children with an abnormal lipid profile, 11.5% were also found to be overweight or obese or with hypertension. The questionnaire revealed that the average daily time the children spent in physical activity was 4.15 hours. More than half of the children ate fast food occasionally or regularly. Exposure to passive smoking was revealed in 15.84% of the children, and a family history of CVD was identified in 17.82% of the children. Conclusions. The health of Kutno district children is similar to the health of children from other developed countries. Despite better physical activity and normal glucose values, other risk factors did not differ significantly from other paediatric populations.Wstęp. Choroby układu sercowo-naczyniowego (CVD) są główną przyczyną chorobowości i śmiertelności w populacjiosób dorosłych. Ich profilaktyka odgrywa ogromną rolę w wyeliminowaniu niekorzystnego wpływu czynników ryzyka jużw okresie wczesnego dzieciństwa, co pozwala uniknąć wystąpienia wtórnych zdarzeń sercowo-naczyniowych. Celempracy jest ocena wybranych wskaźników stanu zdrowia populacji dziecięcej powiatu kutnowskiego pod kątem ryzykarozwoju CVD w ramach projektu „Żyjesz dla siebie i innych — zadbaj o zdrowie”. Materiał i metody. Badaniem objęto grupę 101 dzieci w wieku 1–11 lat. U wszystkich przeprowadzono badanie przedmiotowe.Ponadto przeprowadzono badanie ankietowe dotyczące: wywiadu okołoporodowego, aktywności fizycznej,czasu spędzanego przed telewizorem, nawyków żywieniowych, narażenia na bierne palenie tytoniu oraz występowaniaCVD w rodzinie. Wykonywano także badania laboratoryjne, w tym lipidogram oraz zapis spoczynkowego 12-odprowadzeniowegoelektrokardiogramu (EKG) i przesiewowe badanie echokardiograficzne. Wyniki. W badaniu przedmiotowym u 9,9% dzieci stwierdzano nadwagę, a u 12,87% dzieci — otyłość. W tej grupie pacjentówu 3,96% dzieci stwierdzano nieprawidłowe wartości ciśnienia tętniczego. W wykonanych badaniach laboratoryjnychistotne odchylenia obserwowano w zakresie lipidogramu. W grupie dzieci z nieprawidłowościami lipidogramu 11,5%towarzyszyły nadwaga, otyłość i nadciśnienie tętnicze. Na podstawie przeprowadzonego badania ankietowego ustalono,że średni czas spędzany przez dziecko na aktywności fizycznej to 4,15 godziny. Więcej niż połowa dzieci spożywałaokazyjnie lub często pokarmy typu fast-food. Na bierne palenie tytoniu było narażonych 15,84% dzieci. Wywiad rodzinnyw kierunku CVD był pozytywny u 17,82% dzieci. W standardowym zapisie EKG oraz w badaniu echokardiograficznymu nie stwierdzano istotnych odchyleń od normy. Wnioski. Stan zdrowia dzieci powiatu kutnowskiego jest zbliżony do stanu zdrowia dzieci z innych krajów rozwiniętych.Mimo lepszych wyników w zakresie aktywności fizycznej oraz prawidłowych wartości glikemii, inne czynniki ryzyka nieodbiegały istotnie od wyników badań dotyczących innych populacji dziecięcych

Mesolimbic dopamine D_{2} receptor plasticity contributes to stress resilience in rats subjected to chronic mild stress

RATIONALE: Few studies have investigated neurobiological and biochemical differences between stress-resilient and stress-vulnerable experimental animals. OBJECTIVES: We investigated alterations in mesolimbic dopamine D(2) receptor density and mRNA expression level in stressed rats at two time points, i.e. after 2 and 5 weeks of chronic mild stress (CMS). METHODS: We used the chronic mild stress paradigm because it is a well-established animal model of depression. Two groups of stressed rats were distinguished during CMS experiments: (1) stress reactive (70 %), which displayed a decrease in the drinking of a palatable sucrose solution during the stress regimen, and (2) stress resilient (30 %), which exhibited an unaltered drinking profile when compared with the unchallenged control group. [(3)H]Domperidone was used as a ligand to label dopamine D(2) receptors, and a mixture of three specific oligonucleotides was used to evaluate dopamine D(2) receptor mRNA changes in various regions of the rat brain. RESULTS: CMS strongly affected the mesolimbic dopamine circuit in stress-resilient group after 2 weeks and stress-reactive group of rats after 5 weeks which exhibited a decrease in the level of dopamine D(2) receptor protein without alterations in D(2) mRNA expression. Stress-resilient animals, but not stress-reactive animals, effectively adapted to the extended stress and coped with it. The increase in D(2) mRNA expression returned the dopamine D(2) receptor density to control levels in stress-resilient rats after 5 weeks of CMS, but not in stress-reactive animals. CONCLUSIONS: These results clearly demonstrate that, despite earlier blunting, the activation of dopamine receptor biosynthesis in the dopamine mesoaccumbens system in stress-resilient rats is involved in active coping with stressful experiences, and it exhibits a delay in time

Placenta previa percreta with bladder involvement managed conservatively – case report

Placenta percreta is potentially a life-threatening condition. Pelvic organ invasion of the placenta carries high mortality and morbidity to the mother and fetus. We present a 33 year old gravida 3, para 2-0-0 female with placenta previa, percreta with bladder invasion. Placental invasion caused a giant vesicouterine fistula. The pregnant woman was managed conservatively until 33 weeks gestation, at which time she underwent a classical cesarean section. Postoperatively the patient was treated with methotrexate. Immediately postpartum the placenta was left in situ and successfully removed transvaginally after 11 weeks postpartum