Romanesque and territory. The construction materials of Sardinian medieval churches: new approaches to the valorization, conservation and restoration

This paper is intended to illustrate a multidisciplinary research project devoted to the study of the constructive materials of the Romanesque churches in Sardinia during the “Giudicati” period (11th -13th centuries). The project focuses on the relationship between a selection of monuments and their territory, both from a historical-architectural perspective and from a more modern perspective addressing future restoration works. The methodologies of the traditional art-historical research (study of bibliographic, epigraphic and archival sources, formal reading of artifacts) are flanked by new technologies: digital surveys executed with a 3D laser-scanner, analyses of the materials (stones, mortars, bricks) with different instrumental methods: X-ray fluorescence (XRF) and inductively coupled mass spectrometry (ICP-MS) for chemical composition, X-ray diffractometer (XRD) to determine the alteration phases (e.g., soluble salts), optical microscopy and electronic (SEM) to study textures, mineral assemblages and microstructures, termogravimetric/differential scanning, calorimetric analysis (TG/DTA) for the composition of the binder mortars. This multidisciplinary approach allows the achieving of important results in an archaeometric context: 1) from a historical point of view, with the possible identification of ancient traffics, trade routes, sources of raw materials, construction phases, wall textures; 2) from a conservative point of view, by studying chemical and physical weathering processes of stone materials compatible for replacement in case of future restoration works. Sardinian Romanesque architectural heritage is particularly remarkable: about 200 churches of different types and sizes, with the almost exclusive use of cut stones. Bi- or poly-chromy, deriving from the use of different building materials, characterizes many of these monuments, becoming also a vehicle for political and cultural meanings. The paper will present some case studies aimed to illustrate the progress of the project and the results achieved

Phase shifts of synchronized oscillators and the systolic/diastolic blood pressure relation

We study the phase-synchronization properties of systolic and diastolic arterial pressure in healthy subjects. We find that delays in the oscillatory components of the time series depend on the frequency bands that are considered, in particular we find a change of sign in the phase shift going from the Very Low Frequency band to the High Frequency band. This behavior should reflect a collective behavior of a system of nonlinear interacting elementary oscillators. We prove that some models describing such systems, e.g. the Winfree and the Kuramoto models offer a clue to this phenomenon. For these theoretical models there is a linear relationship between phase shifts and the difference of natural frequencies of oscillators and a change of sign in the phase shift naturally emerges.Comment: 8 figures, 9 page

An overview of coumarin as a versatile and readily accessible scaffold with broad-ranging biological activities

Privileged structures have been widely used as an effective template for the research and discovery of high value chemicals. Coumarin is a simple scaffold widespread in Nature and it can be found in a considerable number of plants as well as in some fungi and bacteria. In the last years, these natural compounds have been gaining an increasing attention from the scientific community for their wide range of biological activities, mainly due to their ability to interact with diverse enzymes and receptors in living organisms. In addition, coumarin nucleus has proved to be easily synthetized and decorated, giving the possibility of designing new coumarin-based compounds and investigating their potential in the treatment of various diseases. The versatility of coumarin scaffold finds applications not only in medicinal chemistry but also in the agrochemical field as well as in the cosmetic and fragrances industry. This review is intended to be a critical overview on coumarins, comprehensive of natural sources, metabolites, biological evaluations and synthetic approaches

Expanded Endoscopic Approach for Anterior Skull Base Tumors: Experience of a Multidisciplinary Skull Base Team

Abstract: The aim of this study is to describe the experience of a multidisciplinary skull base team with transnasal endoscopic surgery for anterior cranial base tumors. A retrospective chart review was conducted on patients who underwent an exclusive expanded transnasal approach to the anterior skull base in the period from December 2014 to November 2015. Data on patient demographics, tumor characteristics, surgical information, imaging, and postoperative complications were collected and analyzed. From a total of 120 patients with skull base diseases managed by the skull base team, 36 were admitted to this study. The overall complication rate in this series was 16.7%, gross total resection was achieved in 32 cases (88.9%) and postoperative CSF leakage occurred in 5 cases (13.9%). Our preliminary results confirm that an exclusive endoscopic transnasal approach to the anterior cranial base