Partial tests, universal tests and decomposability

For a property P and a sub-property P', we say that P is P'-partially testable with q queries} if there exists an algorithm that distinguishes, with high probability, inputs in P' from inputs ε-far from P, using q queries. Some natural properties require many queries to test, but can be partitioned into a small number of subsets for which they are partially testable with very few queries, sometimes even a number independent of the input size. For properties over {0,1}, the notion of being thus partitionable ties in closely with Merlin-Arthur proofs of Proximity (MAPs) as defined independently in [14] a partition into r partially-testable properties is the same as a Merlin-Arthur system where the proof consists of the identity of one of the r partially-testable properties, giving a 2-way translation to an O(log r) size proof. Our main result is that for some low complexity properties a partition as above cannot exist, and moreover that for each of our properties there does not exist even a single sub-property featuring both a large size and a query-efficient partial test, in particular improving the lower bound set in [14]. For this we use neither the traditional Yao-type arguments nor the more recent communication complexity method, but open up a new approach for proving lower bounds. First, we use entropy analysis, which allows us to apply our arguments directly to 2-sided tests, thus avoiding the cost of the conversion in [14] from 2-sided to 1-sided tests. Broadly speaking we use "distinguishing instances" of a supposed test to show that a uniformly random choice of a member of the sub-property has "low entropy areas", ultimately leading to it having a low total entropy and hence having a small base set. Additionally, to have our arguments apply to adaptive tests, we use a mechanism of "rearranging" the input bits (through a decision tree that adaptively reads the entire input) to expose the low entropy that would otherwise not be apparent. We also explore the possibility of a connection in the other direction, namely whether the existence of a good partition (or MAP) can lead to a relatively query-efficient standard property test. We provide some preliminary results concerning this question, including a simple lower bound on the possible trade-off. Our second major result is a positive trade-off result for the restricted framework of 1-sided proximity oblivious tests. This is achieved through the construction of a "universal tester" that works the same for all properties admitting the restricted test. Our tester is very related to the notion of sample-based testing (for a non-constant number of queries) as defined by Goldreich and Ron in [13]. In particular it partially resolves an open problem raised by [13]

Information capacity of optical fiber channels with zero average dispersion

We study the statistics of optical data transmission in a noisy nonlinear fiber channel with a weak dispersion management and zero average dispersion. Applying path integral methods we have found exactly the probability density functions of channel output both for a non-linear noisy channel and for a linear channel with additive and multiplicative noise. We have obtained analytically a lower bound estimate for the Shannon capacity of considered nonlinear fiber channel.Comment: 4 pages, subbmited to Phys. Rev. Let

Spatiotemporal Response of Crystals in X-ray Bragg Diffraction

The spatiotemporal response of crystals in x-ray Bragg diffraction resulting from excitation by an ultra-short, laterally confined x-ray pulse is studied theoretically. The theory presents an extension of the analysis in symmetric reflection geometry [1] to the generic case, which includes Bragg diffraction both in reflection (Bragg) and transmission (Laue) asymmetric scattering geometries. The spatiotemporal response is presented as a product of a crystal-intrinsic plane wave spatiotemporal response function and an envelope function defined by the crystal-independent transverse profile of the incident beam and the scattering geometry. The diffracted wavefields exhibit amplitude modulation perpendicular to the propagation direction due to both angular dispersion and the dispersion due to Bragg's law. The characteristic measure of the spatiotemporal response is expressed in terms of a few parameters: the extinction length, crystal thickness, Bragg angle, asymmetry angle, and the speed of light. Applications to self-seeding of hard x-ray free electron lasers are discussed, with particular emphasis on the relative advantages of using either the Bragg or Laue scattering geometries. Intensity front inclination in asymmetric diffraction can be used to make snapshots of ultra-fast processes with femtosecond resolution

Consciousness, Functional Networks and Delirium Screening.

BACKGROUND: Consciousness, the medium of sentient thought, requires integrity of functional networks and their connectivity. In health, they function as a co-operative but mutually exclusive paradigm of introspection versus external awareness subserved via the Default Mode Network and Task Positive State, respectively. Higher thinking in the conscious state is then segregated according to need. There is research evidence to suggest that functional networks may be impacted in disorders of consciousness and conceptual support for a mechanistic role in delirium. This potentially central aspect of delirium manifestation is relatively unexplored. OBJECTIVE: This article describes the role of disrupted functional networks in delirium. How this relates to current understanding of delirium neurobiology and the ramifications for clinical diagnosis is discussed. METHOD: A review of the role of functional networks, particularly DMN and TPN, has been undertaken with respect to health and delirium. An exploration of how symptoms of delirium may be related to functional network aberrancy has been undertaken. Implications for research and clinical practice in delirium have been presented. RESULTS: In delirium, a disturbance of consciousness, the DMN is pathologically co-activated and functional cortical connectivity is compromised. The clinical correlate is of an experiential singularity where internal and external drivers become indistinguishable, reality and delusion merge and the notion of self is effaced. Our group propose that functional network disruption in conjunction with cortical disconnectivity is central to the mechanism of delirium. Clinical tools may exploit the neurobiology of delirium to improve its diagnosis and an example of such a simple screening instrument (SQeeC) is provided. CONCLUSION: Functional networks are critically disrupted in delirium and may be central to clinical features. A better understanding of the neurobiology of delirium will generate research opportunities with potential for therapeutic gains in detection, diagnosis, and management

