64 research outputs found
Single photon absorption by a single quantum emitter
We show that a three-level lambda quantum emitter with equal spontaneous
emission rates on both optically active transitions can absorb an incident
light field with a probability approaching unity, provided that the focused
light profile matches that of the emitter dipole emission pattern. Even with
realistic focusing geometries, our results could find applications in
long-distance entanglement of spin qubits.Comment: 4 pages, 4 figure
A computational study on how structure influences the optical properties in model crystal structures of amyloid fibrils
Amyloid fibrils have been shown to have peculiar optical properties since they can exhibit fluorescence in the absence of aromatic residues. In a recent study, we have shown that proton transfer (PT) events along hydrogen bonds (HBs) are coupled to absorption in the near UV range. Here, we gain more insights into the different types of hydrogen bonding interactions that occur in our model systems and the molecular factors that control the susceptibility of the protons to undergo PT and how this couples to the optical properties. In the case of the strong N–C termini interactions, a nearby methionine residue stabilizes the non-zwitterionic NH–COOH pair, while zwitterionic NH+–COO– is stabilized by the proximity of nearby crystallographic water molecules. Proton motion along the hydrogen bonds in the fibril is intimately coupled to the compression of the heavier atoms, similar to what is observed in bulk water. Small changes in the compression of the hydrogen bonds in the protein can lead to significant changes in both the ground and excited state potential energy surfaces associated with PT. Finally, we also reinforce the importance of nuclear quantum fluctuations of protons in the HBs of the amyloid proteins
α-Synuclein fibril and synaptic vesicle interactions lead to vesicle destruction and increased lipid-associated fibril uptake into iPSC-derived neurons
Monomeric alpha-synuclein (aSyn) is a well characterised protein that importantly binds to lipids. aSyn monomers assemble into amyloid fibrils which are localised to lipids and organelles in insoluble structures found in Parkinson’s disease patient’s brains. Previous work to address pathological aSyn-lipid interactions has focused on using synthetic lipid membranes, which lack the complexity of physiological lipid membranes. Here, we use physiological membranes in the form of synaptic vesicles (SV) isolated from rodent brain to demonstrate that lipid-associated aSyn fibrils are more easily taken up into iPSC-derived cortical i3Neurons. Lipid-associated aSyn fibril characterisation reveals that SV lipids are an integrated part of the fibrils and while their fibril morphology differs from aSyn fibrils alone, the core fibril structure remains the same, suggesting the lipids lead to the increase in fibril uptake. Furthermore, SV enhance the aggregation rate of aSyn, yet increasing the SV:aSyn ratio causes a reduction in aggregation propensity. We finally show that aSyn fibrils disintegrate SV, whereas aSyn monomers cause clustering of SV using small angle neutron scattering and high-resolution imaging. Disease burden on neurons may be impacted by an increased uptake of lipid-associated aSyn which could enhance stress and pathology, which in turn may have fatal consequences for neurons
Spin-photon interface and spin-controlled photon switching in a nanobeam waveguide
Access to the electron spin is at the heart of many protocols for integrated
and distributed quantum-information processing [1-4]. For instance, interfacing
the spin-state of an electron and a photon can be utilized to perform quantum
gates between photons [2,5] or to entangle remote spin states [6-9].
Ultimately, a quantum network of entangled spins constitutes a new paradigm in
quantum optics [1]. Towards this goal, an integrated spin-photon interface
would be a major leap forward. Here we demonstrate an efficient and optically
programmable interface between the spin of an electron in a quantum dot and
photons in a nanophotonic waveguide. The spin can be deterministically prepared
with a fidelity of 96\%. Subsequently the system is used to implement a
"single-spin photonic switch", where the spin state of the electron directs the
flow of photons through the waveguide. The spin-photon interface may enable
on-chip photon-photon gates [2], single-photon transistors [10], and efficient
photonic cluster state generation [11]
Narrowband Biphotons: Generation, Manipulation, and Applications
In this chapter, we review recent advances in generating narrowband biphotons
with long coherence time using spontaneous parametric interaction in monolithic
cavity with cluster effect as well as in cold atoms with electromagnetically
induced transparency. Engineering and manipulating the temporal waveforms of
these long biphotons provide efficient means for controlling light-matter
quantum interaction at the single-photon level. We also review recent
experiments using temporally long biphotons and single photons.Comment: to appear as a book chapter in a compilation "Engineering the
Atom-Photon Interaction" published by Springer in 2015, edited by A.
