Fracture mechanics description of the defect in rolling cylinder

project m- IPMinfra (CZ.02.1.01/0.0/0.0/16_013/0001823

Methods for identifying high-redshift galaxy cluster candidates

Recent theories linked long gamma ray bursts (GRBs) to galaxies with rapid star formation or starburst; thus, we expect that long GRBs (LGRBs) are more frequent in midcluster galaxies where mergers and tidal interactions between gas-rich galaxies are more likely to occur. Yet there is no galaxy cluster known to be associated with LGRBs. We demonstrate that, based on deep, single-band Subaru Hyper Suprime-Cam observations, we may provide constraints on photometric redshifts of groups of galaxies. We compare three methods: cosmological approach, pseudoinverse matrix, and random forests to estimate galaxy and quasar redshifts. Comparing our results to spectroscopic redshifts of Sloan Digital Sky Survey's-detected extragalactic sources, random forests may provide the highest accuracy with as low as 17 percentage error. This is a powerful method to find clusters to place GRB host galaxies in their local environment

ClC-1 mutations in myotonia congenita patients: insights into molecular gating mechanisms and genotype-phenotype correlation

Loss-of-function mutations of the skeletal muscle ClC-1 channel cause myotonia congenita with variable phenotypes. Using patch clamp we show that F484L, located in the conducting pore, probably induces mild dominant myotonia by right-shifting the slow gating of ClC-1 channel, without exerting a dominant-negative effect on the wild-type (WT) subunit. Molecular dynamics simulations suggest that F484L affects the slow gate by increasing the frequency and the stability of H-bond formation between E232 in helix F and Y578 in helix R. Three other myotonic ClC-1 mutations are shown to produce distinct effects on channel function: L198P shifts the slow gate to positive potentials, V640G reduces channel activity, while L628P displays a WT-like behaviour (electrophysiology data only). Our results provide novel insight into the molecular mechanisms underlying normal and altered ClC-1 function

Galactic foreground of gamma-ray bursts from AKARI Far-Infrared Surveyor

We demonstrate the use of the AKARI FIS All-Sky Survey maps in the study of extragalactic objects. A quick but reliable estimate of the Galactic foreground is essential for extragalactic research in general. We explored the galactic foreground and calculated hydrogen column densities using AKARI FIS and other recent all-sky survey data, and compared our results to former estimates. Our AKARI-FIS-based foreground values were then used toward gamma-ray burst (GRB) sources as input for X-ray afterglow spectrum fitting. From those fits the intrinsic column densities at the GRB sources were derived. The high-angular-resolution AKARI-FIS-based Galactic foreground hydrogen column densities are statistically very similar, but for most of the tested directions somewhat lower than previous estimates based on low-resolution data. This is due to the low filling factor of high-density enhancements in all galactic latitudes. Accordingly, our AKARI-FIS-based new intrinsic hydrogen column densities are usually higher or similar compared to the values calculated based, e.g., on the low-resolution Leiden/Argentine/Bonn survey data and listed in the Leicester database. The variation, however, is typically smaller than the error of the estimate from the fits of the X-ray afterglow spectra. There are a number of directions where the improvement of the foreground estimates resulted in an overestimate of magnitude or higher increment of the derived intrinsic hydrogen column densities. We concluded that most of the GRBs with formerly extremely low intrinsic hydrogen column densities are in fact normal, but we confirmed that GRB050233 is indeed a non- enveloped long GRB

A comparative analysis of European press coverage of children and the internet

This article reports a content analysis of press coverage of children and the internet in order to examine cross-cultural similarities and differences in the news values framing accounts of the benefits from and risks facing children online. By comparing media reporting in 14 European countries, the study found greater coverage of online risks than opportunities across Europe, which appears to be due to the high position of crime stories on the news agenda.. Thus readers, including parents, are exposed to media representations that often show the online world as being risky for children, which may affect perceptions of the prevalence of risk. However, there is national variation in terms of which risks receive more press attention, meaning that parents in different countries are potentially sensitised to different risks

Renormalization in Quantum Field Theory: An Improved Rigorous Method

The perturbative construction of the S-matrix in the causal spacetime approach of Epstein and Glaser may be interpreted as a method of regularization for divergent Feynman diagrams. The results of any method of regularization must be equivalent to those obtained from the Epstein-Glaser (EG) construction, within the freedom left by the latter. In particular, the conceptually well-defined approach of Bogoliubov, Parasuk, Hepp, and Zimmermann (BPHZ), though conceptually different from EG, meets this requirement. Based on this equivalence we propose a modified BPHZ procedure which provides a significant simplification of the techniques of perturbation theory, and which applies equally well to standard quantum field theory and to chiral theories. We illustrate the proposed method by a number of examples of various orders in perturbation theory. At the level of multi-loop diagrams we find that subdiagrams as classified by Zimmermann's forest formula in BPHZ may be restricted to subdiagrams in the sense of Epstein-Glaser, thus entailing an important reduction of actual computations. Furthermore, the relationship of our approach to the method of dimensional regularization is particularly transparent, without having to invoke analytic continuation to unphysical spacetime dimension, and sheds new light on certain parameters within dimensional regularization.Comment: 19 pages, 3 figure

Dynamic Analysis of Vascular Morphogenesis Using Transgenic Quail Embryos

Background: One of the least understood and most central questions confronting biologists is how initially simple clusters or sheet-like cell collectives can assemble into highly complex three-dimensional functional tissues and organs. Due to the limits of oxygen diffusion, blood vessels are an essential and ubiquitous presence in all amniote tissues and organs. Vasculogenesis, the de novo self-assembly of endothelial cell (EC) precursors into endothelial tubes, is the first step in blood vessel formation [1]. Static imaging and in vitro models are wholly inadequate to capture many aspects of vascular pattern formation in vivo, because vasculogenesis involves dynamic changes of the endothelial cells and of the forming blood vessels, in an embryo that is changing size and shape. Methodology/Principal Findings: We have generated Tie1 transgenic quail lines Tg(tie1:H2B-eYFP) that express H2B-eYFP in all of their endothelial cells which permit investigations into early embryonic vascular morphogenesis with unprecedented clarity and insight. By combining the power of molecular genetics with the elegance of dynamic imaging, we follow the precise patterning of endothelial cells in space and time. We show that during vasculogenesis within the vascular plexus, ECs move independently to form the rudiments of blood vessels, all while collectively moving with gastrulating tissues that flow toward the embryo midline. The aortae are a composite of somatic derived ECs forming its dorsal regions and the splanchnic derived ECs forming its ventral region. The ECs in the dorsal regions of the forming aortae exhibit variable mediolateral motions as they move rostrally; those in more ventral regions show significant lateral-to-medial movement as they course rostrally. Conclusions/Significance: The present results offer a powerful approach to the major challenge of studying the relative role(s) of the mechanical, molecular, and cellular mechanisms of vascular development. In past studies, the advantages of the molecular genetic tools available in mouse were counterbalanced by the limited experimental accessibility needed for imaging and perturbation studies. Avian embryos provide the needed accessibility, but few genetic resources. The creation of transgenic quail with labeled endothelia builds upon the important roles that avian embryos have played in previous studies of vascular development