Random Unitaries Give Quantum Expanders

We show that randomly choosing the matrices in a completely positive map from the unitary group gives a quantum expander. We consider Hermitian and non-Hermitian cases, and we provide asymptotically tight bounds in the Hermitian case on the typical value of the second largest eigenvalue. The key idea is the use of Schwinger-Dyson equations from lattice gauge theory to efficiently compute averages over the unitary group.Comment: 14 pages, 1 figur

Time dependence of Bragg forward scattering and self-seeding of hard x-ray free-electron lasers

Free-electron lasers (FELs) can now generate temporally short, high power x-ray pulses of unprecedented brightness, even though their longitudinal coherence is relatively poor. The longitudinal coherence can be potentially improved by employing narrow bandwidth x-ray crystal optics, in which case one must also understand how the crystal affects the field profile in time and space. We frame the dynamical theory of x-ray diffraction as a set of coupled waves in order to derive analytic expressions for the spatiotemporal response of Bragg scattering from temporally short incident pulses. We compute the profiles of both the reflected and forward scattered x-ray pulses, showing that the time delay of the wave $\tau$ is linked to its transverse spatial shift $\Delta x$ through the simple relationship $\Delta x = c\tau \cot\theta$, where $\theta$ is the grazing angle of incidence to the diffracting planes. Finally, we apply our findings to obtain an analytic description of Bragg forward scattering relevant to monochromatically seed hard x-ray FELs.Comment: 11 pages, 6 figure

Survivin a radiogenetic promoter for glioblastoma viral gene therapy independently from CArG motifs

BACKGROUND: Radiogenetic therapy is a novel approach in the treatment of cancer, which employs genetic modification to alter the sensitivity of tumor cells to the effect of applied radiation. AIM: To select a potent radiation inducible promoter in the context of brain tumors and to investigate if CArG radio responsive motifs or other elements in the promoter nucleotide sequences can correlate to its response to radiation. METHODS: To select initial candidates for promoter inducible elements, the levels of mRNA expression of six different promoters were assessed using Quantitative RTPCR in D54 MG cells before and after radiation exposure. Recombinant Ad/reporter genes driven by five different promoters; CMV, VEGF, FLT-1, DR5 and survivin were constructed. Glioma cell lines were infected with different multiplicity of infection of the (promoter) Ad or CMV Ad. Cells were then exposed to a range of radiation (0–12 Gy) at single fraction. Fluorescent microscopy, Luc assay and X-gal staining was used to detect the level of expression of related genes. Different glioma cell lines and normal astrocytes were infected with Ad survivin and exposed to radiation. The promoters were analyzed for presence of CArG radio-responsive motifs and CCAAT box consensus using NCBI blast bioinformatics software. RESULTS: Radiotherapy increases the expression of gene expression by 1.25–2.5 fold in different promoters other than survivin after 2 h of radiation. RNA analysis was done and has shown an increase in copy number of tenfold for survivin. Most importantly cells treated with RT and Ad Luc driven by survivin promoter showed a fivefold increase in expression after 2 Gy of radiation in comparison to non-irradiated cells. Presence or absence of CArG motifs did not correlate with promoter response to radiation. Survivin with the best response to radiation had the lowest number of CCAAT box. CONCLUSION: Survivin is a selective potent radiation inducible promoter for glioblastoma viral gene therapy and this response to radiation could be independent of CArG motifs

Ultimate Precision of Adaptive Noise Estimation

We consider the estimation of noise parameters in a quantum channel, assuming the most general strategy allowed by quantum mechanics. This is based on the exploitation of unlimited entanglement and arbitrary quantum operations, so that the channel inputs may be interactively updated. In this general scenario, we draw a novel connection between quantum metrology and teleportation. In fact, for any teleportation-covariant channel (e.g., Pauli, erasure, or Gaussian channel), we find that adaptive noise estimation cannot beat the standard quantum limit, with the quantum Fisher information being determined by the channel’s Choi matrix. As an example, we establish the ultimate precision for estimating excess noise in a thermal-loss channel, which is crucial for quantum cryptography. Because our general methodology applies to any functional that is monotonic under trace-preserving maps, it can be applied to simplify other adaptive protocols, including those for quantum channel discrimination. Setting the ultimate limits for noise estimation and discrimination paves the way for exploring the boundaries of quantum sensing, imaging, and tomography

A stochastic network with mobile users in heavy traffic

We consider a stochastic network with mobile users in a heavy-traffic regime. We derive the scaling limit of the multi-dimensional queue length process and prove a form of spatial state space collapse. The proof exploits a recent result by Lambert and Simatos which provides a general principle to establish scaling limits of regenerative processes based on the convergence of their excursions. We also prove weak convergence of the sequences of stationary joint queue length distributions and stationary sojourn times.Comment: Final version accepted for publication in Queueing Systems, Theory and Application