Predojevic and M. W. Mitchel
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction.
Alpha-synuclein is known to bind to small unilamellar vesicles (SUVs) via its N terminus, which forms an amphipathic alpha-helix upon membrane interaction. Here we show that calcium binds to the C terminus of alpha-synuclein, therewith increasing its lipid-binding capacity. Using CEST-NMR, we reveal that alpha-synuclein interacts with isolated synaptic vesicles with two regions, the N terminus, already known from studies on SUVs, and additionally via its C terminus, which is regulated by the binding of calcium. Indeed, dSTORM on synaptosomes shows that calcium mediates the localization of alpha-synuclein at the pre-synaptic terminal, and an imbalance in calcium or alpha-synuclein can cause synaptic vesicle clustering, as seen ex vivo and in vitro. This study provides a new view on the binding of alpha-synuclein to synaptic vesicles, which might also affect our understanding of synucleinopathies
Generation of a wave packet tailored to efficient free space excitation of a single atom
We demonstrate the generation of an optical dipole wave suitable for the
process of efficiently coupling single quanta of light and matter in free
space. We employ a parabolic mirror for the conversion of a transverse beam
mode to a focused dipole wave and show the required spatial and temporal
shaping of the mode incident onto the mirror. The results include a proof of
principle correction of the parabolic mirror's aberrations. For the application
of exciting an atom with a single photon pulse we demonstrate the creation of a
suitable temporal pulse envelope. We infer coupling strengths of 89% and
success probabilities of up to 87% for the application of exciting a single
atom for the current experimental parameters.Comment: to be published in Europ. Phys. J.
Ultrafast all-optical switching by single photons
An outstanding goal in quantum optics is the realization of fast optical
non-linearities at the single-photon level. Such non-linearities would allow
for the realization of optical devices with new functionalities such as a
single-photon switch/transistor or a controlled-phase gate, which could form
the basis of future quantum optical technologies. While non-linear optics
effects at the single-emitter level have been demonstrated in different
systems, including atoms coupled to Fabry-Perot or toroidal micro-cavities,
super-conducting qubits in strip-line resonators or quantum dots (QDs) in
nano-cavities, none of these experiments so far has demonstrated single-photon
switching on ultrafast timescales. Here, we demonstrate that in a strongly
coupled QD-cavity system the presence of a single photon on one of the
fundamental polariton transitions can turn on light scattering on a transition
from the first to the second Jaynes-Cummings manifold with a switching time of
20 ps. As an additional device application, we use this non-linearity to
implement a single-photon pulse-correlator. Our QD-cavity system could form the
building-block of future high-bandwidth photonic networks operating in the
quantum regime
Ion traps with enhanced optical and physical access
Small, controllable, highly accessible quantum systems can serve as probes at
the single quantum level to study multiple physical effects, for example in
quantum optics or for electric and magnetic field sensing. The applicability of
trapped atomic ions as probes is highly dependent on the measurement situation
at hand and thus calls for specialized traps. Previous approaches for ion traps
with enhanced optical access included traps consisting of a single ring
electrode or two opposing endcap electrodes. Other possibilities are planar
trap geometries, which have been investigated for Penning traps and rf-trap
arrays. By not having the electrodes lie in a common plane the optical access
in the latter cases can be substantially increased. Here, we discuss the
fabrication and experimental characterization of a novel radio-frequency (rf)
ion trap geometry. It has a relatively simple structure and provides largely
unrestricted optical and physical access to the ion, of up to 96% of the total
4pi solid angle in one of the three traps tested. We also discuss potential
applications in quantum optics and field sensing. As a force sensor, we
estimate sensitivity to forces smaller than 1 yN Hz^(-1/2).Comment: 6 pages, 3 figures. Corrections of some typos, application section
expanded to account for reviewer comment
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