A case of acute appendicitis with Vibrio fluvialis peritonitis

AbstractHuman infections caused by Vibrio fluvialis are rarely reported. The most common clinical presentation of V. fluvialis infection is acute gastroenteritis with diarrhea. Reported extra-intestinal infections caused by V. fluvialis have included bacteremia, hemorrhagic cellulitis and cerebritis. Peritonitis is an uncommon clinical presentation of Vibrio infections, and most cases have occurred in patients receiving peritoneal dialysis or those with liver cirrhosis. Herein, we report the first case of acute appendicitis with V. fluvialis peritonitis

Different Influences on Tacrolimus Pharmacokinetics by Coadministrations of Zhi Ke and Zhi Shi in Rats

Tacrolimus, an immunosuppressant with narrow therapeutic window, has been used widely in transplant patients. Grapefruit juice and pomelo have been reported to increase the blood levels of tacrolimus. Zhi Ke and Zhi Shi, the ripe peels and unripe fruits of Citrus aurantium which is chemotaxonomically related to grapefruit and pomelo, are in wide use in clinical Chinese medicine. To investigate the possible interaction of these two Citrus herbs with tacrolimus, male Sprague-Dawley rats were orally given tacrolimus (1.5 mg/kg) with and without Zhi Ke and Zhi Shi decoctions in a cross-over design. Blood samples were withdrawn via cardiopuncture at specific time and quantitated by a microparticle enzyme immunoassay. In addition, to explore the mechanism of interaction, LS 180 cell line was used for the transport study of rhodamine 123, a typical substrate of P-glycoprotein (P-gp). The results showed that Zhi Shi significantly decreased the Cmax and AUC0−t of tacrolimus by 72.4% and 72.0%, respectively, whereas Zhi Ke did not affect tacrolimus pharmacokinetics. LS 180 cell line study indicated that Zhi Shi increased the efflux activity of P-gp, enabling us to explain the decreased oral bioavailability of tacrolimus caused by Zhi Shi. Hence, we suggest that Zhi Shi be contraindicated for transplant patients treated with tacrolimus to reduce the risk of allograft rejection

Famílias em situação de rua: perspectivas de trabalhadores e usuários do suas sobre proteção social e guarda familiar

Apresentam-se resultados de pesquisa realizada entre 2012-2014 em Santos, litoral de São Paulo, que buscou identificar perspectivas sobre a guarda familiar de pessoas em situação de rua, a partir de entrevistas semiabertas com dez trabalhadores e uma família. A proteção social a famílias envolve complexas tomadas de decisões, cabendo destacar as particularidades da guarda familiar de pessoas em situação de rua tendo por base as mais diferentes perspectivas: políticas públicas, modos de efetivação dessas políticas pelos trabalhadores e singularidades de crianças e famílias. Identificou-se a intenção da família de manter a guarda dos filhos e o esboço de projetos de futuro que demandam serviços de proteção social. Entre trabalhadores, verifica-se inclinação à generalização, institucionalização e culpabilização das famílias, somada ao sentimento de impotência dos trabalhadores diante da complexidade da situação de rua. Discute-se a relevância de produzir espaços em que ambos os grupos possam participar da proposição de caminhos a serem trilhados

From insulator to quantum Hall liquid at low magnetic fields

We have performed low-temperature transport measurements on a GaAs two-dimensional electron system at low magnetic fields. Multiple temperature-independent points and accompanying oscillations are observed in the longitudinal resistivity between the low-field insulator and the quantum Hall (QH) liquid. Our results support the existence of an intermediate regime, where the amplitudes of magneto-oscillations can be well described by conventional Shubnikov-de Haas theory, between the low-field insulator and QH liquid.Comment: Magneto-oscillations governed by Shubnikov-de Haas theory are observed between the low-field insulator and quantum Hall liqui

Living near the port area is associated with physical inactivity and sedentary behavior

CONTEXT AND OBJECTIVE: The impact of the port of Santos, Brazil, on the population's health is unknown. We aimed to evaluate the association between living near the port area and physical inactivity and sedentary behavior. DESIGN AND SETTING: Cross-sectional study developed at a university laboratory and a diagnostic clinic. METHODS: 553 healthy adults were selected and their level of physical activity in daily life was assessed using accelerometers. Multiple linear and logistic regressions were performed using physical inactivity and sedentary behavior as the outcomes and living near the port area as the main risk factor, with adjustments for the main confounders. RESULTS: Among all the participants, 15% were resident near the port area. They took 699 steps/day and presented, weekly, 2.4% more sedentary physical activity, 2.0% less time in standing position and 0.9% more time lying down than residents of other regions. Additionally, living near the port area increased the risk of physical inactivity by 2.50 times and the risk of higher amounts of sedentary behavior (>= 10 hours/day) by 1.32 times. CONCLUSION: Living near the port of Santos is associated with physical inactivity and higher sedentary behavior among adults, regardless of confounders. The reasons for this association should be investigated in longitudinal studies.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Fed Sao Paulo, Lab Epidemiol & Human Movement Epidemiol & Movime, Santos, SP, BrazilUniv Fed Sao Paulo Unifesp, Dept Human Movement Sci, Ave Ana Costa 95, BR-11060001 Santos, SP, BrazilAngiocorpore Inst Cardiovasc Med, Dept Cardiovasc Med, Santos, SP, BrazilInst Coracao InCor, Sao Paulo, SP, BrazilHarvard TH Chan Sch Publ Hlth, Cardiovasc Hlth Program, Boston, MA USADepartment of Human Movement Sciences, Universidade Federal de São Paulo (Unifesp), Santos (SP), BrazilDepartment of Human Movement Sciences, Universidade Federal de São Paulo (Unifesp), Ave Ana Costa 95, BR-11060001, Santos (SP), BrazilFAPESP: 2011/07282-6Web of Scienc

Shortâ term and longâ term impacts of Helicobacter pylori eradication with reverse hybrid therapy on the gut microbiota

Background and AimsAntiâ Helicobacter pylori therapy may lead to the growth of pathogenic or antibioticâ resistant bacteria in the gut. The study aimed to investigate the shortâ term and longâ term impacts of H. pylori eradication with reverse hybrid therapy on the components and macrolide resistance of the gut microbiota.MethodsHelicobacter pyloriâ related gastritis patients were administered a 14â day reverse hybrid therapy. Fecal samples were collected before treatment and at the end of week 2, week 8, and week 48. The V3â V4 region of the bacterial 16S rRNA gene in fecal specimens was amplified by polymerase chain reaction and sequenced on Illumina MiSeq platform. Additionally, amplification of erm(B) gene (encoding erythromycin resistance methylase) was performed.ResultsReverse hybrid therapy resulted in decreased relative abundances of Firmicutes (from 62.0% to 30.7%; P < 0.001) and Actinobacteria (from 3.4% to 0.6%; 0.032) at the end of therapy. In contrast, the relative abundance of Proteobacteria increased from 10.2% to 49.1% (0.002). These microbiota alterations did not persist but returned to the initial levels at week 8 and week 48. The amount of erm(B) gene in fecal specimens was comparable with the pretreatment level at week 2 but increased at week 8 (0.025) and then returned to the pretreatment level by week 48.ConclusionsHelicobacter pylori eradication with reverse hybrid therapy can lead to shortâ term gut dysbiosis. The amount of erm(B) gene in the stool increased transiently after treatment and returned to the pretreatment level at 1â year postâ treatment.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/152555/1/jgh14736_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/152555/2/jgh14736.pd

Nondestructive quantitative analysis of water potential of tomato leaves using online hyperspectral imaging system

Tomatoes have different water requirements in each growing period. Excessive water use or insufficient water supply will affect the growth and yield of tomato plants. Therefore, precise irrigation control is necessary during cultivation to increase crop productivity. Traditionally, the soil moisture content or leaf water potential has been used as an indicator of plant water status. These methods, however, have limited accuracy and are time-consuming, making it difficult to be put into practice in tomato production. This study developed an online hyperspectral imaging system to measure the leaf water potential of tomato nondestructively. Linear Discriminant Analysis was utilized to automatically and quickly extract the leaf images, with the recognition accuracy of 94.68% was achieved. The mathematical processing of Standard Normal Variate scattering correction was used to remove the spectral variations caused by the defocused leave images. The developed leaf water potential prediction model based on the spectral image information attained using the developed system achieved the standard error of calibration of 0.201, coefficient of determination in calibration set of 0.814 and standard error of cross�validation of 0.230, and one minus the variance ratio of 0.755. The obtained performance indicated the feasibility of apply�ing the developed online hyperspectral imaging system as a real-time non-destructive measurement technique for the leaf water potential of tomato plants